Results 91 to 100 of about 1,417,411 (244)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Negation 'presupposition' and metarepresentation: a response to Noel Burton-Roberts [PDF]
, 1999 Metalinguistic negation (MN) is interesting for at least the following two reasons: (a) it is one instance of the much broader, very widespread and various phenomenon of metarepresentational use in linguistic communication, whose semantic and pragmatic ...
Carston, R
core
Ultrasheaves and double negation
, 2004 Moerdijk has introduced a topos of sheaves on a category of filters. Following his suggestion, we prove that its double negation subtopos is the topos of sheaves on the subcategory of ultrafilters—the ultrasheaves.
Awodey, Steve, Eliasson, Jonas,
core +1 more source
Negative constructions in selected Middle English verse texts [PDF]
, 2012 The objective of the present study is to investigate the historical development of negative constructions in ME verse and to provide a descriptive account of it. The central issues analyzed in this thesis are: (1) the usage of the negative adverbs 'ne'
Iyeiri, Yoko
core +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
L’horizon de la logique lemmique
Ebisu: Études Japonaises, 2013 Yamanouchi Tokuryū, developing the thought expressed by Nāgārjuna in his Fundamental Verses of the Middle Way, formalized a logic of the lemma differing from that of the logos, viz. the tetralemma combining the four lemmas: 1. A; 2. Ā (non-A); 3. neither
Nobuo Kioka
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
The Revolution of The Transcendence
Kanz Philosophia: A Journal for Islamic Philosophy and Mysticism, 2011 Contrary to the general and common idea that Islam etymologically means submission, surrendering, servitude or even slavery, this paper tries to prove just the opposite, that Islam is a protest, an opposition and a revolution.
Hassan Hanafi
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source