Results 281 to 290 of about 1,339,184 (328)

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

open access: yesAdvanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen   +30 more
wiley   +1 more source

First evidence of a biomarker-based dose-response relationship in chronic pain using physiological closed-loop spinal cord stimulation. [PDF]

open access: yesReg Anesth Pain Med
Muller L   +6 more
europepmc   +1 more source

Dose-response relationships for carcinogens

Toxicology Letters, 1995
Biotransformation of chemical carcinogens involves both metabolic activation and detoxication. The molecular dose present on DNA as adducts represents a balance between these two pathways (formation) and DNA repair. All of these are enzymatic processes subject to saturation. When none of the pathways is saturated, linear molecular dosimetry is expected,
J A, Swenberg   +3 more
openaire   +2 more sources

Dose–Response Relationship

2014
Drugs act either by receptor or non-receptor-mediated mechanism. A receptor is usually a macromolecule of a cell with which an endogenous substance or a drug interacts (through specific recognition of binding domain) and elicits its effect (through transduction of signal into response).
openaire   +2 more sources

Home - About - Disclaimer - Privacy