The relationship between tacrolimus concentration-dose ratio and genetic polymorphism in patients subjected to renal transplantation [PDF]
Vojnosanitetski Pregled, 2018 Background/Aim. Tacrolimus concentration-dose ratio as a potential therapeutic drug monitoring strategy was suggested to be used for the patients subjected to renal transplantation.
Rančić Nemanja +7 more
doaj +1 more source
Chronic inducible urticaria: confirmation through challenge tests and response to treatment
Einstein (São Paulo), 2020 Objective To evaluate the positivity of challenge tests of patients suspected of chronic inducible urticaria and the response to treatment. Methods A retrospective study of electronic medical records of patients suspected of chronic inducible ...
Amanda Rocha Firmino Pereira +3 more
doaj +2 more sources
Effect of fixed-dose subcutaneous reslizumab on asthma exacerbations in patients with severe uncontrolled asthma and corticosteroid sparing in patients with oral corticosteroid-dependent asthma : results from two phase 3, randomised, double-blind, placebo-controlled trials [PDF]
, 2020 BACKGROUND: Reslizumab 3 mg/kg administered intravenously is approved for the treatment of severe eosinophilic asthma. We assessed the safety and efficacy of subcutaneous reslizumab 110 mg in two trials in patients with uncontrolled severe asthma and ...
Adir, Yochai +13 more
core +1 more source
Brazilian Journal of Anesthesiology, 2022 Background: We aimed to determine the minimum effective volume (MEV) of 0.5% bupivacaine for infraclavicular brachial plexus block. Methods: We assigned patients to volume groups consisting of five consecutive patients.
Semih Başkan +3 more
doaj +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2023 Dose–response analysis is often applied to the quantification of drug‐effect especially for slowly responding disease end points where a comparison is made across dose levels after a particular period of treatment.
James W. T. Yates, Hitesh B. Mistry
doaj +1 more source
Medicina, 2023 Background and Objectives: The dose selection for isobaric bupivacaine determines the success of spinal anesthesia (SA). A dose higher than the optimal dose causes high SA, whereas an underdose leads to inadequate spread of cephalad.
Ornwara Visavakul +5 more
doaj +1 more source
Model Selection versus Model Averaging in Dose Finding Studies [PDF]
, 2015 Phase II dose finding studies in clinical drug development are typically conducted to adequately characterize the dose response relationship of a new drug.
Bornkamp, Björn +3 more
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The dose-response relationship for memory impairment by anticholinergic drugs
Comprehensive Psychiatry, 1989 Twelve stabilized chronic schizophrenic outpatients receiving maintenance treatment with fluphenazine decanoate plus anticholinergic antiparkinsonian drugs underwent two challenge sessions receiving, in random sequence and double-blind, injections of either benztropine or glycopyrrolate (a peripherally active anticholinergic agent that penetrates the ...
J P, McEvoy, S, Freter
openaire +2 more sources
Cancer Biology & Medicine, 2010 OBJECTIVE To investigate an initial approach of radiotherapy, which produces cellular radiation injury by high dose in one fraction. METHODS Human pancreatic carcinoma cell line MIA PaCa-2, was cultivated and divided into 5 groups: 0, 2, 5, 10, 17 ...
Ping WANG +3 more
doaj +1 more source
Design considerations and analysis planning of a phase 2a proof of concept study in rheumatoid arthritis in the presence of possible non-monotonicity [PDF]
, 2017 BACKGROUND: It is important to quantify the dose response for a drug in phase 2a clinical trials so the optimal doses can then be selected for subsequent late phase trials.
AE Raftery +17 more
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