Results 71 to 80 of about 10,952,065 (350)

Relevance as the Moving Ground of Semiosis

Philosophies, 2022
All levels of semiosis, from the materiality of signs to their contents and the contexts of their application, are structured by a selectivity in human experience and action that foregrounds only a fraction of the situation here and now.
Jan Strassheim
doaj   +1 more source

Graphic Thinking and Digital Processes: Three Built Case Studies of Digital Materiality [PDF]

, 2017
Think strategic link between computer programming; digital modeling; the data; matter and CNC manufacturing in the various stages of the architectural project is key to update our discipline with new technologies.
Castaño Perea, Enrique (Coordinador), Chiarella, Mauro, Echevarría, Ernesto (Coordinador), Martín Pastor, Andrés, Sáez, Nicolás   +4 more
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

ESG-ratings: development trends, international and national practices

π-Economy, 2023
The article reveals the results of the study of key trends in the development of ESG-ratings, taking into account the practices of leading providers and regulatory bodies in the field in the global and national markets.
Babkin Aleksandr, Salimova Tatiana, Soldatova Elena   +2 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Reporting in circles? How public firms navigate ESRS E5 on the circular economy [PDF]

MAB
In 2024, the first annual reports prepared under the CSRD guidelines were published. This study examines how 75 companies listed on the Amsterdam stock exchange report on their performance regarding the circular economy, as framed in ESRS E5, with the ...
Karen Maas, Diane Zandee, Marleen Janssen Groesbeek   +2 more
doaj   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Impact of environmental double materiality on firm valuation: Evidence from the EU

International Review of Economics & Finance
This study examines how environmental reporting influences firm valuation across high-impact EU sectors. We focus on disclosures related to environmental supply chain management, energy efficiency, water efficiency, renewable energy use, and green ...
Pai-Chin Huang, Nawazish Mirza, Muhammad Umar, Alexandra Horobet   +3 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source