Results 261 to 270 of about 89,922 (309)
Molecular Cell, 2018 FANCA is a component of the Fanconi anemia (FA) core complex that activates DNA interstrand crosslink repair by monoubiquitination of FANCD2. Here, we report that purified FANCA protein catalyzes bidirectional single-strand annealing (SA) and strand ...
Anaid Benitez +2 more
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Recombination initiated by double-strand breaks
Current Genetics, 1993The HO endonuclease was used to introduce a site-specific double-strand break (DSB) in an interval designed to monitor mitotic recombination. The interval included the trp1 and his3 genes inserted into chromosome III of S. cerevisiae between the CRY1 and MAT loci. Mitotic recombination was monitored in a diploid carrying heteroalleles of trp1 and his3.
C B, McGill +3 more
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Caged Single and Double Strand Breaks
Bioconjugate Chemistry, 1999Ionizing radiation and radiomimetic drugs such as bleomycin, calichieamycin, neocarzinostatin chromophore, and other synthetic agents can produce both single and double strand breaks in DNA. The ability to study the structure-activity relationships of single and double-strand break repair, lethality, and mutagenesis in vivo is complicated by the ...
P, Ordoukhanian, J S, Taylor
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DNA double‐strand breaks in mutagenesis
Environmental and Molecular Mutagenesis, 1993The DNA-double-strand break (dsb) appears to be the major lesion involved in chromosomal aberration formation. It is also very likely that the DNA dsb is the dominant lesion involved in radiation-induced mutagenesis. The dsb has been implicated as the primary lesion responsible for the induction of large deletions and, to a lesser extent, large ...
J W, Phillips, W F, Morgan
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Mechanisms of insertions at a DNA double-strand break
Molecular Cell, 2023Insertions and deletions (indels) are common sources of structural variation, and insertions originating from spontaneous DNA lesions are frequent in cancer. We developed a highly sensitive assay called insertion and deletion sequencing (Indel-seq) to monitor rearrangements in human cells at the TRIM37 acceptor locus that reports indels stemming from ...
Jaewon, Min +10 more
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Coping with DNA double strand breaks
DNA Repair, 2010The repair of DNA double strand breaks (dsb) is important for maintaining the physical and genetic integrity of the genome. Moreover, in humans it is associated with the prevention of diseases such as immune deficiencies and cancer. This review briefly explores the fundamental strategies for repairing dsb, examines how cells maximize the fidelity of ...
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BRCA1: Beyond double-strand break repair
DNA Repair, 2015Since its discovery, the BRCA1 tumor suppressor has been shown to play a role in multiple DNA damage response pathways. Here, we will review the involvement of BRCA1 in base-excision DNA repair and highlight its clinical implications.
Elizabeth, Alli, James M, Ford
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DNA Double Strand Breaks and Chromosomal Aberrations
Cytogenetic and Genome Research, 2010DNA double strand breaks (DSBs) are ultimate lesions for the formation of chromosomal aberrations (CAs). The formation of CAs is dependent on many factors; some of these are discussed in this review. FISH methodologies have uncovered CA types which cannot be seen with the classical staining methods, and thereby widened our understanding of the origin ...
G. Obe, DURANTE, MARCO
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DNA Double-Strand Break Repair Assay
Cold Spring Harbor Protocols, 2017DNA double-strand breaks (DSBs), arising during normal DNA metabolism or following exposure to mutagenic agents such as ionizing radiation can lead to chromosomal rearrangements and genome instability, and are potentially lethal if unrepaired. Therefore, understanding the mechanisms of DSB repair and misrepair, and identifying the factors involved in ...
Chen-Chun, Pai +2 more
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DNA Double Strand Break Induction in Yeast
Radiation Protection Dosimetry, 2002The induction of DNA double strand breaks (DSBs) by accelerated heavy ions was systematically measured in diploid yeast cells. Particles were provided by the accelerators at GSI, Darmstadt, and HMI, Berlin. DNA was separated using pulsed field gel electrophoresis and the intensity of the largest bands used to determine the loss of molecular weight ...
J, Kiefer, R, Egenolf, S E, Ikpeme
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