Results 91 to 100 of about 5,827,281 (280)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Improving the approach to calculating shielding in computed tomography rooms

Радиационная гигиена
The study assessed the acceptability of the currently existing approach to calculating shielding in computed tomography rooms and formulated proposals for its improvement, taking into account the parameters of research in domestic medical practice. It is
P. S. Druzhinina, L. A. Chipiga, V. Yu. Golikov, A. V. Vodovatov, S. Yu. Bazhin, E. N. Shleenkova, G. V. Berkovich, I. V. Soldatov, Z. A. Lantukh, K. V. Tolkachev   +9 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Dose selection in seamless phase II/III clinical trials based on efficacy and toxicity [PDF]

Seamless phase II/III clinical trials are attractive in development of new drugs because they accelerate the drug development process. Seamless phase II/III trials are carried out in two stages.
Kimani, Peter K.
core  

Radiation Dose.

, 2013
CTDI: computed tomography dose index, DLP: dose length product, ED: effective dose.
Min Li (12799), Hai-yang Geng (493563), Wei-lan Zhang (493562), Bo Zhang (6559), Ke Xu (134879), Yin-qiang Liang (493564), Song-bai Li (493565)   +6 more
core   +1 more source

PENGARUH VARIASI ROTATION TIME TERHADAP NILAI DLP (DOSE LENGTH PRODUCT) DAN IMAGE NOISE PADA PESAWAT MSCT 128 SLICE ( STUDI KASUS ) [PDF]

, 2016
Dose of radiation dose especially Dose Length Product (DLP) and image noise in the plane Toshiba Aquilion to do tests using variations of rotation time.
ASMAUL FAUZIYAH, 151510383031
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Dose Assessment and Evaluation of Cancer Risk due to Prevalent CT Scan Procedures

Frontiers in Biomedical Technologies
Introduction: The use of CT scan in diagnosis is increasing significantly. The purpose of This study is evaluating the normal brain and chest Computed Tomography (CT) scans at six medical imaging departments in Tehran and evaluate the radiation dose and
Atefeh Tahmasebzadeh, Hosein Kaeidi, Maryam Kaeedi, Reza Paydar   +3 more
doaj   +1 more source