Results 71 to 80 of about 2,249 (265)
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Croatian secondary school students’ errors in forming syntactic negation in English [PDF]
Hum, 2019 The acquisition of negation in the second language has been investigated in numerous studies (Cancino et al., 1975; Meisel, 1997;Fuentes, 2008), however, there are no systematic studies of the acquisition of the English negation by speakers of the ...
Iva Grubišić Ćurić
doaj
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
L’horizon de la logique lemmique
Ebisu: Études Japonaises, 2013 Yamanouchi Tokuryū, developing the thought expressed by Nāgārjuna in his Fundamental Verses of the Middle Way, formalized a logic of the lemma differing from that of the logos, viz. the tetralemma combining the four lemmas: 1. A; 2. Ā (non-A); 3. neither
Nobuo Kioka
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
The Revolution of The Transcendence
Kanz Philosophia: A Journal for Islamic Philosophy and Mysticism, 2011 Contrary to the general and common idea that Islam etymologically means submission, surrendering, servitude or even slavery, this paper tries to prove just the opposite, that Islam is a protest, an opposition and a revolution.
Hassan Hanafi
doaj +1 more source
Some applications of double-negation sheafification [PDF]
Proceedings of the Edinburgh Mathematical Society, 1977 In this note we point out that certain algebraic-topological constructions are particular cases of one construction, namely double-negation sheafification. The principal cases we have in mind are concerned with booleanpowers, completions of boolean algebras, and maximal rings of quotients.We conjecture that several other constructions—particularly ...
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source