Results 51 to 60 of about 931,718 (350)

Two-compartment pharmacokinetic model of itraconazole after single oral dose administration - gender differences [PDF]

Vojnosanitetski Pregled
Background/Aim. Itraconazole (ICZ) is a widely used antifungal drug with hypervariable pharmacokinetics (PK), which is the result of the molecule’s nature itself, as well as the influence of multiple factors.
Miljković Milijana, Kovačević Aleksandra, Mikov Momir, Stanojković Tijana, Dragojević-Simić Viktorija   +4 more
doaj   +1 more source

A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship [PDF]

, 2007
We undertook a systematic review of the pre-clinical and clinical literature for studies investigating the relationship between platinum and taxane resistance.
Davey, Ross, Pavlakis, Nick, Stordal, Britta   +2 more
core   +1 more source

Dose Optimization of Sotorasib: Is the US Food and Drug Administration Sending a Message?

Journal of Clinical Oncology, 2021
Historically, anticancer drugs have been developed and approved for marketing on the basis of the assumption that the optimal dose is the maximum tolerated dose (MTD). That paradigm was well-suited for cytotoxic agents since those drugs typically exhibit
M. Ratain, I. Tannock, A. Lichter
semanticscholar   +1 more source

Giardicidal effect of black tea (camellia sinensis) in the treatment of giardia duodenalis in swiss mice

Revista Contexto & Saúde
This study evaluated the in vivo giardicidal potential of black tea (Camellia sinensis) in male Swiss mice experimentally infected with 104 cysts of Giardia duodenalis assemblage BIV.
Liara Izabela Lopes Romera, Cristiane Maria Colli, Amanda Gubert Alves dos Santos, Gessilda de Alcântara Nogueira de Melo, Ariana Ferrari, Mônica Lúcia Gomes   +5 more
doaj   +1 more source

Estimating the turnover time of high intravenous intake of vitamin C [PDF]

Archive of Oncology, 2011
Background: Intravenous dosing is generally recognized to be the only effective means of maintaining a high concentration of vitamin C in the plasma.
Wong Alfred
doaj   +1 more source

Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation [PDF]

, 2018
During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the sources of
Bailey, Bon, Cox, Darwich, Dorey, Duwal, Ette, Fink, Jamei, Jamei, Jeunesse, Li, Li, Lin, Maaland, Margolskee, Margolskee, Martinez, Martinez, Martinez, Mochel, Mochel, Mochel, Mochel, Mochel, Mould, Ogungbenro, Pade, Pade, Paulson, Pelligand, Rey, Rostami-Hodjegan, Sheiner, Silber, Sjögren, Toutain, Tsamandouras, T’jollyn, Willmann, Zhuang   +40 more
core   +4 more sources

Dynamic tumor modeling of the dose–response relationship for everolimus in metastatic renal cell carcinoma using data from the phase 3 RECORD-1 trial

BMC Cancer, 2012
BackgroundThe phase 3 RECORD-1 trial (NCT00410124) established the efficacy and safety of everolimus in patients with metastatic renal cell carcinoma (mRCC) who progress on sunitinib or sorafenib.
A. Stein, Wenping Wang, A. Carter, O. Chiparus, N. Hollaender, Hyewon Kim, R. Motzer, C. Sarr   +7 more
semanticscholar   +1 more source

Comparing Two Different Doses of Intravenous Midazolamin in Pediatric Sedation and Analgesia

Archives of Academic Emergency Medicine, 2018
Introduction: Midazolam has turned into a common drug for pediatric procedural sedation and analgesia. However, there is not much data regarding its proper dose and potential side effects in the Iranian children population.
Hassan Barzegari, Arash Forouzan, Kambiz Masoumi, Hassan Motamed, Behzad Zohrevandi, Shima Zeynadini Meymand   +5 more
doaj   +1 more source

Change in hematologic indices over time in pediatric inflammatory bowel disease treated with azathioprine [PDF]

, 2010
Azathioprine leads to changes in mean corpuscular volume (MCV) and white blood cell (WBC) indices reflecting efficacy or toxicity. Understanding the interactions between bone marrow stem cells and azathioprine could highlight abnormal response patterns ...
A Timmer, AC Mackey, AG Fraser, Chris J. Taylor, CN Bernstein, CW Thomas Jr, David I. Campbell, DH Present, Dhandapani Ashok, I Tiede, J Glas, LJ Derijks, P Karran, S Al-Safi, Sally A. Connolly, Samantha J. Cordell, Sherman Soman, W Disanti, Y Masunaga   +18 more
core   +2 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source