Results 281 to 290 of about 1,339,184 (328)
Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen +30 more
wiley +1 more source
Dose-response relationship between Life's Essential 8 score and COPD risk: the NHANES cohort study 2007-2018. [PDF]
Huang Q +5 more
europepmc +1 more source
First evidence of a biomarker-based dose-response relationship in chronic pain using physiological closed-loop spinal cord stimulation. [PDF]
Muller L +6 more
europepmc +1 more source
Exploring the Dose-Response Relationship Between Nature-Based Outdoor Activities, Nature Connectedness and Social Health In Adolescents: A Quasi-Experimental Controlled Study. [PDF]
Choe EY, Lee JY, Zhu S.
europepmc +1 more source
Dose-response relationship between sedentary time and anxiety and the moderating effect of a 10-min walk: a cross-sectional study. [PDF]
Tian Z +5 more
europepmc +1 more source
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Dose-response relationships for carcinogens
Toxicology Letters, 1995Biotransformation of chemical carcinogens involves both metabolic activation and detoxication. The molecular dose present on DNA as adducts represents a balance between these two pathways (formation) and DNA repair. All of these are enzymatic processes subject to saturation. When none of the pathways is saturated, linear molecular dosimetry is expected,
J A, Swenberg +3 more
openaire +2 more sources
2014
Drugs act either by receptor or non-receptor-mediated mechanism. A receptor is usually a macromolecule of a cell with which an endogenous substance or a drug interacts (through specific recognition of binding domain) and elicits its effect (through transduction of signal into response).
openaire +2 more sources
Drugs act either by receptor or non-receptor-mediated mechanism. A receptor is usually a macromolecule of a cell with which an endogenous substance or a drug interacts (through specific recognition of binding domain) and elicits its effect (through transduction of signal into response).
openaire +2 more sources

