Results 11 to 20 of about 5,393,020 (341)
ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals
eLife, 2021 Attachment of ubiquitin (Ub) to cell surface proteins serves as a signal for internalization via clathrin-mediated endocytosis (CME). How ubiquitinated membrane proteins engage the internalization apparatus remains unclear.
Natalya Pashkova +7 more
doaj +1 more source
Study on microRNA-9-5p reducing sensitivity of breast cancer cells to doxorubicin through targeting HIC1 [PDF]
Waike lilun yu shijian, 2020 Objective To study the effect of microRNA-9-5p (miR-9-5p) which regulate hypermethylated in cancer 1 (HIC1) in reducing sensitivity of breast cancer MDA-MB-231 cells to doxorubicin (DOX) and the mechanisms.
GAO Hang, ZHAO Feng, WU Yan, PEI Wenjiang, ZHONG Ming, GU Yan, GUO Shanyu, DAI Qiancheng, ZHANG Wei
doaj +1 more source
GAGA Factor Down-regulates Its Own Promoter [PDF]
Journal of Biological Chemistry, 2002 GAGA factor is involved in many nuclear transactions, notably in transcription as an activator in Drosophila. The genomic region corresponding to the Trl promoter has been obtained, and a minimal version of a fully active Trl promoter has been defined using transient transfection assays in S2 cells.
Kosoy, Ana +4 more
openaire +3 more sources
iForest - Biogeosciences and Forestry, 2020 Elevated atmospheric CO2 (eCO2) concentration initially enhances photosynthesis, growth and ecosystem productivity, but the excessive use of nitrogen due to the increased productivity causes uncertainty in long-term ecosystem responses. We exposed Korean
Song WK +8 more
doaj +1 more source
Retrovirology, 2023 Background Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The role of Nef-mediated down-regulation of the host restriction factor SERINC5 in HIV-1 pathogenesis is not well-defined.
Delon Naicker +9 more
doaj +1 more source
Scientia Agricola, 2011 Molecular and metabolic response of plants to a combination of two abiotic stresses is unique and cannot be directly extrapolated from the response of plants to each of the stresses individually.
Violeta Andjelković +1 more
doaj +1 more source
Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation
Cell Death and Differentiation, 2018 p53 is a transcription factor that is implicated in the control of both apoptotic and autophagic cell death. This tumor suppressor elicits both pro-autophagic and anti-autophagic phenotypes depending of its intracellular localization.
T. Goiran +8 more
semanticscholar +1 more source
HSF1 Down-regulates XAF1 through Transcriptional Regulation [PDF]
Journal of Biological Chemistry, 2006 Studies have indicated the role of HSF1 (heat-shock transcription factor 1) in repressing the transcription of some nonheat shock genes. XAF1 (XIAP-associated factor 1) was an inhibitor of apoptosis-interacting protein with the effect of antagonizing the cytoprotective role of XIAP.
Lin, MCM +11 more
openaire +4 more sources
Down-regulation of OGT promotes cisplatin resistance by inducing autophagy in ovarian cancer
Theranostics, 2018 Cisplatin resistance significantly affects the survival rate of patients with ovarian cancer. However, the main mechanism underlying cisplatin resistance in ovarian cancer remains unclear.
Fuxing Zhou +8 more
semanticscholar +1 more source
A novel treatment approach for retinoblastoma by targeting epithelial growth factor receptor expression with a shRNA lentiviral system [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Non-invasive treatment options for retinoblastoma (RB), the most common malignant eye tumor among children, are lacking. Epithelial growth factor receptor (EGFR) accelerates cell proliferation, survival, and invasion of many tumors ...
Yong Chai +6 more
doaj +1 more source