Results 61 to 70 of about 14,554,987 (328)

The Dose Window for Radiation-Induced Protective Adaptive Responses

, 2009
Adaptive responses to low doses of low LET radiation occur in all organisms thus far examined, from single cell lower eukaryotes to mammals. These responses reduce the deleterious consequences of DNA damaging events, including radiation-induced or ...
Ronald E. J. Mitchel
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Prediction of Acute Radiation Mucositis using an Oral Mucosal Dose Surface Model in Carbon Ion Radiotherapy for Head and Neck Tumors. [PDF]

PLoS ONE, 2015
To evaluate the dose-response relationship for development of acute radiation mucositis (ARM) using an oral mucosal dose surface model (OMDS-model) in carbon ion radiotherapy (C-ion RT) for head and neck tumors.Thirty-nine patients receiving C-ion RT for
Atsushi Musha, Hirofumi Shimada, Katsuyuki Shirai, Jun-Ichi Saitoh, Satoshi Yokoo, Kazuaki Chikamatsu, Tatsuya Ohno, Takashi Nakano   +7 more
doaj   +1 more source

Modeling dose-Response at Low dose: A Systems Biology Approach for Ionization Radiation

, 2010
For ionization radiation (IR) induced cancer, a linear non-threshold (LNT) model at very low doses is the default used by a number of national and international organizations and in regulatory law.
Paolo F. Ricci, Yuchao Zhao
core   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Evaluation of the Validity of a Nonlinear J-Shaped Dose-Response Relationship in Cancers Induced by Exposure to Radiofrequency Electromagnetic Fields

Journal of Biomedical Physics and Engineering, 2019
The radiofrequency electromagnetic fields (RF-EMFs) produced by widely used mobile phones are classified as possibly carcinogenic to humans by International Agency for Research on Cancer (IARC).
Mortazavi S. M. J., Mortazavi S. A. R., Haghani M.   +2 more
doaj  

Experimental Research of Pulse Gamma Ray Radiation Effect on Neutron Irradiated NPN Bipolar Transistors

Yuanzineng kexue jishu
In order to further elucidate the influence of neutron pre-irradiation on the pulse gamma ray radiation effect of NPN bipolar transistors, the photocurrent response experiments of transient ionizing radiation were performed after NPN bipolar transistors ...
LIU Weijian, LI Ruibin, GUO Xiaoqiang, LI Junlin, BAI Xiaoyan, YU Shilin
doaj   +1 more source

Dose response relationships for gamma radiation induced chromosomal instability [PDF]

, 2017
ABSTRACT Different cell lines demonstrate various dose response for radiation-induced chromosomal instability (RICI). To clarify the origin of differences we analyzed own and published data on RICI for four cell lines, V79, TK6, WTK1 and CHO-K1 on the basis of the mechanistic RICI model. We conclude that observable dose-response shapes,
Eidelman, Y.A., Slanina, S.V., Pyatenko, V.S., Khvostunov, I.K., Andreev, S.G.   +4 more
openaire   +1 more source

The dose-response relationship for cardiovascular disease is not necessarily linear

Radiation Oncology, 2017
The probability for a complication after radiotherapy is usually a function of dose and volume in the organ or tissue of interest. In most epidemiological studies the risk for a complication is stratified in terms of dose, but not irradiated volume.
U. Schneider, Marina Ernst, M. Hartmann
semanticscholar   +1 more source

Association of Chromosome Translocation Rate with Low Dose Occupational Radiation Exposures in U.S. Radiologic Technologists

, 2014
Chromosome translocations are a well-recognized biological marker of radiation exposure and cancer risk. However, there is uncertainty about the lowest dose at which excess translocations can be detected, and whether there is temporal decay of induced ...
Simon, Steven L, Linet, Martha S, Doi, Kazataka, Doody, Michele M, Tucker, James D, Kampa, Diane M, Sigurdson, Alice J, Miller, Jeremy S, Lee, Terrence, Bhatti, Parveen, Kwon, Deukwoo, Preston, Dale L, Little, Mark P   +12 more
core   +1 more source