Results 61 to 70 of about 7,945,859 (267)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Dose-ResponseThe validity of the linear-no-threshold (LNT) model in radiation regulation remains contested. Although extensive experimental evidence challenges it, epidemiological studies—especially cohort and case-control designs—are still used to justify its ...
Duk-Hee Lee
doaj +1 more source
Observations on the Chernobyl Disaster and LNT
Dose-Response, 2010 The Chernobyl accident was probably the worst possible catastrophe of a nuclear power station. It was the only such catastrophe since the advent of nuclear power 55 years ago.
Zbigniew Jaworowski
doaj +1 more source
, 2005 Dose-response data for many chemical carcinogens exhibit multiple apparent concentration thresholds. A relatively small increase in exposure concentration near such a threshold disproportionately increases incidence of a specific tumor type.
Louis Anthony (Tony) Cox
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Optimal designs for estimating critical effective dose under model uncertainty in a dose response study [PDF]
Toxicologists have been increasingly using a class of models to describe a continuous response in the last few years. This class consists of nested nonlinear models and is used for estimating various parameters in the models or some meaningful function ...
Shpilev, Piter +3 more
core +2 more sources
Dose-ResponsePurpose This work was the first study to show the impact of γ- radiation on adropin levels in the serum and liver tissue of male albino rats. Methods Liver tissue and blood samples of rats were collected at 1, 3, 7 and 14 days after whole-body exposure ...
Nadia Abdel-Magied +4 more
doaj +1 more source
Association between Local External Gamma Rays and Frequency of Cancer in Babol-Iran
Dose-Response, 2010 Introduction The effect of natural background radiation on Cancer is still challenging. The investigation of association between external gamma rays and Cancer was the main goal of study.
Ali Shabestani Monfared +3 more
doaj +1 more source
Optimal designs for dose-response models with restricted design spaces [PDF]
In dose response studies, the dose range is often restricted due to concerns over drug toxicity and/or efficacy. We present restricted and unrestricted interval locally optimal designs with respect to a very general class of optimality criteria for ...
Zhu, Wei +2 more
core
, 2008 Prior work has provided incremental phases to a microdosimetry modeling program to describe the dose response behavior of the radio-protective adaptive response effect.
Bobby E. Leonard
core +1 more source