Results 71 to 80 of about 6,102,153 (248)

Dose-length-product determination on cone beam computed tomography through experimental measurements and dose-area-product conversion

, 2021
The dosimetry of cone beam computed tomography (CBCT) is not fully elaborated yet, and some of these systems presents dose-area-product (DAP) values after an examination rather than, as in the case of traditional CT, the doselength- product (DLP).
Tingberg, Anders, Fransson, Veronica, Fransson, Veronica,, Tingberg, Anders,, Lund University., Anders Tingberg, Veronica Fransson   +6 more
core   +1 more source

Optimizing Radiation Dose in High-Resolution Chest CT: The Impact of Patient-Specific Factors and Size-Specific Dose Estimates

Diagnostics
Background/Objectives: High-resolution chest computed tomography (HRCT) is a critical diagnostic tool, but radiation dose optimization remains a significant concern.
Mohamed Abuzaid
doaj   +1 more source

Changes in the Diagnostic Reference Levels for Computed Tomography in Japan: A Literature Review to Guide Future Revisions [PDF]

Journal of Radiation Protection and Research
Radiation is widely used in medicine but has both benefits and risks. Three important points must be taken into account in the medical use of radiation: justification, optimization, and dose limits.
Teruo Ito
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Effective dose in paediatric computed tomography

There is limited data currently available for making dose and risk assessments for paediatric patients undergoing computed tomographic examination. A method has been developed to correlate the risk-related quantity, effective dose, to the more simply ...
Frame J, Chapple CL, Willis S
core   +4 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Dose-related hypoglycemia in venlafaxine poisoning: a retrospective cohort study

, 2022
Several case reports describe hypoglycemia in the context of venlafaxine overdose, while investigations at therapeutic dose suggested a neutral effect on glucose homeostasis. Studies on hypoglycemia in venlafaxine intoxication are lacking.
Florian Eyer (4536688), Elias Bekka (9436061)   +1 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Whole Body Low Dose Computed Tomography Using Third-Generation Dual-Source Multidetector With Spectral Shaping: Protocol Optimization and Literature Review

Dose-Response, 2020
For decades, the main imaging tool for multiple myeloma (MM) patient’s management has been the conventional skeleton survey. In 2014 international myeloma working group defined the advantages of the whole-body low dose computed tomography (WBLDCT) as a ...
Dario Baldi, Liberatore Tramontano, Vincenzo Alfano, Bruna Punzo, Carlo Cavaliere, Marco Salvatore   +5 more
doaj   +1 more source