Results 81 to 90 of about 232,209 (289)
Biodiversity of macrozoobenthos in a large river, the Austrian Danube, including quantitative studies in a free-flowing stretch below Vienna: a short review [PDF]
, 2005 The Danube is ca. 2850 km in length and is the second largest river in Europe. The Austrian part of the Danube falls 156 metres in altitude over its 351 km length and, since the early 1950s, the river has been developed into a power-generating waterway ...
Fesl, Christian, Humpesch, Uwe
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Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Ecological IndicatorsIt is widely recognized that climate change and human activities can alter the flow regimes and thus the fish habitats. Limited research has integrated fish habitats with swimming ability and ecological preferences of fish at various life stages to ...
Yiming Zhang, Wensheng Wang, Siyi Yu
doaj +1 more source
Scientific Reports, 2017 Information on the spawning migration, spawning ecology and life history of tropical eels in the Indo-Pacific region is very limited. The physiological and morphological characteristics of tropical freshwater eels, Anguilla bicolor bicolor and A ...
T. Arai, S. R. Abdul Kadir
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Prospective applications of microRNAs in oral cancer
Oncology Letters, 2019 MicroRNAs (miRNAs) are non-coding RNA molecules that are generally encoded by endogenous genes and exert suppressive effects on post-transcriptional regulation of their target genes by translation repression or degradation of mRNA.
Chuan Fang, Ya-dong Li
semanticscholar +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Quantification of channel planform change on the lower Rangitikei River, New Zealand, 1949-2007: response to management? [PDF]
, 2010 The Rangitikei River, a large gravel‐bed wandering river located in the North Island of New Zealand, has outstanding scenic characteristics, recreational, fisheries and wildlife habitat features.
Fuller, Ian C, Richardson, Jane M.
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