Results 11 to 20 of about 63,987 (250)

Resveratrol activation of SIRT1/MFN2 can improve mitochondria function, alleviating doxorubicin‐induced myocardial injury [PDF]

Cancer Innovation, 2023
Background Doxorubicin is a widely used cytotoxic chemotherapy agent for treating different malignancies. However, its use is associated with dose‐dependent cardiotoxicity, causing irreversible myocardial damage and significantly reducing the patient's ...
Qingling Zhang, Yunpeng Zhang, Bingxin Xie, Daiqi Liu, Yueying Wang, Zandong Zhou, Yue Zhang, Emma King, Gary Tse, Tong Liu   +9 more
doaj   +2 more sources

Notch signaling pathway mediates Doxorubicin-driven apoptosis in cancers

Cancer Management and Research, 2018
Zixin Huang,1,* Shuibin Lin,2,* Chongde Long,1 Xin Zhou,1 Yuting Fan,1 Xielan Kuang,1,3 Jia He,1 Jie Ning,1 Han Zhang,1 Qingjiong Zhang,1 Huangxuan Shen1,3 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University ...
Huang Z, Lin S, Long C, Zhou X, Fan Y, Kuang X, He J, Ning J, Zhang H, Zhang Q, Shen H   +10 more
doaj   +1 more source

Dapagliflozin May Protect Against Doxorubicin-Induced Cardiotoxicity

Anatolian Journal of Cardiology, 2023
Background: Doxorubicin is a widely used agent in the treatment of cancer, but the cardiotoxicity associated with this drug limits its potential for use.
Sebahat Ulusan, Kanat Gülle, Ahmet Peynirci, Murat Sevimli, Adnan Karaibrahimoglu, Mevlüt Serdar Kuyumcu   +5 more
doaj   +1 more source

Exercise Training Preserves Myocardial Strain and Improves Exercise Tolerance in Doxorubicin-Induced Cardiotoxicity

Frontiers in Cardiovascular Medicine, 2021
Doxorubicin causes cardiotoxicity and exercise intolerance. Pre-conditioning exercise training seems to prevent doxorubicin-induced cardiac damage.
Igor L. Gomes-Santos, Camila P. Jordão, Clevia S. Passos, Patricia C. Brum, Edilamar M. Oliveira, Roger Chammas, Anamaria A. Camargo, Carlos E. Negrão, Carlos E. Negrão   +8 more
doaj   +1 more source

IFN-γ/Doxorubicin Complex Nanoparticles for Enhancing Therapy in the Context of Human Ovarian Carcinoma

Frontiers in Materials, 2022
The cytokine interferon gamma (IFN-γ) and doxorubicin mono-therapy has been approved by the Food and Drug Administration (FDA) for the treatment of tumors.
Rongyuan Yi, Wanwan Lv, Shan Zheng, Ningyu Zhang, Yuheng Zhang, Kai Yang, Tuo Huang, Yanning Yang, Hui Chu, Jian Chen   +9 more
doaj   +1 more source

Diosmin Alleviates Doxorubicin-Induced Liver Injury via Modulation of Oxidative Stress-Mediated Hepatic Inflammation and Apoptosis via NfkB and MAPK Pathway: A Preclinical Study

Antioxidants, 2021
Hepatotoxicity caused by chemotherapeutic drugs (e.g., doxorubicin) is of critical concern in cancer therapy. This study focused on investigating the modulatory effects of diosmin against doxorubicin-induced hepatotoxicity in Male Wistar rats.
Abdullah F. AlAsmari, Metab Alharbi, Faleh Alqahtani, Fawaz Alasmari, Mohammed AlSwayyed, Sami I. Alzarea, Ibrahim A. Al-Alallah, Adel Alghamdi, Hassan M. Hakami, Meshal K. Alyousef, Youssef Sari, Nemat Ali   +11 more
doaj   +1 more source

Zymosan A Improved Doxorubicin‐Induced Ventricular Remodeling by Evoking Heightened Cardiac Inflammatory Responses and Healing in Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Doxorubicin‐induced myocardial injury is reflected by the presence of vacuolization in both clinical and animal models. The lack of scar tissue to replace the vacuolizated cardiomyocytes indicates that insufficient cardiac inflammation and ...
Guiwen Xu, Zhujing Hao, Wei Xiao, Ruopeng Tan, Mengyang Yuan, Yunlong Xia, Yang Liu   +6 more
doaj   +1 more source

Doxorubicin Cardiomyopathy [PDF]

Cardiology, 2009
Established doxorubicin cardiomyopathy is a lethal disease. When congestive heart failure develops, mortality is approximately 50%. Extensive research has been done to understand the mechanism and pathophysiology of doxorubicin cardiomyopathy, and considerable knowledge and experience has been gained.
Kanu, Chatterjee, Jianqing, Zhang, Norman, Honbo, Joel S, Karliner   +3 more
openaire   +2 more sources

Repeated Remote Ischemic Conditioning Reduces Doxorubicin-Induced Cardiotoxicity

JACC. CardioOncology, 2020
Objectives: This study investigated the cardioprotective effect of repeated remote ischemic preconditioning (rRIC) on doxorubicin-induced cardiotoxicity in mice.
Quan He, PhD, Fangfei Wang, MD, Thomas D. Ryan, PhD, MD, Meghana Chalasani, BS, Andrew N. Redington, MD   +4 more
doaj   +1 more source

Royal Jelly Alleviates Side Effects of Doxorubicin on Male Reproductive System: A Mouse Model Simulated Human Chemotherapy Cycles [PDF]

Research Journal of Pharmacognosy, 2022
Background and objectives: Doxorubicin, an effective anticancer agent, might impair the function of testicular tissue and lead to infertility. Royal jelly can heal male infertility because of its antioxidant activities.
Mansour Safaei Pourzamani, Shahrbanoo Oryan, Parichehr Yaghmaei, Cyrus Jalili, Ali Ghanbari*   +4 more
doaj   +1 more source