Results 71 to 80 of about 92,640 (295)
Probabilistic Algorithmic Knowledge [PDF]
, 2005 The framework of algorithmic knowledge assumes that agents use deterministic knowledge algorithms to compute the facts they explicitly know. We extend the framework to allow for randomized knowledge algorithms.
Fagin, R. and J. Y. Halpern (1988) +12 more
core +4 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Negation, 'presupposition' and the semantics/pragmatics distinction [PDF]
, 1998 A cognitive pragmatic approach is taken to some long-standing problem cases of negation, the so-called presupposition denial cases. It is argued that a full account of the processes and levels of representation involved in their interpretation typically ...
Carston, R
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Recapture, Transparency, Negation and a Logic for the Catuskoti [PDF]
, 2019 The recent literature on Nāgārjuna’s catuṣkoṭi centres around Jay Garfield’s (2009) and Graham Priest’s (2010) interpretation. It is an open discussion to what extent their interpretation is an adequate model of the logic for the catuskoti, and the Mūla ...
Kreutz, Adrian
core
THE HERBRAND FUNCTIONAL INTERPRETATION OF THE DOUBLE NEGATION SHIFT [PDF]
The Journal of Symbolic Logic, 2017 AbstractThis paper considers a generalisation of selection functions over an arbitrary strong monad T, as functionals of type $J_R^T X = (X \to R) \to TX$. It is assumed throughout that R is a T-algebra. We show that $J_R^T$ is also a strong monad, and that it embeds into the continuation monad $K_R X = (X \to R) \to R$.
Escardo, M, Oliva, P
openaire +3 more sources
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source