Results 61 to 70 of about 214,168 (304)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Causative in Gban

Mandenkan
The paper describes ways of expressing causative semantics in Gban: by lexical means (suppletive pairs and lability), by periphrastic means, and by morphological means: the productive derivational suffix ‑kà with broad causative semantics.
Maksim Fedotov
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Benefactive Verbs in Double Object Contruction (DOC) In English Sentence BENEFACTIVE VERBS IN DOUBLE OBJECT CONSTRUCTION (DOC) IN ENGLISH SENTENCES

, 2020
This study focuses on the syntactic and semantic features of the benefactive verbs in double object construction ...
Jurnal Sosioteknologi Edisi, Nia Kurniasih   +1 more
core  

Research on the ventilation and control method of double-hole complementary construction of long tunnel

Scientific Reports
The realization of two-bore complementary ventilation in construction tunnels is a new challenge. This paper takes two-way four-lane, six-lane and eight-lane tunnel as the research object, and studies the possibility of two-bore complementary ...
Wang Xiaoming, Zhao Yu, Yang Guang, Zhao Xinyu, Liu Dong, Wei Hongliang, Chen Shiqiang, Deng Huan   +7 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Argument structure hierarchies and alternations in causative and double object constructions

Glossa
Many varieties of Arabic display a causative construction that adds a causer to the argument structure of the underlying verb. When this verb is transitive, the causative derivative is ditransitive.
Peter Hallman
doaj   +2 more sources

Theoretical and Empirical Research on Improving the Quality of Higher Vocational College Enterprise Cooperation Based on PDCA Cycle [PDF]

SHS Web of Conferences
The quality of school enterprise cooperation in vocational colleges is one of the important indicators for the quality of teaching practice in vocational colleges.
Zhang Chao
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Analysis of the Double Object Construction from Corpus Study

, 2011
The study of the double object construction (DOC for short) (S+V+N1+N2) has been one of the most heated topics in modern linguistics, and a lot of studies have been made on this language phenomenon.
ZANG, Fuwei, GAO, li
core   +1 more source