Sugammadex ED90 dose to reverse the rocuronium neuromuscular blockade in obese patients
Revista do Colégio Brasileiro de CirurgiõesObjective: to determine the ED90 (minimum effective dose in 90% of patients) of sugammadex for the reversal of rocuronium-induced moderate neuromuscular blockade (NMB) in patients with grade III obesity undergoing bariatric surgery.
MAURO PRADO DA SILVA +5 more
doaj +1 more source
Frontiers in Pharmacology, 2014 Although many antipsychotics can reasonably control positive symptoms in schizophrenia, patients’ return to society is often hindered by negative symptoms and cognitive deficits.
Hugo eGeerts +4 more
doaj +1 more source
The Dose‐Response Relationship of Tranexamic Acid
Anesthesiology, 1995 Background: Prophylactic administration of the autifibrinolytic drug tranexamic acid decreases bleeding and transfusions after cardiac operations. However, the best dose of tranexamic acid for this purpose remains unknown.
J. Horrow +4 more
semanticscholar +2 more sources
Aspects of the Relationship between Drug Dose and Drug Effect
Dose-Response, 2009 It is generally assumed that there exists a well-defined relationship between drug dose and drug effect and that this can be expressed by a dose-response curve.
Abraham Peper
doaj +1 more source
Self-supervised Learning for Label Sparsity in Computational Drug Repositioning [PDF]
arXiv, 2022 The computational drug repositioning aims to discover new uses for marketed drugs, which can accelerate the drug development process and play an important role in the existing drug discovery system. However, the number of validated drug-disease associations is scarce compared to the number of drugs and diseases in the real world.
arxiv
A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship [PDF]
, 2007 We undertook a systematic review of the pre-clinical and clinical literature for studies investigating the relationship between platinum and taxane resistance.
Davey, Ross +2 more
core +1 more source
Comparing Two Different Doses of Intravenous Midazolamin in Pediatric Sedation and Analgesia
Archives of Academic Emergency Medicine, 2018 Introduction: Midazolam has turned into a common drug for pediatric procedural sedation and analgesia. However, there is not much data regarding its proper dose and potential side effects in the Iranian children population.
Hassan Barzegari +5 more
doaj +1 more source
Estimating the turnover time of high intravenous intake of vitamin C [PDF]
Archive of Oncology, 2011 Background: Intravenous dosing is generally recognized to be the only effective means of maintaining a high concentration of vitamin C in the plasma.
Wong Alfred
doaj +1 more source
Dose Optimization of Sotorasib: Is the US Food and Drug Administration Sending a Message?
Journal of Clinical Oncology, 2021 Historically, anticancer drugs have been developed and approved for marketing on the basis of the assumption that the optimal dose is the maximum tolerated dose (MTD). That paradigm was well-suited for cytotoxic agents since those drugs typically exhibit
M. Ratain, I. Tannock, A. Lichter
semanticscholar +1 more source
Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation [PDF]
, 2018 During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the sources of
Bailey +40 more
core +3 more sources