Results 271 to 280 of about 734,043 (307)
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Naunyn-Schmiedeberg's Archives of Pharmacology, 2007
The objective of this study was to characterize the anticonvulsant and acute adverse-effect potentials of topiramate (TPM) and gabapentin (GBP)-two second-generation antiepileptic drugs administered alone and in combination in the maximal electroshock (MES)-induced seizures and chimney test in mice.
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The objective of this study was to characterize the anticonvulsant and acute adverse-effect potentials of topiramate (TPM) and gabapentin (GBP)-two second-generation antiepileptic drugs administered alone and in combination in the maximal electroshock (MES)-induced seizures and chimney test in mice.
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PhXA34, a New Potent Ocular Hypotensive Drug
Archives of Ophthalmology, 1991The prostaglandin analogue PhXA34 was tested in two studies in normal human eyes; 1, 3, and 10 micrograms of PhXA34 reduced the intraocular pressure by about 2, 3, and 4 mm Hg, respectively, 6 to 10 hours after a single topical dose. The only side effect observed was a slight conjunctival hyperemia after 10 micrograms of PhXA34.
Albert Alm, Jörgen Villumsen
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Toxic Effects of Nonsteroidal Anti-Inflammatory Drugs in Overdose
Drug Safety, 1990Nonsalicylate, nonsteroidal anti-inflammatory drugs (NSAIDs) can be divided into 4 chemical classes: acetic acids, fenamic acids, oxicams and propionic acids. Most NSAID overdoses result in a benign outcome. Of 50,614 exposures reported to poison centres in the United States in a 2-year period, 131 (0.26%) had a major outcome, with 10 deaths.
Susan C. Smolinske +4 more
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Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1997
1. From a review of published literature it is concluded that the minimum dose of a neuroleptic drug (NLD) required to alleviate psychosis is very similar to that producing minimal parkinsonian side effects (PSE). This conclusion is reached both from group comparisons and individual comparisons of dose/response relations (DRR) for the two effects. 2. A
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1. From a review of published literature it is concluded that the minimum dose of a neuroleptic drug (NLD) required to alleviate psychosis is very similar to that producing minimal parkinsonian side effects (PSE). This conclusion is reached both from group comparisons and individual comparisons of dose/response relations (DRR) for the two effects. 2. A
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Arthritis Care & Research, 2017
ObjectiveTo investigate a possible short‐term dose‐response relationship of initial treatment with methotrexate (MTX) in monotherapy and combination therapy in recent‐onset rheumatoid arthritis (RA) patients.MethodsA systematic literature search was performed on trials and cohorts, including early, disease‐modifying antirheumatic drug (DMARD)–naive RA ...
Bergstra, S.A. +3 more
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ObjectiveTo investigate a possible short‐term dose‐response relationship of initial treatment with methotrexate (MTX) in monotherapy and combination therapy in recent‐onset rheumatoid arthritis (RA) patients.MethodsA systematic literature search was performed on trials and cohorts, including early, disease‐modifying antirheumatic drug (DMARD)–naive RA ...
Bergstra, S.A. +3 more
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Acta Diabetologica, 1998
The aim of this double-blind, placebo-controlled, multinational, five-arm study was to investigate the dose-response relationship of acarbose as a first-line drug in the treatment of type 2 diabetes (non-insulin dependent) over a range of minimal and maximal doses according to the European recommendations.
M. Spengler +4 more
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The aim of this double-blind, placebo-controlled, multinational, five-arm study was to investigate the dose-response relationship of acarbose as a first-line drug in the treatment of type 2 diabetes (non-insulin dependent) over a range of minimal and maximal doses according to the European recommendations.
M. Spengler +4 more
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Psychopharmacologia, 1974
Conflict behaviour in a T-maze can be observed at the choice point, involving simultaneous tendencies to move left and right and in the goal box involving simultaneous tendencies to approach the reward and to return towards the choice point. Firstly, the effects of different doses (from 0.06 to 1 mg/kg) of the cholinolytic drug 3-quinuclidinyl ...
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Conflict behaviour in a T-maze can be observed at the choice point, involving simultaneous tendencies to move left and right and in the goal box involving simultaneous tendencies to approach the reward and to return towards the choice point. Firstly, the effects of different doses (from 0.06 to 1 mg/kg) of the cholinolytic drug 3-quinuclidinyl ...
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[Age as a factor in dose-response relationship of drugs].
Zeitschrift fur Gerontologie und Geriatrie, 1996Drug therapy in the elderly requires careful individualization of the dosage. Whether dose adjustment is due to altered pharmacokinetic or due to altered pharmacodynamic is a matter of experimental evidence which can be found by performing studies with simultaneous measurements of concentration and effect over time.
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[Timed dose-response relationship analysis of pressor and hypotensive action of drugs].
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1993The graded and timed dose-response relationship (TDRR) of pressor and hypotensive action by i.v. norepinephrine (NE) and sodium nitroprusside (SNP) respectively were studied in 13 male rabbits. The arterial blood pressure was dose-dependently raised by NE 0.98-125 micrograms.kg-1 and lowered by SNP 7.81-500 micrograms.kg-1 (F test, P < 0.01).
M Y, Wang, J Q, Zheng, B A, Wang
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
exaly