Results 91 to 100 of about 3,118,083 (256)
Three steps towards dose optimization for oncology dose finding
, 2023 Traditional dose selection for oncology registration trials typically employs a one- or two-step single maximum tolerated dose (MTD) approach. However, this approach may not be appropriate for molecularly targeted therapy that tends to have toxicity ...
Liu, Qingyang +3 more
core
Applications of Pharmacometrics in Antibody–Drug Conjugate Development
PharmaceuticsAntibody–drug conjugates (ADCs), which integrate a cytotoxic drug known as the payload into a tumor-targeting monoclonal antibody via a linker, have emerged as promising candidates for cancer therapy and are a new avenue for targeted cancer therapy.
Xiaoliang Cheng +3 more
doaj +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Practical considerations for optimal designs in clinical dose finding studies [PDF]
Determining an adequate dose level for a drug and, more broadly, characterizing its dose response relationship, are key objectives in the clinical development of any medicinal drug. If the dose is set too high, safety and tolerability problems are likely
Dette, Holger +2 more
core
Frontiers in ImmunologyIntroductionThe combination of camrelizumab and apatinib represents a promising treatment strategy for patients with advanced hepatocellular carcinoma (aHCC).
Weikun Huang +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Vascular Health and Risk Management, 2022 Abebech Tewabe Gelaye,1 Mohammed Assen Seid,1 Lemlem Daniel Baffa2 1Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Human Nutrition, Institute of Public ...
Gelaye AT, Seid MA, Baffa LD
doaj
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
This repository contains the data, code, figures, and supporting materials associated with the study “Thermal-Dose-Driven Boundary Element Optimization of Microwave Hyperthermia in Multilayer Biological Tissue.” The package supports reproducibility of ...
Mohamed Abdelsabour Fahmy (10769228)
core +1 more source
Advances in pharmacokinetic-pharmacodynamic modeling for anesthesia, 1987–2024: a review
Frontiers in PharmacologyIn the field of individualized anesthesia, pharmacokinetic-pharmacodynamic (PKPD) models are crucial as they assist in determining the appropriate dosage for various patient groups.
Yara Tulbah, Ibrahim Aljamaan
doaj +1 more source