Results 61 to 70 of about 6,102,153 (248)

Adult Computed Tomography examinations in Uganda: Towards determining the National Diagnostic Reference Levels

BMC Medical Imaging, 2022
Introduction Diagnostic Reference Levels (DRLs), typically set at the 75th percentile of the dose distribution from surveys conducted across a broad user base using a specified dose-measurement protocol, are recommended for radiological examinations ...
Geoffrey Erem, Faith Ameda, Caroline Otike, William Olwit, Aloysius G. Mubuuke, Cyril Schandorf, Akisophel Kisolo, Michael G. Kawooya   +7 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Estimation of the effective dose in torso 18F-fluorodeoxyglucose PET/CT: an analysis of real-world clinical data from 51,784 patient scans

EJNMMI Physics
Background Large-scale estimation of effective dose (ED) for positron emission tomography (PET)/computed tomography (CT) remains limited. This study aimed to determine the ED of torso 18F-fluorodeoxyglucose (FDG) PET/CT using extensive real-world ...
Jeongryul Ryu, Jungsu S. Oh, Yong-il Kim, Sangwon Han, Jae Seung Kim, Kyung-Hyun Do, Jin-Sook Ryu   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A survey of computed tomography dose index and dose length product level in usual computed tomography protocol [PDF]

, 2018
Background: Nowadays, the use of computed tomography (CT) as a diagnostic tool has been considerably increased. Therefore, implementation of the program to conform the protection regulations on the CT scan is necessary to reduce the detrimental ...
Mihandoost, E., Mohseni, M., Aliasgharzadeh, A.   +2 more
core  

Dose calculations for [¹³¹I] meta-iodobenzylguanidine-induced bystander effects

, 2014
Targeted radiotherapy is a potentially useful treatment for some cancers and may be potentiated by bystander effects. However, without estimation of absorbed dose, it is difficult to compare the effects with conventional external radiation treatment ...
R. J. Mairs, Seymour, C B, M. D. Gow, Mairs, R J, C. B. Seymour, Gow, M.D., Mothersill, C.E., Seymour, C.B., C. E. Mothersill, Mairs, R.J., M. Boyd, W. V. Prestiwch, Mothersill, C E, Prestiwch, W V, Prestiwch, W.V., Boyd, Marie, Boyd, M., Gow, M D   +17 more
core   +1 more source

Comparative study of the efficacy of olmesartan/amlodipine vs. perindopril/amlodipine in peripheral blood pressure after missed dose in type 2 diabetes [PDF]

, 2016
INTRODUCTION: Combination therapy is needed to control blood pressure (BP) in a large number of hypertensive patients with diabetes mellitus. Adherence to treatment is a major clinical problem; therefore, the time duration of the antihypertensive action ...
Pichler G, Redon J, Missed Dose Study Group, Sarzani Riccardo   +3 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Dose-time test

, 2016
Mean length of C. aspersum’s diverticulum over time when four doses of love-dart mucus of the species E.
Joris M. Koene (250439), Monica Lodi (3322374), Koene, Joris M., Lodi, Monica   +3 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source