Results 91 to 100 of about 5,393,020 (341)

Editorial: Altered Expression of Proteins in Cancer: Function and Potential Therapeutic Targets

Frontiers in Oncology, 2022
João Pessoa, Marta Martins, Sandra Casimiro, Carlos Pérez-Plasencia, Varda Shoshan-Barmatz   +4 more
doaj   +1 more source

Arrhythmogenic right ventricular cardiomyopathy: considerations from in silico experiments

Frontiers in Physiology, 2012
Objective: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with remodelling of gap junctions and also, although less well-defined, down-regulation of the fast sodium current. The gap junction remodelling and down-regulation of sodium
Ronald eWilders
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia [PDF]

, 2021
Ming Fu, Ledong Tan, Zefeng Lin, Vincent Chi Hang Lui, Paul Tam, Jonathan R. Lamb, Yan Zhang, Huimin Xia, Ruizhong Zhang, Yan Chen   +9 more
openalex   +1 more source

Transforming Growth Factor-β1 Inhibits Trophoblast Cell Invasion by Inducing Snail-mediated Down-regulation of Vascular Endothelial-cadherin Protein*

Journal of Biological Chemistry, 2013
Background: Transforming growth factor (TGF)-β1 treatment decreases human trophoblast invasion. Results: Smad-dependent up-regulation of Snail mediates TGF-β1-induced down-regulation of VE-cadherin. Conclusion: TGF-β1 decreases human trophoblast invasion
Jung-Chien Cheng, Hsun‐Ming Chang, P. Leung   +2 more
semanticscholar   +1 more source

Osteopontin is down-regulated in hydatidiform mole

Gynecologic Oncology, 2003
Osteopontin (OPN) is a glycoprotein of the extracellular matrix that can bind to different types of receptors including integrins and CD44 receptors. Multiple binding affinity enables OPN to play a role in many physiological and pathological processes. OPN contributes to tumorigenesis in several types of cancers.
Jozsef, Batorfi, Vilmos, Fulop, Jae-Hoon, Kim, David R, Genest, Jozsef, Doszpod, Samuel C, Mok, Ross S, Berkowitz   +6 more
openaire   +3 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Simultaneous regulation of F5H in COMT‐RNAi transgenic switchgrass alters effects of COMT suppression on syringyl lignin biosynthesis

Plant Biotechnology Journal, 2018
Summary Ferulate 5‐hydroxylase (F5H) catalyses the hydroxylation of coniferyl alcohol and coniferaldehyde for the biosynthesis of syringyl (S) lignin in angiosperms.
Zhenying Wu, Nengfei Wang, H. Hisano, Yingping Cao, Fengyan Wu, Wenwen Liu, Y. Bao, Zeng‐Yu Wang, C. Fu   +8 more
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source