Results 71 to 80 of about 663,039 (282)

Focus in Double Object Constructions

Linguistics, 2005
Studies of the English dative alternation during the last three decades have not yet reached an agreement on the proper syntactic analysis of this alternation. The main goal of this article is to show that a study of the information structural properties of certain constructions can provide independent evidence for the adequacy of a particular ...
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Research on the ventilation and control method of double-hole complementary construction of long tunnel

Scientific Reports
The realization of two-bore complementary ventilation in construction tunnels is a new challenge. This paper takes two-way four-lane, six-lane and eight-lane tunnel as the research object, and studies the possibility of two-bore complementary ...
Wang Xiaoming, Zhao Yu, Yang Guang, Zhao Xinyu, Liu Dong, Wei Hongliang, Chen Shiqiang, Deng Huan   +7 more
doaj   +1 more source

The negative evidence hypothesis: the acquisition of the double-object construction by Brazilian-Portuguese English bilinguals

Ilha do Desterro, 2019
This study aims to add to the body of evidence regarding the linguistic structures that seem to be more challenging in L2 acquisition than in L1 acquisition (DeKeyser, 2005; Ellis, 2008; Inagaki, 2001; Slabakova, 2014; Sorace, 2011).
Cândido Oliveira, Alberto Penzin
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Argument structure hierarchies and alternations in causative and double object constructions

Glossa
Many varieties of Arabic display a causative construction that adds a causer to the argument structure of the underlying verb. When this verb is transitive, the causative derivative is ditransitive.
Peter Hallman
doaj   +2 more sources

Theoretical and Empirical Research on Improving the Quality of Higher Vocational College Enterprise Cooperation Based on PDCA Cycle [PDF]

SHS Web of Conferences
The quality of school enterprise cooperation in vocational colleges is one of the important indicators for the quality of teaching practice in vocational colleges.
Zhang Chao
doaj   +1 more source

Case assignment in double object constructions [PDF]

Revista Alicantina de Estudios Ingleses, 1997
This paper analyzes how case assignment takes place in double object constructions in English. It has been claimed in the literature that case could be either structural or inherent. I will provide some evidence showing that this distinction is problematic under certain circumstances. In this sense, I will suggest three different possibilities to unify
openaire   +3 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source