Results 51 to 60 of about 6,102,153 (248)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

An Analysis of Computed Tomography Diagnostic Reference Levels in India Compared to Other Countries

Diagnostics
Computed Tomography (CT) is vital for diagnosing and monitoring medical conditions. However, increased usage raises concerns about patient radiation exposure. Diagnostic Reference Levels (DRLs) aim to minimize radiation doses in CT imaging.
Maajid Mohi Ud Din Malik, Mansour Alqahtani, Ibrahim Hadadi, Abdullah G. M. AlQhtani, Abdullah Alqarni   +4 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Results from group comparison of radiation dose (unpaired t-test).

, 2014
Data are means±standard deviations.CDTI = Computed Tomography Dose Index (mGy); DLP = Dose Length Product (mGy*cm); ED = estimated effective dose (mSv).
Sylvia Unterhumer (576235), Richard Nolz (576234), Christian Loewe (576239), Rüdiger Schernthaner (576237), Veronika Schöpf (475893), Michael Weber (134225), Florian Wolf (576238), Christina Plank (576236), Dietrich Beitzke (576233)   +8 more
core   +1 more source

Advanced Computational Methods for Radiation Dose Optimization in CT

Diagnostics
Background: In planning radiotherapy treatments, computed tomography (CT) has become a crucial tool. CT scans involve exposure to ionizing radiation, which can increase the risk of cancer and other adverse health effects in patients.
Shreekripa Rao, Krishna Sharan, Srinidhi Gururajarao Chandraguthi, Rechal Nisha Dsouza, Leena R. David, Sneha Ravichandran, Mubarak Taiwo Mustapha, Dilip Shettigar, Berna Uzun, Rajagopal Kadavigere, Suresh Sukumar, Dilber Uzun Ozsahin   +11 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Mean, median and dispersion of dose length product (mGy.cm) according to CT scanning protocol before and after the introduction of iterative reconstruction (iDose).

, 2015
n = Number of cases included in analysis. Min = Minimum value, Max = Maximum value.Mean, median and dispersion of dose length product (mGy.cm) according to CT scanning protocol before and after the introduction of iterative reconstruction (iDose).
David A. J. Gibson (570345), Richard Fox (153532), Rene K. Forsyth (570346), Rachael E. Moorin (314872)   +3 more
core   +1 more source

ESTIMATION OF EFFECTIVE DOSE AND CANCER RISK OF LUMBAR SPINE CT PATIENTS USING DOSE LENGHT PRODUCT AND CONVERSION FACTORS: RETROSPECTIVE STUDY

, 2013
The purpose of this study is to estimate effective radiation dose and risk ratio induction of cancer for lumbar spine CT examination with computed tomography dose index (CTDI) and dose-length product (DLP) patient dose ...
Kandemir, RECEP, ADA, EMEL
core   +1 more source

Establishment of Local Diagnostic Reference Levels for Pediatric Head CT at a South African Tertiary Hospital

Brazilian Journal of Radiation Sciences
Computed tomography (CT) provides rapid, high-resolution 3D imaging, reducing motion artifacts and the need for sedation in pediatric patients. However, children are highly sensitive to ionizing radiation due to their developing tissues and longer life ...
Mpumelelo Nyathi, Autherlia Dimpho Rinkie Mosiame   +1 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source