Results 61 to 70 of about 5,827,281 (280)

Complexity of Constraint Satisfaction Problems over Finite Subsets of Natural Numbers [PDF]

open access: yes, 2016
We study the computational complexity of constraint satisfaction problems that are based on integer expressions and algebraic circuits. On input of a finite set of variables and a finite set of constraints the question is whether the variables can be ...
Dose, Titus
core   +1 more source

An Analysis of Computed Tomography Diagnostic Reference Levels in India Compared to Other Countries

open access: yesDiagnostics
Computed Tomography (CT) is vital for diagnosing and monitoring medical conditions. However, increased usage raises concerns about patient radiation exposure. Diagnostic Reference Levels (DRLs) aim to minimize radiation doses in CT imaging.
Maajid Mohi Ud Din Malik   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

P-Optimal Proof Systems for Each NP-Set but no Complete Disjoint NP-Pairs Relative to an Oracle [PDF]

open access: yes, 2019
Pudlák [P. Pudlák, 2017] lists several major conjectures from the field of proof complexity and asks for oracles that separate corresponding relativized conjectures.
Dose, Titus
core   +1 more source

Advanced Computational Methods for Radiation Dose Optimization in CT

open access: yesDiagnostics
Background: In planning radiotherapy treatments, computed tomography (CT) has become a crucial tool. CT scans involve exposure to ionizing radiation, which can increase the risk of cancer and other adverse health effects in patients.
Shreekripa Rao   +11 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Establishment of Local Diagnostic Reference Levels for Pediatric Head CT at a South African Tertiary Hospital

open access: yesBrazilian Journal of Radiation Sciences
Computed tomography (CT) provides rapid, high-resolution 3D imaging, reducing motion artifacts and the need for sedation in pediatric patients. However, children are highly sensitive to ionizing radiation due to their developing tissues and longer life ...
Mpumelelo Nyathi   +1 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Dose-related hypoglycemia in venlafaxine poisoning: a retrospective cohort study

open access: yes, 2022
Several case reports describe hypoglycemia in the context of venlafaxine overdose, while investigations at therapeutic dose suggested a neutral effect on glucose homeostasis. Studies on hypoglycemia in venlafaxine intoxication are lacking.
Florian Eyer (4536688)   +1 more
core   +1 more source

Adult Computed Tomography examinations in Uganda: Towards determining the National Diagnostic Reference Levels

open access: yesBMC Medical Imaging, 2022
Introduction Diagnostic Reference Levels (DRLs), typically set at the 75th percentile of the dose distribution from surveys conducted across a broad user base using a specified dose-measurement protocol, are recommended for radiological examinations ...
Geoffrey Erem   +7 more
doaj   +1 more source

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