Dose–Response Relationship in Radiation Leukæmia: the Marking Probit
Nature, 1959 Statistical methods are applied in an analysis of data on radioinduced leukemia. It is concluded that available data do not provide statistical control of the best fit. (C.H.)
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
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Radiotherapy Dosing for Locally Advanced Non-Small Cell Lung Carcinoma: “MTD” or “ALARA”?
Frontiers in Oncology, 2017 Locally advanced non-small cell lung cancer (LA-NSCLC) is typically treated with thoracic radiotherapy, often in combination with cytotoxic chemotherapy.
Nitin Ohri, Nitin Ohri
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The Double Threshold: Consequences for Identifying Low-Dose Radiation Effects
Dose-Response, 2020 Prior to observing low-dose-induced cell signaling and adaptive protection, radiogenic stochastic effects were assumed to be linearly related to absorbed dose.
Alan Waltar, Ludwig Feinendegen
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Opposite roles for p38MAPK-driven responses and reactive oxygen species in the persistence and resolution of radiation-induced genomic instability. [PDF]
PLoS ONE, 2014 We report the functional and temporal relationship between cellular phenotypes such as oxidative stress, p38MAPK-dependent responses and genomic instability persisting in the progeny of cells exposed to sparsely ionizing low-Linear Energy Transfer (LET ...
Erica Werner +2 more
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Treating cutaneous T-cell lymphoma with highly irregular surfaces with photon irradiation using rice as tissue compensator. [PDF]
, 2015 PurposeCutaneous T-cell lymphoma (CTCL) is known to have an excellent response to radiotherapy, an important treatment modality for this disease.
Chakravarti, Arnab +9 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
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Yuanzineng kexue jishuIn order to further elucidate the influence of neutron pre-irradiation on the pulse gamma ray radiation effect of NPN bipolar transistors, the photocurrent response experiments of transient ionizing radiation were performed after NPN bipolar transistors ...
LIU Weijian, LI Ruibin, GUO Xiaoqiang, LI Junlin, BAI Xiaoyan, YU Shilin
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Cancer risk estimates from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy [PDF]
, 2018 Most information on the dose-response of radiation-induced cancer is derived from data on the A-bomb survivors who were exposed to γ-rays and neutrons.
Schneider, Uwe, Walsh, Linda
core
Is There a Dose-Response Relationship for Heart Disease With Low-Dose Radiation Therapy? [PDF]
International Journal of Radiation Oncology*Biology*Physics, 2013 To quantify cardiac radiation therapy (RT) exposure using sensitive measures of cardiac dysfunction; and to correlate dysfunction with heart doses, in the setting of adjuvant RT for left-sided breast cancer.On a randomized trial, 32 women with node-positive left-sided breast cancer underwent pre-RT stress single photon emission computed tomography ...
Eugene, Chung +9 more
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