Results 31 to 40 of about 5,393,020 (341)

Dampening of proteomics activity associated with the COVID-19 patients afflicted with asthma based on gene expression pattern

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. It is established that the severity of SARS-CoV-2 infections varies between individuals without underlying health conditions and those with chronic illnesses like asthma.
Ali Adel Dawood
doaj   +1 more source

A new cognitive evaluation battery for Down syndrome and its relevance for clinical trials

Frontiers in Psychology, 2015
The recent prospect of pharmaceutical interventions for cognitive impairment of Down syndrome(DS) has boosted a number of clinical trials in this population.
Susana ede Sola, Susana ede Sola, Rafael ede la Torre, Rafael ede la Torre, Rafael ede la Torre, Gonzalo eSanchez-Benavides, Gonzalo eSanchez-Benavides, Bessy eBenejam, Aida eCuenca-Royo, Aida eCuenca-Royo, Laura edel Hoyo, Joan eRodriguez, Silvina eCatuara-Solarz, Judit eSanchez-Gutiérrez, Ivan eDueñas-Espin, Ivan eDueñas-Espin, Gimena eHernandez, Gimena eHernandez, Jordi ePeña-Casanova, Jordi ePeña-Casanova, Klaus eLangohr, Klaus eLangohr, Sebastià eVidela, Henri eBléhaut, Magi eFarré, Magi eFarré, Mara eDierssen, Mara eDierssen, the eTESDAD Study Group   +28 more
doaj   +1 more source

Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila

Genes & Development, 2016
Methionine generates the methyl donor SAM, which is converted via methylation to SAH, which accumulates during aging. Parkhitko et al. discovered significant life span extension in response to down-regulation of two noncanonical Drosophila homologs of ...
A. Parkhitko, R. Binari, N. Zhang, J. Asara, Fabio Demontis, N. Perrimon   +5 more
semanticscholar   +1 more source

TCR Down-Regulation Controls T Cell Homeostasis [PDF]

The Journal of Immunology, 2009
Abstract TCR and cytokine receptor signaling play key roles in the complex homeostatic mechanisms that maintain a relative stable number of T cells throughout life. Despite the homeostatic mechanisms, a slow decline in naive T cells is typically observed with age.
Boding, Lasse, Bonefeld, Charlotte Menné, Nielsen, Bodil L, Lauritsen, Jens Peter Holst, von Essen, Marina Rode, Hansen, Ann Kathrine, Larsen, Jeppe Madura, Nielsen, Morten Milek, Odum, Niels, Geisler, Carsten   +9 more
openaire   +3 more sources

Power–Pitch Cascade Control-Based Approach for the Up/Down-Regulated Operation of Large Wind Turbines

Applied Sciences
Modern energy needs require controlled and clean power generation. This demands that the wind turbines be integrated into joint generation groups (wind farms) and the power supply passes be managed by the grid.
Adrian Gambier
doaj   +1 more source

SOX7 is down-regulated in lung cancer [PDF]

Journal of Experimental & Clinical Cancer Research, 2013
Abstract Background SOX7 is a transcription factor belonging to the SOX family. Its role in lung cancer is unknown. Methods In this study, whole genomic copy number analysis was performed on a series of non-small cell lung cancer (NSCLC) cell lines and samples from ...
Hayano, T., Garg, M., Yin, D., Sudo, M., Kawamata, N., Shi, S., Chien, W., Ding, L.-W., Leong, G., Mori, S., Xie, D., Tan, P., Koeffler, H.P.   +12 more
openaire   +4 more sources

Nutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard   +10 more
wiley   +1 more source

Basophil FcεRI Expression in Chronic Spontaneous Urticaria: A Potential Immunological Predictor of Response to Omalizumab Therapy

Acta Dermato-Venereologica, 2017
Although the efficacy of omalizumab has been clearly demonstrated in the treatment of chronic spontaneous urticaria (CSU), its mechanism of action, which results in improvement in CSU symptoms, is not entirely understood. This study investigated
Gustavo Deza, Marta Bertolín-Colilla, Ramon M. Pujol, Laia Curto-Barredo, Dulce Soto, Maribel García, Pilar Hernández, Ramon Gimeno, Ana M. Giménez-Arnau   +8 more
doaj   +1 more source

miR-195 targeting MYB activates the PI3K-Akt pathway to regulate the proliferation and malignant metastasis of squamous cell carcinoma of the skin

Pifu-xingbing zhenliaoxue zazhi, 2020
Objective: To investigate the effect and mechanism of miR-195 on the proliferation and malignant metastasis of squamous cell carcinoma of the skin. Methods: The expressions of miR-195 and MYB gene in the epidermoid carcinoma cell line (A431 cells) and ...
Yong-xia DAI, Jie REN, Qing-biao CUI, Lu LI, Xiao-yu CHEN   +4 more
doaj   +1 more source

Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2

International Journal of Molecular Sciences, 2019
Runx2 is essential for osteoblast differentiation and chondrocyte maturation. During osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells, and its expression is upregulated in preosteoblasts, reaches the maximal level in
T. Komori
semanticscholar   +1 more source