Results 71 to 80 of about 3,402 (282)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
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NII Technical Report (NII-2004-010E)：On the Semantics of Classical First-Order Logic with Constructive Double Negation [PDF]
, 2004 Constructive negation in intuitionistic logic (called strong negation) can be used to directly represent negative assertion, and for which its semantics is defined in Kripke models by two satisfaction relations.
兼岩, 憲, Kaneiwa, Ken
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
ALETHEIA, DOUBLE NEGATION AND NEGATION
, 2020 . The main result of present paper is that the definition of negation has to be referred to the totality of a theory and at last to what is defined as the organization of a scientific theory; in other words, negation’s definition is of a structural kind,
Drago, Antonino
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ЯВЛЕНИЕ ДВОЙНОГО ОТРИЦАНИЯ В ОСЕТИНСКОМ ЯЗЫКЕ
Sovremennye Issledovaniâ Socialʹnyh Problem, 2015 Определения термина «двойное отрицание». Явление двойного отрицания в различных языковых системах. Двойным отрицанием в осетинском языке принимается сочетание отрицательного местоимения или наречия с отрицательным глаголом, то есть глаголом с ...
Lana Vladimirovna Dzasokhova
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Frontiers in Psychology, 2019 This investigation draws from research on negative polarity item (NPI) illusions in order to explore a new and interesting instance of misalignment observed for grammatical sentences containing two negative markers.
Iria de-Dios-Flores, Iria de-Dios-Flores
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Double-Negation Elimination in Some Propositional Logics
Studia Logica, 2005 This article answers two questions (posed in the literature), each concerning the guaranteed existence of proofs free of double negation. A proof is free of double negation if none of its deduced steps contains a term of the form n(n(t)) for some term t, where n denotes negation.
Michael Beeson, Robert Veroff, Larry Wos
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
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