Results 1 to 10 of about 1,249,164 (307)

Cross-syndrome comparison of real-world executive functioning and problem solving using a new problem-solving questionnaire [PDF]

, 2016
Background. Individuals with neurodevelopmental disorders like Williams syndrome and Down syndrome exhibit executive function impairments on experimental tasks (Lanfranchi, Jerman, Dal Pont, Alberti, & Vianello, 2010; Menghini, Addona, Costanzo, & Vicari,
Annette Karmiloff-Smith, Banich, Beck, Best, Bruininks, Bull, Burgess, Burgess, Camp, Capone, Carlson, Carney, Carr, Conners, Costanzo, Dunbar, Dunn, Dykens, Elison, Elliott, Emily K. Farran, Eysenck, Fidler, Field, Gioia, Goodman, Grace-Martin, Greer, Howlin, Joanne S. Camp, Joffe, John, Jurado, Kahney, Lanfranchi, Lee, Leyfer, Leyfer, Lott, McIntosh, Menghini, Mervis, Michael S.C. Thomas, Miyake, Mundy, Nevill, Newell, Pennington, Phillips, Pretz, Raven, Reed, Reitman, Rhodes, Shallice, Shallice, Sheldon, Silverman, Stinton, Stuss, Toplak, Unterrainer, Vandermorris, Woodruff-Borden   +63 more
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Cara Pembelajaran Anak Down Syndrome di Kelas B1 Tk Luar Biasa C Dharma Asih [PDF]

, 2015
This research aimed to describe how learning Down syndrome children in the kindergarten class B1 Exceptional C Dharma Asih Pontianak. The method used is descriptive method with qualitative approach.
Farida, I. (Ida), Marmawi, M. (Marmawi), Yuniarni, D. (Desni)   +2 more
core  

Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome

Cell Reports
Summary: Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is characterized by delayed neurodevelopment, accelerated aging, and increased risk of many co-occurring conditions.
Micah G. Donovan, Angela L. Rachubinski, Keith P. Smith, Paula Araya, Katherine A. Waugh, Belinda Enriquez-Estrada, Eleanor C. Britton, Hannah R. Lyford, Ross E. Granrath, Kyndal A. Schade, Kohl T. Kinning, Neetha Paul Eduthan, Kelly D. Sullivan, Matthew D. Galbraith, Joaquin M. Espinosa   +14 more
doaj   +1 more source

CDK8 Kinase Activity Promotes Glycolysis

Cell Reports, 2017
Summary: Aerobic glycolysis, also known as the Warburg effect, is a hallmark of cancerous tissues. Despite its importance in cancer development, our understanding of mechanisms driving this form of metabolic reprogramming is incomplete. We report here an
Matthew D. Galbraith, Zdenek Andrysik, Ahwan Pandey, Maria Hoh, Elizabeth A. Bonner, Amanda A. Hill, Kelly D. Sullivan, Joaquín M. Espinosa   +7 more
doaj   +1 more source

Severely ill and high-risk COVID-19 patients exhibit increased peripheral circulation of CD62L+ and perforin+ T cells

Frontiers in Immunology, 2023
IntroductionThe emergence of SARS-CoV-2, which causes COVID-19, has led to over 400 million reported cases worldwide. COVID-19 disease ranges from asymptomatic infection to severe disease and may be impacted by individual immune differences.MethodsWe ...
Kelsey E. Lesteberg, Kelsey E. Lesteberg, Paula Araya, Katherine A. Waugh, Katherine A. Waugh, Lakshmi Chauhan, Joaquin M. Espinosa, Joaquin M. Espinosa, J. David Beckham, J. David Beckham, J. David Beckham, J. David Beckham   +11 more
doaj   +1 more source

Perceptions and discourses relating to genetic testing : interviews with people with Down syndrome [PDF]

, 2016
Background: The perceptions of individuals with Down syndrome are conspicuously absent in discussions about the use of prenatal testing. Method: Eight individuals with Down syndrome were interviewed about their views and experience of the topic ...
Barter, B., Hastings, Richard P., Huws, J., Williams, R. R.   +3 more
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Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development

eLife, 2023
Trisomy 21, the genetic cause of Down syndrome, disrupts primary cilia formation and function, in part through elevated Pericentrin, a centrosome protein encoded on chromosome 21.
Cayla E Jewett, Bailey L McCurdy, Eileen T O'Toole, Alexander J Stemm-Wolf, Katherine S Given, Carrie H Lin, Valerie Olsen, Whitney Martin, Laura Reinholdt, Joaquín M Espinosa, Kelly D Sullivan, Wendy B Macklin, Rytis Prekeris, Chad G Pearson   +13 more
doaj   +1 more source

Banning Abortion in Cases of Down Syndrome: Important Lessons for Advances in Genetic Diagnosis [PDF]

, 2018
In December 2017, Ohio passed into law legislation that prohibited physicians from performing abortions if the pregnant woman’s decision was influenced by her belief that the fetus has Down syndrome.
Gostin, Lawrence O., Reingold, Rebecca
core   +1 more source

Region-specific slowing of alpha oscillations associated with visual-perceptual abilities in children born very preterm

Frontiers in Human Neuroscience, 2013
Children born very preterm (≤32 weeks GA) without major intellectual or neurological impairments often express selective deficits in visual-perceptual abilities.
Sam McLeod Doesburg, Alexander eMoiseev, Anthony T Herdman, Urs eRibary, Ruth Eckstein Grunau   +4 more
doaj   +1 more source

Interferon hyperactivity impairs cardiogenesis in Down syndrome via downregulation of canonical Wnt signaling

iScience, 2023
Summary: Congenital heart defects (CHDs) are frequent in children with Down syndrome (DS), caused by trisomy of chromosome 21. However, the underlying mechanisms are poorly understood.
Congwu Chi, Walter E. Knight, Andrew S. Riching, Zhen Zhang, Roubina Tatavosian, Yonghua Zhuang, Radu Moldovan, Angela L. Rachubinski, Dexiang Gao, Hongyan Xu, Joaquin M. Espinosa, Kunhua Song   +11 more
doaj   +1 more source