Results 11 to 20 of about 1,209,458 (341)

Genetic determinants of HIV-1 subtype C Nef-mediated SERINC3 down-regulation. [PDF]

Virol J
Background Nef-mediated down-regulation of the host restriction factors SERINC3 and SERINC5 significantly enhances HIV-1 infectivity. Natural Nef polymorphisms that affect SERINC3 down-regulation are not as well-characterised as those that affect SERINC5
Samlall N, Reddy T, Ismail N, Brockman MA, Brumme ZL, Ndung'u T, Mann JK.   +6 more
europepmc   +2 more sources

The Impact of Down-Regulation on Obstetrics and Perinatal Outcomes in Singleton Pregnancies After In Vitro Fertilization

Frontiers in Endocrinology, 2021
Backgrounddown-regulation has been widely used in IVF treatment; however, it lacks reports on the impact of down-regulation on obstetrics and perinatal outcomes.
Lei Jin, Jihui Ai, Yu Zheng, Biao Chen, Lan Wang, Xiyuan Dong   +5 more
doaj   +1 more source

Uneven Expression of 20 Human Papillomavirus Genes Associated with Oropharyngeal Carcinoma Ali Adel Dawood

Rambam Maimonides Medical Journal, 2023
Background: Human papillomavirus HPV is considered to be responsible for 95% of virus-related cancers in many organs. Oropharyngeal carcinoma (OC) is distinguished by the transformation of the healthy epithelium into precancerous cells.
Ali Adel Dawood
doaj   +1 more source

Protein Kinase C Life Cycle: Explained Through Systems Biology Approach

Frontiers in Physiology, 2022
Protein kinase C (PKC) enzymes are a family of kinases that mediate signal transduction originating at the cell surface. Most cell membranes can contain functional PKC enzymes.
Naveed Aslam, Farah Alvi, Farah Alvi
doaj   +1 more source

Motivated Down-Regulation of Emotion and Compassion Collapse Revisited

Frontiers in Psychology, 2022
Compassion collapse is a phenomenon where feelings and helping behavior decrease as the number of needy increases. But what are the underlying mechanisms for compassion collapse? Previous research has attempted to pit two explanations: Limitations of the
William Hagman, William Hagman, William Hagman, Gustav Tinghög, Gustav Tinghög, Gustav Tinghög, Stephan Dickert, Stephan Dickert, Paul Slovic, Daniel Västfjäll, Daniel Västfjäll, Daniel Västfjäll   +11 more
doaj   +1 more source

Transcription of toll-like receptors 2, 3, 4 and 9, FoxP3 and Th17 cytokines in a susceptible experimental model of canine Leishmania infantum infection [PDF]

, 2015
Canine leishmaniosis (CanL) due to Leishmania infantum is a chronic zoonotic systemic disease resulting from complex interactions between protozoa and the canine immune system.
A Ives, A Rodriguez, A Rodriguez-Cortes, A Rodriguez-Cortes, A Rodriguez-Cortes, AB Reis, AK House, AK Rai, Alhelí Rodríguez-Cortés, AM Elassad, BL Travi, C Gallego, C Gonzalez-Lombana, C Maia, C Maia, C Riera, CE O'Neil, CF Alves, CR Engwerda, D Menezes-Souza, D Sacks, D Strauss-Ayali, DA Vargas-Inchaustegui, Damer P. Blake, E Bourreau, F Chappuis, FF Tuon, FF Tuon, G Baneth, GA Cezario, GD Melo, GK Katara, GM Santos-Gomes, H Kumar, IR Peters, J Alvar, J Liese, J Moreno, J Sano, JF Flandin, JM Ehrchen, Jordi Alberola, K Ghosh, K Wolk, Karin Allenspach, KL Silva, L Solano-Gallego, L Solano-Gallego, Laia Solano-Gallego, LM Melo, LP Carvalho, MA Almeida, MG Pitta, MJ de Veer, MJ Rica-Capela, MM Figueiredo, MM Figueiredo, MS Nascimento, N Peters, O Courtenay, O Francino, OA Garden, OR Rodrigues, P Desjeux, P Holzmuller, P Kropf, R Kumar, S Lopez Kostka, S Nylen, S Schmitz, S Tiwananthagorn, S Tolouei, SH Wood, Shazia Hosein, T Korn, TM Castilho, VL da Matta, VS Boaventura, VS Raman, Y Belkaid, Yara M. Traub-Csekö, ZK Peng   +81 more
core   +8 more sources

ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals

eLife, 2021
Attachment of ubiquitin (Ub) to cell surface proteins serves as a signal for internalization via clathrin-mediated endocytosis (CME). How ubiquitinated membrane proteins engage the internalization apparatus remains unclear.
Natalya Pashkova, Lokesh Gakhar, Liping Yu, Nicholas J Schnicker, Annabel Y Minard, Stanley Winistorfer, Ivan E Johnson, Robert C Piper   +7 more
doaj   +1 more source

Global analysis of HBV-mediated host proteome and ubiquitylome change in HepG2.2.15 human hepatoblastoma cell line

Cell & Bioscience, 2021
Hepatitis B virus (HBV) infection remains a major health issue worldwide and the leading cause of cirrhosis and hepatocellular carcinoma (HCC). It has been reported previously that HBV invasion can extensively alter transcriptome, the proteome of ...
Sen Yuan, Yousaf Tanzeel, Xuezhang Tian, Dandan Zheng, Naz Wajeeha, Jiaqi Xu, Yujia Ke, Zuopeng Zhang, Xiaojun Peng, Long Lu, Guihong Sun, Deyin Guo, Min Wang   +12 more
doaj   +1 more source

Sorting Nexin 1 Down-Regulation Promotes Colon Tumorigenesis [PDF]

, 2006
PURPOSE: Colon cancer is one of the most common human malignancies, yet studies have only begun to identify the multiple mechanisms that underlie the development of this tumor.
Bianchini, Michele, Campbell, Jean S., Furuya, Momoko H., Guncay, Gabriela D., Holdren, Matthew S., Levy, Estrella Mariel, Liu, Annie, Mordoh, Jose, Nguyen, Anthony P., Nguyen, Lananh N., Parks, W. Tony   +10 more
core   +1 more source

Inhibition of cell proliferation and increased-apoptosis of AGS and SNU-5 cancer cells following small interfering RNA (siRNA)-mediated down-regulation of vascular endothelial growth factor receptor 1 (VEGFR1)

Chronic Diseases Journal, 2018
BACKGROUND: Angiogenesis is vital for development of normal tissue and wound healing; but it play an important role in development of some diseases such as different types of cancer.
Esmaeil Rahimi, Saman Esmaeilnejad, Iman Sadeghi   +2 more
doaj   +1 more source