Results 11 to 20 of about 218,870 (301)

Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor. [PDF]

PLoS ONE, 2013
Doxorubicin is one of the most effective anti-cancer agents. However, its use is associated with adverse cardiac effects, including cardiomyopathy and progressive heart failure.
Mayel Gharanei, Afthab Hussain, Omar Janneh, Helen Maddock   +3 more
doaj   +3 more sources

Resveratrol activation of SIRT1/MFN2 can improve mitochondria function, alleviating doxorubicin‐induced myocardial injury [PDF]

Cancer Innovation, 2023
Background Doxorubicin is a widely used cytotoxic chemotherapy agent for treating different malignancies. However, its use is associated with dose‐dependent cardiotoxicity, causing irreversible myocardial damage and significantly reducing the patient's ...
Qingling Zhang, Yunpeng Zhang, Bingxin Xie, Daiqi Liu, Yueying Wang, Zandong Zhou, Yue Zhang, Emma King, Gary Tse, Tong Liu   +9 more
doaj   +2 more sources

Doxorubicin-mediated radiosensitivity in multicellular spheroids from a lung cancer cell line is enhanced by composite micelle encapsulation

International Journal of Nanomedicine, 2012
Wen-Hong Xu,1 Min Han,2 Qi Dong,3 Zhi-Xuan Fu,3 Yuan-Yuan Diao,2 Hai Liu,3 Jing Xu,3 Hong-Liang Jiang,4 Su-Zhan Zhang,3 Shu Zheng,3 Jian-Qing Gao,2 Qi-Chun Wei11Department of Radiation Oncology, The Second Affiliated Hospital, School of Medicine ...
Xu WH, Han M, Dong Q, Fu ZX, Diao YY, Liu H, Xu J, Jiang HL, Zhang SZ, Zheng S, Gao JQ, Wei QC   +11 more
doaj   +1 more source

Notch signaling pathway mediates Doxorubicin-driven apoptosis in cancers

Cancer Management and Research, 2018
Zixin Huang,1,* Shuibin Lin,2,* Chongde Long,1 Xin Zhou,1 Yuting Fan,1 Xielan Kuang,1,3 Jia He,1 Jie Ning,1 Han Zhang,1 Qingjiong Zhang,1 Huangxuan Shen1,3 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University ...
Huang Z, Lin S, Long C, Zhou X, Fan Y, Kuang X, He J, Ning J, Zhang H, Zhang Q, Shen H   +10 more
doaj   +1 more source

PEGylated Liposomal Doxorubicin Rechallenge following Doxorubicin-induced Pancreatitis

Current Problems in Cancer: Case Reports, 2020
Drug induced pancreatitis is rare and establishing the exact causal relationship is challenging. Here, we discuss the management of a 60 year-old female patient with stage 3a breast cancer who developed doxorubicin induced pancreatitis 3 days after her ...
Luke Ardolino, Eugene Moylan
doaj   +1 more source

Overexpressed SIRT6 ameliorates doxorubicin-induced cardiotoxicity and potentiates the therapeutic efficacy through metabolic remodeling

Acta Pharmaceutica Sinica B, 2023
Since the utilization of anthracyclines in cancer therapy, severe cardiotoxicity has become a major obstacle. The major challenge in treating cancer patients with anthracyclines is minimizing cardiotoxicity without compromising antitumor efficacy. Herein,
Kezheng Peng, Chenye Zeng, Yuqi Gao, Binliang Liu, Liyuan Li, Kang Xu, Yuemiao Yin, Ying Qiu, Mingkui Zhang, Fei Ma, Zhao Wang   +10 more
doaj   +1 more source

Lipid Emulsion Inhibits the Late Apoptosis/Cardiotoxicity Induced by Doxorubicin in Rat Cardiomyoblasts

Cells, 2018
This study aimed to examine the effect of lipid emulsion on the cardiotoxicity induced by doxorubicin in H9c2 rat cardiomyoblasts and elucidates the associated cellular mechanism.
Raghavendra Baregundi Subbarao, Seong-Ho Ok, Soo Hee Lee, Dawon Kang, Eun-Jin Kim, Ji-Yoon Kim, Ju-Tae Sohn   +6 more
doaj   +1 more source

Randomized phase II study of the PDGFRα antibody olaratumab plus liposomal doxorubicin versus liposomal doxorubicin alone in patients with platinum-refractory or platinum-resistant advanced ovarian cancer

BMC Cancer, 2018
Background Olaratumab is a platelet-derived growth factor receptor-α (PDGFRα)-targeting monoclonal antibody blocking PDGFRα signaling. PDGFRα expression is associated with a more aggressive phenotype and poor ovarian cancer outcomes.
William P. McGuire, Richard T. Penson, Martin Gore, Antonio Casado Herraez, Patrick Peterson, Ashwin Shahir, Robert Ilaria   +6 more
doaj   +1 more source

Exosomal Doxorubicin Reduces the Cardiac Toxicity of Doxorubicin

Nanomedicine, 2015
To test the efficacy and toxicity of exosomal doxorubicin (exoDOX) compared with free doxorubicin.The cytotoxic effects of exoDOX were tested in vitro and in nude mice by measuring the tumor volume. The toxic effects were evaluated by measuring the bodyweight and through histopathologic analyses.
TOFFOLI, GIUSEPPE, Hadla, Mohamad, Corona, Giuseppe, Caligiuri, Isabella, PALAZZOLO, STEFANO, SEMERARO, SABRINA, GAMINI, AMELIA, Canzonieri, Vincenzo, Rizzolio, Flavio   +8 more
openaire   +3 more sources

miR-200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression. [PDF]

, 2012
Acquired resistance to classical chemotherapeutics is a major obstacle in cancer treatment. Doxorubicin is frequently used in breast cancer therapy either as single-agent or in combination with other drugs like docetaxel and cyclophosphamide.
Oak, Prajakta S., Prajakta S. Oak (115995), Florian Kopp, Andreas Roidl, Kopp, Florian, Roidl, Andreas, Prajakta S Oak, Florian Kopp (115988), Ernst Wagner (60760), Andreas Roidl (116002), Wagner, Ernst, Ernst Wagner   +11 more
core   +1 more source