Results 231 to 240 of about 1,206,776 (294)
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Mathematical Biosciences, 1988
The authors introduce a concept of a time-dependent dose intensity function as a determinant of the therapeutic outcome of chemotherapy in cancer treatment related to tumor size, generalizing a proposal by Hryniak [\textit{W. M. Hryniak} and \textit{M. Bush}, The importance of dose intensity in the chemotherapy of metastatic breast cancer J.
Coldman, Andrew J. +2 more
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The authors introduce a concept of a time-dependent dose intensity function as a determinant of the therapeutic outcome of chemotherapy in cancer treatment related to tumor size, generalizing a proposal by Hryniak [\textit{W. M. Hryniak} and \textit{M. Bush}, The importance of dose intensity in the chemotherapy of metastatic breast cancer J.
Coldman, Andrew J. +2 more
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Dose Intensity in Chemotherapy
Journal of Clinical Oncology, 1985To the Editor: In a recent article, Hryniuk and Bush have established a strong correlation between dose intensity of CMF (cyclophosphamide, methotrexate, 5-fluorouracil) chemotherapy, and the rate of tumor response in patients with metastatic breast cancer.
Katia Tonkin, Ian Tannock
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Retinoid Chemoprevention Timing and Dose Intensity
Cancer Investigation, 1989The concept of chemoprevention is generating increasing attention among oncologists. This article discusses the issue of dose of chemopreventive agents in relation to the stages of tumor development. Vitamin A-deficient animals have an increased susceptibility to cancer development, and epidemiologic studies have shown an inverse relationship between ...
P R, Band, M, Deschamps, L, Israël
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Dose-intensive approaches to ovarian cancer
Current Oncology Reports, 1999Increasing the total dose or the dose intensity of platinum does not improve survival in women with ovarian cancer. High-dose chemotherapy with hematologic support has not been shown to be more effective than standard-dose chemotherapy. Regional dose intensity, through intraperitoneal chemotherapy, may have a role in the treatment of advanced ovarian ...
N, Lambrou, E L, Trimble
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Selecting Drug Combinations Based on Total Equivalent Dose (Dose Intensity)
JNCI Journal of the National Cancer Institute, 1990We describe a mathematical model for selecting cytotoxic drugs and dosages for a combination regimen based on the antitumor activities of the drugs given as single agents and their organ-specific maximum tolerated doses. The regimen defined maximizes an approximate measure of antitumor effect subject to constraints on combined toxicity.
R, Simon, E L, Korn
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The Journal of infusional chemotherapy, 1997
Paclitaxel is effective in the treatment of cancer of the ovary and cancer of the breast, as well as other malignancies. We have analyzed available phase II data in these two diseases, to assess the possibility that paclitaxel dose intensity may be important in the induction of disease response.
E, Reed, R, Bitton, G, Sarosy, E, Kohn
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Paclitaxel is effective in the treatment of cancer of the ovary and cancer of the breast, as well as other malignancies. We have analyzed available phase II data in these two diseases, to assess the possibility that paclitaxel dose intensity may be important in the induction of disease response.
E, Reed, R, Bitton, G, Sarosy, E, Kohn
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Dose intensity and high dose therapy. Two different concepts
Cancer, 1994"Dose response" refers to a direct relationship between the amount of chemotherapy administered and observed degree of antitumor effect. What is often implied by the term is the administration of pulsed, high dose therapy, resulting in very high peak concentrations.
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