Results 91 to 100 of about 213,326 (261)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Comparative Analysis of 500 kV Double-Circuit Transmission Line Electric Field Intensity: Ethiopian Lines Compliance With ICNIRP

IEEE Access
The high-intensity electric fields, which are in the vicinity of power transmission lines, have adverse effects on human and other living beings if they are not within the specified limits.
Tesfaye Nafo Tefera, Gururaj S. Punekar, Kemal Ibrahim Yassin, Milkias Berhanu Tuka   +3 more
doaj   +1 more source

Invariant and invariant statistical equivalence of order β for double set sequences

, 2021
In this paper, for double set sequences, the concepts of asymptotical invariant equivalence and asymptotical invariant statistical equivalence of order β (0 < β ≤ 1) in the Wijsman sense were introduced. Also, some properties of these new equivalence concepts and the relations between them were investigated.
Gülle, Esra, Ulusu, Uğur
openaire   +1 more source

I_2-statistically and I_2-lacunary statistically convergent double set sequences of order η

, 2021
In this study, for double set sequences, as a new approach to the notion of statistical convergence of order η, the notions of Wijsman I_2-statistically convergence of order η, Wijsman strong I_2-Ces`aro summability of order η, Wijsman I_2-lacunary statistically convergence of order η and Wijsman strong I_2-lacunary summability of order η are ...
Ulusu, Uğur, Gülle, Esra
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Asymptotically I_2-Cesàro equivalence of double sequences of sets

, 2016
In this paper, we defined the concepts of asymptotically I_2-Cesàro equivalence and investigate the relationships between the concepts of asymptotically strongly I_2-Cesàro equivalence, asymptotically strongly I_2-lacunary equivalence, asymptotically p-strongly I_2-Cesàro equivalence and asymptotically I_2-statistical equivalence of double sequences of
Ulusu, Uğur, Dündar, Erdinç, Aydın, Bünyamin   +2 more
openaire   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Wijsman I_2-convergence of double sequences of closed sets

, 2014
In this paper, we study the concepts of Wijsman ℐ2, ℐ2∗-convergence and Wijsman ℐ2, ℐ2∗-Cauchy double sequences of sets and investigate the relationships among them.
Nuray, Fatih, Dündar, Erdinç, Ulusu, Uğur   +2 more
openaire   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Wijsman I_2-invariant convergence of double sequences of sets

, 2016
In this paper, we study the concepts of Wijsman invariant convergence, Wijsman invariant statistical convergence, Wijsman I2-invariant convergence (I^σ_W_2), Wijsman I∗_2-invariant convergence (I^∗σ_W_2), Wijsman pstrongly invariant convergence ([W_2Vσ]_p) of double sequence of sets and investigate the relationships among Wijsman invariant convergence,
Tortop, Şükrü, Dündar, Erdinç
openaire   +2 more sources