Results 271 to 280 of about 756,046 (308)
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2021
The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world's population is estimated to be latently infected. Drug development and screening is slow and costly. We have developed a physiologically relevant assay to screen drugs against TB when inside immune cells.
Samantha, Donnellan +3 more
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The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world's population is estimated to be latently infected. Drug development and screening is slow and costly. We have developed a physiologically relevant assay to screen drugs against TB when inside immune cells.
Samantha, Donnellan +3 more
openaire +2 more sources
The Journal of Clinical Pharmacology, 2012
The contribution of specific psychotropic drugs to fall risk in patients with dementia has not been quantified precisely until now. The authors evaluated the dose‐response relationship between psychotropic drugs and falls in nursing home residents with dementia.
Sterke, Shanty +6 more
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The contribution of specific psychotropic drugs to fall risk in patients with dementia has not been quantified precisely until now. The authors evaluated the dose‐response relationship between psychotropic drugs and falls in nursing home residents with dementia.
Sterke, Shanty +6 more
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Naunyn-Schmiedeberg's Archives of Pharmacology, 2007
The objective of this study was to characterize the anticonvulsant and acute adverse-effect potentials of topiramate (TPM) and gabapentin (GBP)-two second-generation antiepileptic drugs administered alone and in combination in the maximal electroshock (MES)-induced seizures and chimney test in mice.
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The objective of this study was to characterize the anticonvulsant and acute adverse-effect potentials of topiramate (TPM) and gabapentin (GBP)-two second-generation antiepileptic drugs administered alone and in combination in the maximal electroshock (MES)-induced seizures and chimney test in mice.
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[Timed dose-response relationship analysis of pressor and hypotensive action of drugs].
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1993The graded and timed dose-response relationship (TDRR) of pressor and hypotensive action by i.v. norepinephrine (NE) and sodium nitroprusside (SNP) respectively were studied in 13 male rabbits. The arterial blood pressure was dose-dependently raised by NE 0.98-125 micrograms.kg-1 and lowered by SNP 7.81-500 micrograms.kg-1 (F test, P < 0.01).
M Y, Wang, J Q, Zheng, B A, Wang
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The Journal of Pharmacology and Experimental Therapeutics, 1988
We have developed a 2-week bioassay that quantitates the effect of immunosuppressive drugs on organ allograft rejection. This assay is not only rapid and reliable, but also simple and relatively inexpensive and sparing of test substances. We refined the method by which neonatal mouse hearts are transplanted into pouches in the pinnae of ears of adult ...
G, Babany +3 more
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We have developed a 2-week bioassay that quantitates the effect of immunosuppressive drugs on organ allograft rejection. This assay is not only rapid and reliable, but also simple and relatively inexpensive and sparing of test substances. We refined the method by which neonatal mouse hearts are transplanted into pouches in the pinnae of ears of adult ...
G, Babany +3 more
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Effects of drugs on nondiscriminated avoidance behavior
Psychopharmacologia, 1964Thirteen male, Long-Evans rats were trained to press a lever to postpone a brief electric shock. Each rat was subjected to several different doses of chlorpromazine, d-amphetamine, atropine and benactyzine, and then tested for four hours under a mixed schedule of extinction and nondiscriminated avoidance behavior.
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Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1997
1. From a review of published literature it is concluded that the minimum dose of a neuroleptic drug (NLD) required to alleviate psychosis is very similar to that producing minimal parkinsonian side effects (PSE). This conclusion is reached both from group comparisons and individual comparisons of dose/response relations (DRR) for the two effects. 2. A
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1. From a review of published literature it is concluded that the minimum dose of a neuroleptic drug (NLD) required to alleviate psychosis is very similar to that producing minimal parkinsonian side effects (PSE). This conclusion is reached both from group comparisons and individual comparisons of dose/response relations (DRR) for the two effects. 2. A
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PhXA34, a New Potent Ocular Hypotensive Drug
Archives of Ophthalmology, 1991The prostaglandin analogue PhXA34 was tested in two studies in normal human eyes; 1, 3, and 10 micrograms of PhXA34 reduced the intraocular pressure by about 2, 3, and 4 mm Hg, respectively, 6 to 10 hours after a single topical dose. The only side effect observed was a slight conjunctival hyperemia after 10 micrograms of PhXA34.
A, Alm, J, Villumsen
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[Age as a factor in dose-response relationship of drugs].
Zeitschrift fur Gerontologie und Geriatrie, 1996Drug therapy in the elderly requires careful individualization of the dosage. Whether dose adjustment is due to altered pharmacokinetic or due to altered pharmacodynamic is a matter of experimental evidence which can be found by performing studies with simultaneous measurements of concentration and effect over time.
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Psychopharmacologia, 1974
Conflict behaviour in a T-maze can be observed at the choice point, involving simultaneous tendencies to move left and right and in the goal box involving simultaneous tendencies to approach the reward and to return towards the choice point. Firstly, the effects of different doses (from 0.06 to 1 mg/kg) of the cholinolytic drug 3-quinuclidinyl ...
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Conflict behaviour in a T-maze can be observed at the choice point, involving simultaneous tendencies to move left and right and in the goal box involving simultaneous tendencies to approach the reward and to return towards the choice point. Firstly, the effects of different doses (from 0.06 to 1 mg/kg) of the cholinolytic drug 3-quinuclidinyl ...
openaire +2 more sources