Results 101 to 110 of about 2,123,623 (331)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effect of grain-sorting waves on alternate bar dynamics: implications of the breakdown of the hydrograph boundary layer [PDF]
Earth Surface DynamicsUnderstanding the morphological responses of gravel-bed rivers to changes in external forces (e.g. water and sediment supply conditions) is a critical concern in river science and engineering.
S. Tanabe, T. Iwasaki
doaj +1 more source
An assessment of post-plague reintroduced native white-clawed crayfish, a Ustropotamobius pallipes, in the Sherston Avon and Tetbury Avon, Wiltshire [PDF]
, 2000 This article reports on the success of reintroducing native crayfish (Austropotamobius pallipes) in the Sherston and Tetbury Avon, following extinction of the population from crayfish plague.
Fraylin, Martin, Spink, Joanna
core
Modeling meander morphodynamics over self-formed heterogeneous floodplains [PDF]
, 2017 This work addresses the signatures embedded in the planform geometry of meandering rivers consequent to the formation of floodplain heterogeneities as the river bends migrate.
Browlie W. R. +10 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Aquatic Insect Colonization and Substrate Changes in a Relocated Stream Segment [PDF]
, 2017 A section of Bear Creek in northwestern Wisconsin was relocated to accommodate new highway construction. The 850-m section of the stream was shortened to 650 m and fashioned with five broad bends and a uniform width and depth. Sandy substrate and lack of
Narf, Richard P
core +2 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
T lymphocytes migrate upstream after completing the leukocyte adhesion cascade
Cell Adhesion & Migration, 2019 The leukocyte adhesion cascade is of critical importance for both the maintenance of immune homeostasis and the ability of immune cells to perform effector functions.
Nicholas R. Anderson +2 more
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer. [PDF]
, 2016 Prostate carcinogenesis involves alterations in several signaling pathways, the most prominent being the PI3K/AKT pathway. This pathway is constitutively active and drives prostate cancer (PCa) progression to advanced metastatic disease. PTEN, a critical
Chowdhary, Harshika +19 more
core +2 more sources