Results 71 to 80 of about 214,168 (304)
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Alternating ditransitives in English: a corpus-based study
, 2009 This thesis is a large-scale investigation of ditransitive constructions and their alternants in English. Typically both constructions involve three participants: participant A transfers an element B to participant C.
Ozon, G.A.
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Input effects on the acquisition of a novel phrasal construction in five year olds [PDF]
, 2012 The present experiments demonstrate that children as young as five years old (M = 5;2) generalize beyond their input on the basis of minimal exposure to a novel argument structure construction.
Wonnacott, Elizabeth +3 more
core +1 more source
Antisymmetry and word order in double object constructions in Zarma
Linguistik Online, 2020 Double Object Construction in Zarma sometimes allows alternations in the order of its internal arguments and the order in some cases may also be fixed.
Waheed Ayisa Jayeola
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Presenting and predicating lower events
, 2013 The effects of different forms of predication have been insightfully (and almost exclusively) studied for 'simple' cases of predication, of which the 'presentational sentence' is maybe the paradigm instantiation.
Brandt, Patrick
core
Selective transfer in the acquisition of english double object constrctions by brazilian learners
Alfa: Revista de Lingüística, 2013 The present study investigates the acquisition of the English double object constructions (GOLDBERG, 1995) by Brazilian learners. We hypothesize that, due to first language (L1) influences, the prepositional ditransitive construction (John gave a book to
Júlia Vidigal Zara +2 more
doaj