Results 61 to 70 of about 8,423,709 (341)

Dose-Response Relationship of Neuromuscular Training for Injury Prevention in Youth Athletes: A Meta-Analysis

Frontiers in Physiology, 2017
Background: Youth athletes with intensive sports participation are at an increased risk of sustaining injuries. Neuromuscular training programs reduce sports-related injury risk in this population, however, the dose-response relationship is largely ...
S. Steib, A. Rahlf, K. Pfeifer, A. Zech
semanticscholar   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

The relationship between the treatment frequency and efficacy of acupuncture: A scoping review of clinical trials

Complementary Therapies in Medicine
Objective: To consolidate and analyze the existing evidence on the relationship between acupuncture treatment frequency and its clinical efficacy, clarify research status, trends, and core issues, and provide evidence-based insights for optimizing ...
Guodong Li, Xinyu Hu, Jingli Xing, Yiying Wang, Chenlu Wang, Wennan Yu, Jie Lian, Huijuan Cao   +7 more
doaj   +1 more source

Systematic evaluation of pembrolizumab dosing in patients with advanced non-small cell lung cancer [PDF]

, 2016
International audienceBACKGROUND: In the phase I KEYNOTE-001 study, pembrolizumab demonstrated durable antitumor activity in patients with advanced non-small cell lung cancer (NSCLC). We sought to characterize the relationship between pembrolizumab dose,
Ahamadi, M., Arkenau, H.-T., Cappuzzo, F., Chatterjee, M., De Alwis, D. P., Dong, D., Felip, E., Fløtten, Ø, Freshwater, T., Garon, E. B., Gubens, M. A., Hellmann, M. D., Horn, L., Hui, R., Im, E., Kondic, A. G., Lena, H., Li, C., Lubiniecki, G. M., Mayawala, K., Stone, J., Turner, D. C., Zhang, J.   +22 more
core   +2 more sources

Tooth Loss Is Associated With Increased Risk of Dementia and With a Dose-Response Relationship

Frontiers in Aging Neuroscience, 2018
Objective: Both tooth loss and dementia are age-related and frequently-occurring diseases. Increasing attention has been given to explore the pathogenesis related to oral-brain function disorders.
Jun Chen, Chang-Ju Ren, Lan Wu, Ling-yun Xia, Jun Shao, Wei-dong Leng, Xian-Tao Zeng   +6 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Association between dietary magnesium intake and risk of hypertension in Chinese adults

环境与职业医学, 2022
BackgroundMagnesium plays an important physiological role in human, but the association between dietary magnesium intake and the risk of hypertension is unclear. Few studies have reported the dose-response relationship in Chinese population.
Liusen WANG, Huijun WANG, Zhihong WANG, Hongru JIANG, Weiyi LI, Shaoshunzi WANG, Lixin HAO, Bing ZHANG, Gangqiang DING   +8 more
doaj   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Estimating the impact of city-wide Aedes aegypti population control: An observational study in Iquitos, Peru. [PDF]

, 2019
During the last 50 years, the geographic range of the mosquito Aedes aegypti has increased dramatically, in parallel with a sharp increase in the disease burden from the viruses it transmits, including Zika, chikungunya, and dengue.
Astete, Helvio, Halsey, Eric S, Kitron, Uriel, Kochel, Tadeuz J, Morrison, Amy C, Perkins, T Alex, Reiner, Robert C, Scott, Thomas W, Sihuincha, Moises, Smith, David L, Stancil, Jeffrey D, Stoddard, Steven T, Vazquez-Prokopec, Gonzalo M   +12 more
core   +2 more sources