Results 271 to 280 of about 707,752 (308)
Some of the next articles are maybe not open access.
Dose-response relationships with antihypertensive drugs
Pharmacology & Therapeutics, 1992A variety of antihypertensive drugs have been introduced into clinical practice at excessively high dose. Examples include most thiazide diuretics, propranolol, oxprenolol, atenolol, methyldopa, hydralazine and captopril. These very high doses have usually resulted from studies in which doses have been increased at regular intervals until the desired ...
openaire +2 more sources
Cellular and Molecular Bioengineering, 2021
Ischemic stroke treatment has advanced in the last two decades and intravenous thrombolysis is now considered the standard of care for selected patients. Recanalization can also be achieved by mechanical endovascular treatment for patients with large vessel occlusions.
Chi Hang Chon +5 more
openaire +4 more sources
Ischemic stroke treatment has advanced in the last two decades and intravenous thrombolysis is now considered the standard of care for selected patients. Recanalization can also be achieved by mechanical endovascular treatment for patients with large vessel occlusions.
Chi Hang Chon +5 more
openaire +4 more sources
Drug Action: Target Tissue, Dose-Response Relationships, and Receptors
1972In the complex processes of drug action three main phases can be distinguished (Fig. 1): the pharmaceutical phase, the pharmacokinetic phase and the pharmacodynamic phase. They form a suitable frame for the discussion of the chemical basis of drug action.
A. M. Simonis, Ariens Ej
openaire +2 more sources
Journal of Psychoactive Drugs, 1995
This study examined the impact of treatment intensity on cocaine use. Seventy-seven cocaine-using methadone patients were enrolled in a six-month, structured, manual-driven, cognitive-behavioral treatment program. Sessions consisted of five individual and/or group sessions per week.
Barry Stimmel +6 more
openaire +3 more sources
This study examined the impact of treatment intensity on cocaine use. Seventy-seven cocaine-using methadone patients were enrolled in a six-month, structured, manual-driven, cognitive-behavioral treatment program. Sessions consisted of five individual and/or group sessions per week.
Barry Stimmel +6 more
openaire +3 more sources
AAPS PharmSciTech, 2023
The objective of this study is to investigate the dose-response relationship between various concentrations of permeation enhancers (PEs) and their ability to enhance drug release from a polymer matrix, utilizing an innovative parameter known as release enhancement efficiency (K). Additionally, the molecular mechanism underlying dynamic enhancement was
Jiuheng Ruan +3 more
openaire +2 more sources
The objective of this study is to investigate the dose-response relationship between various concentrations of permeation enhancers (PEs) and their ability to enhance drug release from a polymer matrix, utilizing an innovative parameter known as release enhancement efficiency (K). Additionally, the molecular mechanism underlying dynamic enhancement was
Jiuheng Ruan +3 more
openaire +2 more sources
Drug Metabolism and Disposition, 1991
A monoclonal antibody was used to study the dose-response relationship for antibody-mediated redistribution of tricyclic antidepressants (TCA) in rats. The antibody (anti-TCA) was an IgG1 with Ka = 3.0 x 10(8) M-1 for desipramine (DMI) and 2.2 x 10(8) M-1 for imipramine (IMI).
P R, Pentel +6 more
openaire +2 more sources
A monoclonal antibody was used to study the dose-response relationship for antibody-mediated redistribution of tricyclic antidepressants (TCA) in rats. The antibody (anti-TCA) was an IgG1 with Ka = 3.0 x 10(8) M-1 for desipramine (DMI) and 2.2 x 10(8) M-1 for imipramine (IMI).
P R, Pentel +6 more
openaire +2 more sources
The Journal of Clinical Pharmacology, 2012
The contribution of specific psychotropic drugs to fall risk in patients with dementia has not been quantified precisely until now. The authors evaluated the dose‐response relationship between psychotropic drugs and falls in nursing home residents with dementia.
Mirko Petrovic +6 more
openaire +3 more sources
The contribution of specific psychotropic drugs to fall risk in patients with dementia has not been quantified precisely until now. The authors evaluated the dose‐response relationship between psychotropic drugs and falls in nursing home residents with dementia.
Mirko Petrovic +6 more
openaire +3 more sources
2021
The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world's population is estimated to be latently infected. Drug development and screening is slow and costly. We have developed a physiologically relevant assay to screen drugs against TB when inside immune cells.
C. Martínez-Rodríguez +3 more
openaire +3 more sources
The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world's population is estimated to be latently infected. Drug development and screening is slow and costly. We have developed a physiologically relevant assay to screen drugs against TB when inside immune cells.
C. Martínez-Rodríguez +3 more
openaire +3 more sources
Effects of drugs on nondiscriminated avoidance behavior
Psychopharmacologia, 1964Thirteen male, Long-Evans rats were trained to press a lever to postpone a brief electric shock. Each rat was subjected to several different doses of chlorpromazine, d-amphetamine, atropine and benactyzine, and then tested for four hours under a mixed schedule of extinction and nondiscriminated avoidance behavior.
openaire +3 more sources
Pharmacogenetics and Genetic Factors in Drug Dose-Response Relationships
2023Abstract Pharmacogenetics and pharmacogenomics are related areas of research that aim to determine the relationship between genotypic variation, including changes in gene expression, and variations in drug response seen across patient groups. Understanding the genetic bases of variability in drug response due to altered pharmacokinetics (
openaire +1 more source