Results 291 to 300 of about 1,297,078 (335)
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Dose-response relationships for carcinogens
Toxicology Letters, 1995Biotransformation of chemical carcinogens involves both metabolic activation and detoxication. The molecular dose present on DNA as adducts represents a balance between these two pathways (formation) and DNA repair. All of these are enzymatic processes subject to saturation. When none of the pathways is saturated, linear molecular dosimetry is expected,
James A. Swenberg +3 more
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Dose Response Relationship [PDF]
, 2014 Drugs act either by receptor or non-receptor-mediated mechanism. A receptor is usually a macromolecule of a cell with which an endogenous substance or a drug interacts (through specific recognition of binding domain) and elicits its effect (through transduction of signal into response).
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Dose-Response Relationship of Phototherapy for Hyperbilirubinemia
Pediatrics, 2012BACKGROUND AND OBJECTIVE:Using light-emitting diodes during conventional phototherapy, it is possible to reduce the distance from light source to infant, thus increasing light irradiance. The objective of this study was to search for a “saturation point” (ie, an irradiation level above which there is no further decrease in total serum bilirubin [TsB]).
Vandborg, Pernille Kure +3 more
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The Dose-Response Relationship of Tranexamic Acid
Anesthesiology, 1995Background Prophylactic administration of the antifibrinolytic drug tranexamic acid decreases bleeding and transfusions after cardiac operations. However, the best dose of tranexamic acid for this purpose remains unknown. This study explored the dose-response relationship of tranexamic acid for hemostatic efficacy after cardiac
Michael D. Strong +4 more
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Dose-Response Relationship in Radiation Leukæmia
Nature, 1959A SIGNIFICANT contribution is achieved by Drs. Armitage, Court Brown and Doll in evaluating some models postulated in assessing the leukaemogenic potency of radiations. Along this line, it appears relevant to discuss some possible interpretations of a linear dose-response, observed over a limited range of leukaemia incidence, as evidenced in the study ...
P, ARMITAGE +3 more
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Dose-Response Relationship With Venlafaxine
Journal of Clinical Psychopharmacology, 1996Considerations when selecting a first-line antidepressant agent include the potential for achieving greater response with increasing dosages, thereby allowing greater flexibility in dosing. The efficacy and dose-response of venlafaxine, a novel serotonin and norepinephrine reuptake inhibitor, was evaluated in two placebo-controlled studies.
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Dose-response relationship for trichloroethylene in man
International Archives of Occupational and Environmental Health, 1977Twelve volunteer students were experimentally exposed to 0, 27, 81 or 201 ppm trichloroethylene for 4 hours, and suffered from irritation to mucous membrane of eyes and throat at over 27 ppm trichloroethylene. No headache or physiological responses were reported at 27 ppm; headache occurred at levels over 81 ppm.
Hiroko Nomiyama, Kazuo Nomiyama
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