Results 101 to 110 of about 1,209,458 (341)
Frontiers in Cellular and Infection Microbiology, 2020 Increasing evidences demonstrate that microorganism and their products protect against bacterial and viral pathogens through various mechanisms including immunomodulation. Streptococcus pneumoniae endopeptidase O (PepO), a pneumococcal virulence protein,
Sijie Li +11 more
doaj +1 more source
The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: MiR-21 and promoter methylation [PDF]
, 2016 Background: PTEN is a tumor suppressor gene which is involved in cellular proliferation, differentiation, and apoptosis. Loss or down-regulation of PTEN plays an important role in human cancers development.
Azadeh, H. +3 more
core +1 more source
Down‐regulation of a kinase defective PKC‐α
FEBS Letters, 1991 A kinase defective mutant of PKC‐α down‐regulates in response to phorboI esters as effectively as the wild‐type protein when introduced into COS‐1 cells. This demonstrates that intramolecular autophosphorylation is not a prerequisite for down‐regulation.
Peter J. Parker, Catherine J. Pears
openaire +3 more sources
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
Effect of CXCR4 on Apoptosis in Osteosarcoma Cells via the PI3K/Akt/NF-κβ Signaling Pathway
Cellular Physiology and Biochemistry, 2018 Background/Aims: Osteosarcoma, the most common primary bone malignancy, arises from primitive transformed cells of mesenchymal origin with the worldwide increasing morbidity and mortality.
Chunming Jiang +8 more
doaj +1 more source
Comparison of photosynthesis and antioxidant performance of several Citrus and Fortunella species under natural chilling stress : S08P24 [PDF]
, 2012 Citrus plants originate from southeastern Asia, in a large area with various climates characterized by a broad range of temperatures. Temperature is assumed to be a key factor in Citrus species adaptation and diversification.
Berti, Liliane +6 more
core
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Down-regulation of myogenin can reverse terminal muscle cell differentiation.
PLoS ONE, 2012 Certain higher vertebrates developed the ability to reverse muscle cell differentiation (dedifferentiation) as an additional mechanism to regenerate muscle. Mammals, on the other hand, show limited ability to reverse muscle cell differentiation. Myogenic
Nikolaos P Mastroyiannopoulos +4 more
doaj +1 more source
Genetic determinants of Nef-mediated CD4 and HLA class I down-regulation differences between HIV-1 subtypes B and C [PDF]
, 2015 BACKGROUND: HIV-1 subtype C Nef sequences have a significantly lower ability overall to down-regulate CD4 and HLA-I than subtype B Nef sequences. Here we investigated whether Nef amino acids differing in frequency between HIV-1 subtypes B and C explain ...
Jaclyn K. Mann +3 more
core +1 more source