Results 81 to 90 of about 7,945,859 (267)
Tumor Resistance Explained by Hormesis
Dose-Response, 2010 Enhanced drug (GDC 0449) resistance in a mouse model for human medulloblastoma is shown in the present paper to act via an hormetic response. This has significant implications, imposing constraints on the quantitative features of the dose response of the
Edward J. Calabrese Ph.D. +1 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Dose-Response, 2010 Based on the cooperative virulence index ( c.f. ) and LC 50 of fipronil, the interaction effect between short-term heat pretreatment and fipronil on 2 nd instar larvae of diamondback moth (DBM), Plutella xylostella (Linnaeus), was assessed.
Xiaojun Gu +4 more
doaj +1 more source
Compound Optimal Designs for Percentile Estimation in Dose-Response Models with Restricted Design Intervals [PDF]
In dose-response studies, the dose range is often restricted due to ethics concerns over drug toxicity and/or efficacy, particularly when human subjects are involved.
Zhu, Wei +2 more
core
Dose-response profile (contrast patterns).
, 2018 Dose-response profile (contrast patterns).
Tadao Akizawa (316095) +2 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Radiation Responses of Human Mesenchymal Stem Cells Derived From Different Sources
Dose-Response, 2019 Mesenchymal stem cells (MSCs) derived from different tissues may aid in the regeneration of radiation-induced organ lesions; however, the radiation responses of human MSCs from different sources are unknown. In our study, a comparison of the results from
Ningning He +12 more
doaj +1 more source
Optimal designs for dose finding studies [PDF]
Identifying the "right" dose is one of the most critical and difficult steps in the clinical development process of any medicinal drug. Its importance cannot be understated: selecting too high a dose can result in unacceptable toxicity and associated ...
Dette, Holger, Bretz, Frank
core
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
What Can Chemical Carcinogenesis Shed Light on the LNT Hypothesis in Radiation Carcinogenesis?
Dose-Response, 2019 To protect the public’s health from exposure to physical, chemical, and microbiological agents, it is important that any policy be based on rigorous scientifically based research. The concept of “linear no-threshold” (LNT) has been implemented to provide
James E. Trosko
doaj +1 more source