Results 71 to 80 of about 1,209,458 (341)

Osteogenic lineage restriction by osteoprogenitors cultured on nanometric grooved surfaces – the role of focal adhesion maturation [PDF]

, 2014
The differentiation of progenitor cells is dependent on more than biochemical signalling. Topographical cues in natural bone extracellular matrix guide cellular differentiation through the formation of focal adhesions, contact guidance, cytoskeletal ...
Bershadsky, Besser, Biggs, Biggs, Biggs, Biggs, Bose, Carol-Anne Smith, Chang, Clark, Dalby, Dalby, Demirkiran, Ge, Gilboa, Grigoriou, Hamilton, Hatten, Hootman, Howe, Jemma N. Roberts, John W. Cassidy, Karuri, Kate White, Lenhert, Manus J. Biggs, Mary Robertson, Matthew J. Dalby, McNamara, Ming-Wei, Navarro, Nikkhah, Reinhart-King, Richard O.C. Oreffo, Salasznyk, Spanjaard, Sundberg-Smith, Tanaka, Tranquillo, Ward, Wiejak, Wojciak-Stothard, Wozniak, Yang, Yang, Zhang, Zimerman   +46 more
core   +1 more source

TCR Down-Regulation Controls T Cell Homeostasis [PDF]

The Journal of Immunology, 2009
Abstract TCR and cytokine receptor signaling play key roles in the complex homeostatic mechanisms that maintain a relative stable number of T cells throughout life. Despite the homeostatic mechanisms, a slow decline in naive T cells is typically observed with age.
Boding, Lasse, Bonefeld, Charlotte Menné, Nielsen, Bodil L, Lauritsen, Jens Peter Holst, von Essen, Marina Rode, Hansen, Ann Kathrine, Larsen, Jeppe Madura, Nielsen, Morten Milek, Odum, Niels, Geisler, Carsten   +9 more
openaire   +4 more sources

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease [PDF]

, 2013
Background: Tobacco is a leading environmental factor in the initiation of respiratory diseases and causes chronic obstructive pulmonary disease (COPD).
Dinh, Q. Thai, Fischer, Axel, Groneberg, Jan David Alexander, Peiser, Christian, Quarcoo, David, Scholz, Frank R., Springer, Jochen   +6 more
core   +1 more source

Down-regulation of GADD45A enhances chemosensitivity in melanoma [PDF]

Scientific Reports, 2018
AbstractMelanoma is a malignant skin cancer with considerable drug resistance. Increased expression of DNA repair genes have been reported in melanoma, and this contributes to chemotherapy resistance. GADD45A is involved in DNA repair, cell cycle arrest and apoptosis in response to physiologic or environmental stresses.
Guoqiang Jiang, Likun Liu, Baoyin Ren, Ping Mao, Jia Wang, Weiling Li, Jing Zhang, Jia Liu, Lin Zhang, Yawei Tang, Lawrence Owusu   +10 more
openaire   +3 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

The Role of Sink Strength and Nitrogen Availability in the Down-Regulation of Photosynthetic Capacity in Field-Grown Nicotiana tabacum L. at Elevated CO2 Concentration

Frontiers in Plant Science, 2017
Down-regulation of photosynthesis is among the most common responses observed in C3 plants grown under elevated atmospheric CO2 concentration ([CO2]).
Ursula M. Ruiz-Vera, Amanda P. De Souza, Stephen P. Long, Stephen P. Long, Stephen P. Long, Donald R. Ort, Donald R. Ort, Donald R. Ort   +7 more
doaj   +1 more source

Diabetic HDL is dysfunctional in stimulating endothelial cell migration and proliferation due to down regulation of SR-BI expression. [PDF]

PLoS ONE, 2012
Diabetic HDL had diminished capacity to stimulate endothelial cell (EC) proliferation, migration, and adhesion to extracellular matrix. The mechanism of such dysfunction is poorly understood and we therefore sought to determine the mechanistic features ...
Bing Pan, Yijing Ma, Hui Ren, Yubin He, Yongyu Wang, Xiaofeng Lv, Donghui Liu, Liang Ji, Baoqi Yu, Yuhui Wang, Y Eugene Chen, Subramaniam Pennathur, Jonathan D Smith, George Liu, Lemin Zheng   +14 more
doaj   +1 more source

Evidence for down-regulation of beta-2-adreno-ceptors in cirrhotic patients with severe ascites [PDF]

, 1986
The density and affinity of beta-2-adrenoceptors on mononuclear cells from peripheral blood were studied in fifteen patients with cirrhosis of different severity and in thirteen controls. There was no significant difference between cirrhotic patients and
AlexanderL. Gerbes, Arthur, Bihari, Boyum, Burghardt, Burroughs, Dieter Jüngst, Fraser, Gustav Paumgartner, Heinsimer, Henriksen, Jenkins, Jörg Remien, Kroeger, Lebrec, Lebrec, Lebrec, Mann, Molinoff, Pugh, Scatchard, Terblanche, Tilman Sauerbruch   +22 more
core   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source