Results 71 to 80 of about 5,827,281 (280)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Dose-time test

, 2016
Mean length of C. aspersum’s diverticulum over time when four doses of love-dart mucus of the species E.
Joris M. Koene (250439), Monica Lodi (3322374), Koene, Joris M., Lodi, Monica   +3 more
core   +1 more source

Estimation of the effective dose in torso 18F-fluorodeoxyglucose PET/CT: an analysis of real-world clinical data from 51,784 patient scans

EJNMMI Physics
Background Large-scale estimation of effective dose (ED) for positron emission tomography (PET)/computed tomography (CT) remains limited. This study aimed to determine the ED of torso 18F-fluorodeoxyglucose (FDG) PET/CT using extensive real-world ...
Jeongryul Ryu, Jungsu S. Oh, Yong-il Kim, Sangwon Han, Jae Seung Kim, Kyung-Hyun Do, Jin-Sook Ryu   +6 more
doaj   +1 more source

ASSESSMENT OF DOSE LENGTH PRODUCT IN PEDIATRIC CT (NCCT HEAD)

BACKGROUNG: Computed Tomography of the head is widely used in pediatric imaging due to its rapid acquisition and high diagnostic accuracy. However, concerns regarding radiation exposure in children remain significantly, as pediatric patients are more sensitive to ionizing radiation and have a longer lifetime risk of radiation-related effects.
Ayman Ishaq, Jamima Afrin, Mohammad Ayan, Mohd Abdullah Siddiqui   +3 more
openaire   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Radiation dose associated with common computed tomography examination

The Egyptian Journal of Radiology and Nuclear Medicine, 2017
Objective: To survey computed tomography (CT) radiation dose associated with non-contrast spiral Multislice CT examination in our institute. Methods: Detailed parameters for 362 consecutive examinations, including the patient weight, height, volume CT ...
Ayman Mokhtar, Mohamed Elawdy, Maysa Abd El-Hamid, Huda Refaie, Tarek A. El-Diasty, Sabry El Mogy   +5 more
doaj   +1 more source

Evaluation of Dose-length Product in Head Ct using Multi-detector Computed Tomography

International Journal For Multidisciplinary Research
Background: Computed Tomography (CT) is one of the most widely used imaging modalities but contributes significantly to patient radiation exposure. Multi-Detector CT (MDCT) has improved diagnostic accuracy and speed but also raised concerns about increased radiation doses.
ARIF MALLA, ASHISH SHUKLA, ABHISHEK KAUSHIK, ALEENA SYED, ANUBHAV BHARDWAJ   +4 more
openaire   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Patient factors associated with SSRI dose for depression treatment in general practice:A primary care cross sectional study [PDF]

, 2014
Background: Antidepressant prescribing continues to rise. Increased long-term prescribing and higher doses are contributing to current growth; however, patient factors associated with the use of higher doses remain unknown.
Brian Williams, Dougall, Nadine J., Chris F Johnson, Buchanan, Alasdair I, Stephen A MacGillivray, MacGillivray, Stephen A, Dougall, Nadine J, Buchanan, Alasdair I., Dougall, Nadine, Nadine J Dougall, Hassett, Richard D, Johnson, Chris F, Williams, Brian, Johnson, Chris F., Hassett, Richard D., MacGillivray, Stephen A.; id_orcid, Alasdair I Buchanan, MacGillivray, Steve, Richard D Hassett   +18 more
core   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source