A Review of the Dose Justification of Phase 3 Trials to Regulatory Authorities for Drugs Intended for the Treatment of Type 2 Diabetes in Europe [PDF]
Frontiers in Pharmacology, 2021 Aims: Cardiovascular outcome trials with anti-diabetic drugs suggest that additional cardiovascular benefit can be achieved independent of improving glycaemic control.
Heerspink, Hiddo J L +4 more
core +3 more sources
Multi-output prediction of dose–response curves enables drug repositioning and biomarker discovery [PDF]
npj Precision OncologyDrug response prediction is hampered by uncertainty in the measures of response and selection of doses. In this study, we propose a probabilistic multi-output model to simultaneously predict all dose–responses and uncover their biomarkers.
Chen, Yurui +6 more
core +3 more sources
Dose Optimisation and Scarce Resource Allocation: Two Sides of the Same Coin [PDF]
BMJ Open, 2022 Objective: A deep understanding of the relationship between a scarce drug\u27s dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines. Summary of key data: The vast majority of drug development and
Murthy, Srinivas +3 more
core +4 more sources
Design considerations and analysis planning of a phase 2a proof of concept study in rheumatoid arthritis in the presence of possible non-monotonicity [PDF]
BMC Medical Research Methodology, 2017 BACKGROUND: It is important to quantify the dose response for a drug in phase 2a clinical trials so the optimal doses can then be selected for subsequent late phase trials.
AE Raftery +17 more
core +4 more sources
A simple calculation of the maximum dose of the local anesthetic in pediatric dentistry with nomogram [PDF]
Vojnosanitetski Pregled, 2022 nema
Mladenović Raša
doaj +1 more source
Evaluating the relationship between Ex3 vNTR and rs3758653 polymorphisms in DRD4 genes in children with attention deficit hyperactivity disorder with respect to the dose of methylphenidate [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2022 Background. Attention deficit hyperactivity disorder (ADHD) is one of the most common psychiatric disorders starting at an early age with symptoms of attention deficit hyperactivity disorder and impulsivity.
Shahrokh Amiri +5 more
doaj +1 more source
Adverse effects of long term, continual administration of high doses of albendazole in the treatment of echinococcal disease [PDF]
Vojnosanitetski Pregled, 2008 Background/Aim. Modern treatment of cystic echinococcosis, except for surgical treatment and percutaneous drainage of cyst considers also administration of albendazole as a type of individual therapy.
Jevtić Miodrag +6 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Traditional methods to standardize exposures in pharmacoepidemiologic studies, like defined daily-doses, may be inadequate to capture drug class effects when there are many in-class medications, formulations, and administration routes.
Kaleen N. Hayes +8 more
doaj +1 more source
The c.-1639g>A polymorphism of the VKORC1 gene and his influence on the therapeutic response during oral anticoagulants use [PDF]
Vojnosanitetski Pregled, 2009 Background/Aim. A single nucleotide polymorphism c.- 1639G>A in the promoter region of vitamin K-epoxide reductase (VKORC1) gene has been found to account for most of the variability in response to oral anticoagulants (OA). The aim of the study was to
Kovač Mirjana +3 more
doaj +1 more source
Histopathologic investigations of nifedipine-induced gingival hyperplasia in Wistar rats [PDF]
Vojnosanitetski Pregled, 2005 Background. Nifedipine, a calcium channel blocker, used in the therapy of cardiovascular diseases, can induce gingival overgrowth. The aim of the study was to assess the influence of nifedipine on the deeper periodontal tissues of the experimental ...
Brkić Zlata
doaj +1 more source