Results 71 to 80 of about 92,808 (246)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
ЯВЛЕНИЕ ДВОЙНОГО ОТРИЦАНИЯ В ОСЕТИНСКОМ ЯЗЫКЕ
Sovremennye Issledovaniâ Socialʹnyh Problem, 2015 Определения термина «двойное отрицание». Явление двойного отрицания в различных языковых системах. Двойным отрицанием в осетинском языке принимается сочетание отрицательного местоимения или наречия с отрицательным глаголом, то есть глаголом с ...
Lana Vladimirovna Dzasokhova
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Frontiers in Psychology, 2019 This investigation draws from research on negative polarity item (NPI) illusions in order to explore a new and interesting instance of misalignment observed for grammatical sentences containing two negative markers.
Iria de-Dios-Flores, Iria de-Dios-Flores
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Residuated Structures Derived from Commutative Idempotent Semirings
Discussiones Mathematicae - General Algebra and Applications, 2019 Since the reduct of every residuated lattice is a semiring, we can ask under what condition a semiring can be converted into a residuated lattice. It turns out that this is possible if the semiring in question is commutative, idempotent, G-simple and ...
Chajda Ivan, Länger Helmut
doaj +1 more source
Complete Boolean algebras are Bousfield lattices
, 2017 Given a complete Heyting algebra we construct an algebraic tensor triangulated category whose Bousfield lattice is the Booleanization of the given Heyting algebra.
AK Bousfield +9 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Preverbal negative markers in Buli [PDF]
, 2009 This article deals with some aspects of negation in Buli, a Gur language spoken by the Bulsa people in Northern ...
Schwarz, Anne
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source