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Methadone at tapered doses for the management of opioid withdrawal
2005Despite widespread use in many countries the evidence of tapered methadone's efficacy in managing opioid withdrawal has not been systematically evaluated.To evaluate the effectiveness of tapered methadone compared with other detoxification treatments and placebo in managing opioid withdrawal on completion of detoxification and relapse rate.We searched:
L, Amato +4 more
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The Journal of Clinical Pharmacology, 1994
The authors compared the outcome of 208 smokers treated with fixed‐dose transdermal nicotine (n = 69), tapered‐dose transdermal nicotine (n = 71), or Buspirone (n = 68). At baseline, there were no significant differences among the three treatment groups with regard to age, gender, educational level, duration of smoking, number of cigarettes smoked per ...
D E, Hilleman +2 more
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The authors compared the outcome of 208 smokers treated with fixed‐dose transdermal nicotine (n = 69), tapered‐dose transdermal nicotine (n = 71), or Buspirone (n = 68). At baseline, there were no significant differences among the three treatment groups with regard to age, gender, educational level, duration of smoking, number of cigarettes smoked per ...
D E, Hilleman +2 more
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Increased Risk of Overdose, Mental Health Crisis with Opioid Dose Tapering
AJN, American Journal of Nursing, 2021According to this study: Among patients prescribed stable, long-term, higher-dose opioid therapy, dose tapering is associated with a significantly increased risk of overdose and mental health crisis.
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Journal of Women's Health, 2012
To determine whether titrating up and tapering down of desvenlafaxine (administered as desvenlafaxine succinate) improves its tolerability in postmenopausal women with vasomotor symptoms (VMS).In the 1-week titration phase, participants received desvenlafaxine 100 mg/d (no titration), desvenlafaxine 50 mg/d, desvenlafaxine 25 mg/d (4 days) then 50 mg/d
J Christopher, Gallagher +5 more
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To determine whether titrating up and tapering down of desvenlafaxine (administered as desvenlafaxine succinate) improves its tolerability in postmenopausal women with vasomotor symptoms (VMS).In the 1-week titration phase, participants received desvenlafaxine 100 mg/d (no titration), desvenlafaxine 50 mg/d, desvenlafaxine 25 mg/d (4 days) then 50 mg/d
J Christopher, Gallagher +5 more
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Evaluation of Stress Dose Hydrocortisone Tapers in Septic Shock
Hospital PharmacyIntroduction: Stress dose hydrocortisone is recommended in septic shock. Discontinuation can lead to withdrawal after prolonged durations of therapy. There is no guidance on the use of steroid tapers. Our objective was to assess prescribing practices and evaluate stress dose hydrocortisone tapers in septic shock.
Hannah Elizabeth Gilchrist +2 more
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In long-term, higher-dose opioid use, dose tapering was linked to overdose and mental health crises
Annals of Internal Medicine, 2022Agnoli A, Xing G, Tancredi DJ, et al. Association of dose tapering with overdose or mental health crisis among patients prescribed long-term opioids. JAMA. 2021;326:411-9. 34342618.
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Opioid-Dependent Patients Require Slow Tapering Of Drug Dose
AJN, American Journal of Nursing, 2019The Food and Drug Administration (FDA) is reminding health care providers that patients receiving long-term opioids for pain could experience significant withdrawal symptoms if the drugs are stopped too abruptly.The FDA recommends a 10% to 25% dose reduction every two to four weeks for opioid-dependent patients.
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Rethinking Opioid Dose Tapering, Prescription Opioid Dependence, and Indications for Buprenorphine
Annals of Internal Medicine, 2019The expanded use of opioids for chronic pain has created a population of patients prescribed long-term opioid therapy at doses that are often above those recommended by the Centers for Disease Cont...
Roger, Chou +2 more
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Int. Journal of Clinical Pharmacology and Therapeutics, 2002
To determine if there is a difference in early relapse rates and adrenal suppression between patients receiving an 8-day course of 40 mg/day prednisolone and those receiving an 8-day tapering course of prednisolone.This was a prospective, randomized, open clinical trial conducted in a tertiary care center.
R S, Karan +4 more
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To determine if there is a difference in early relapse rates and adrenal suppression between patients receiving an 8-day course of 40 mg/day prednisolone and those receiving an 8-day tapering course of prednisolone.This was a prospective, randomized, open clinical trial conducted in a tertiary care center.
R S, Karan +4 more
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Alefacept in combination with tapering doses of cyclosporine in patients with psoriasis
Journal of the American Academy of Dermatology, 2004The systemic agent cyclosporine has inhibitory effects on T-cell activation, which likely account for its efficacy in the treatment of moderate to severe psoriasis. However, the use of cyclosporine is limited because of dose-related toxicities (eg, hypertension, nephrotoxicity), which necessitate routine monitoring of its safety.
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