Non-linear relationship of cell hit and transformation probabilities in a low dose of inhaled radon progenies [PDF]
, 2009 Cellular hit probabilities of alpha particles emitted by inhaled radon progenies in sensitive bronchial epithelial cell nuclei were simulated at low exposure levels to obtain useful data for the rejection or support of the linear-non-threshold (LNT ...
Balásházy, Imre +3 more
core +2 more sources
Genetic radiation risks: a neglected topic in the low dose debate [PDF]
Environmental Health and Toxicology, 2016 Objectives To investigate the accuracy and scientific validity of the current very low risk factor for hereditary diseases in humans following exposures to ionizing radiation adopted by the United Nations Scientific Committee on the Effects of Atomic ...
Inge Schmitz-Feuerhake +2 more
doaj +1 more source
Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Higher doses of anthracyclines and heart‐relevant radiotherapy increase cardiovascular disease (CVD) risk. This study assessed CVD and CVD risk factors among adult childhood cancer survivors (CCSs) across cardiotoxic treatment risk groups and examined associations between lifestyle behaviors and treatment risks.
Ruijie Li +6 more
wiley +1 more source
Radiotherapy Dosing for Locally Advanced Non-Small Cell Lung Carcinoma: “MTD” or “ALARA”?
Frontiers in Oncology, 2017 Locally advanced non-small cell lung cancer (LA-NSCLC) is typically treated with thoracic radiotherapy, often in combination with cytotoxic chemotherapy.
Nitin Ohri, Nitin Ohri
doaj +1 more source
The Double Threshold: Consequences for Identifying Low-Dose Radiation Effects
Dose-Response, 2020 Prior to observing low-dose-induced cell signaling and adaptive protection, radiogenic stochastic effects were assumed to be linearly related to absorbed dose.
Alan Waltar, Ludwig Feinendegen
doaj +1 more source
Opposite roles for p38MAPK-driven responses and reactive oxygen species in the persistence and resolution of radiation-induced genomic instability. [PDF]
PLoS ONE, 2014 We report the functional and temporal relationship between cellular phenotypes such as oxidative stress, p38MAPK-dependent responses and genomic instability persisting in the progeny of cells exposed to sparsely ionizing low-Linear Energy Transfer (LET ...
Erica Werner +2 more
doaj +1 more source
Dose–Response Relationship in Radiation Leukæmia: the Marking Probit
Nature, 1959 Statistical methods are applied in an analysis of data on radioinduced leukemia. It is concluded that available data do not provide statistical control of the best fit. (C.H.)
openaire +3 more sources
Effects of the Shape of the Radiation Dose-Response Curve on Public Acceptance of Radiation and Nuclear Energy [PDF]
, 2002 [Excerpt] “The public generally accepts the premise that exposure to radiation can have an undesirable effect. Furthermore, it believes that as the radiation dose increases, the magnitude of the effect will increase.
Fentiman, Audeen W.
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed +5 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source