Results 31 to 40 of about 218,870 (301)

Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency.

PLoS ONE, 2019
Doxorubicin is a chemotherapeutic agent that is commonly used to treat a broad range of cancers. However, significant cardiotoxicity, associated with prolonged exposure to doxorubicin, limits its continued therapeutic use.
Christina Schindler, Andie Collinson, Carl Matthews, Amy Pointon, Lesley Jenkinson, Ralph R Minter, Tristan J Vaughan, Natalie J Tigue   +7 more
doaj   +1 more source

TP53 alteration determines the combinational cytotoxic effect of doxorubicin and an antioxidant NAC

Tumor Biology, 2017
The anticancer effect of doxorubicin is closely related to the generation of reactive oxygen species. On the contrary, doxorubicin-induced reactive oxygen species induces heart failure, a critical side effect of doxorubicin.
Yun Sun Lee, Young Joon Choi, JeeYun Lee, Da Mi Shim, Woong-Yang Park, Sung Wook Seo   +5 more
doaj   +1 more source

Platelet-rich plasma inhibits Adriamycin-induced inflammation via blocking the NF-κB pathway in articular chondrocytes

Molecular Medicine, 2021
Background Previous studies showed that doxorubicin could lead to osteoarthritis (OA) by inducing chondrocyte inflammation and apoptosis. Besides, it is reported that platelet-rich plasma (PRP) could suppress the activation of inflammatory NF-κB ...
Haijun Zhao, Weijie Zhu, Wude Mao, Chengkai Shen   +3 more
doaj   +1 more source

Role of aldo-keto reductases and other doxorubicin pharmacokinetic genes in doxorubicin resistance, DNA binding, and subcellular localization

BMC Cancer, 2012
Background Since proteins involved in chemotherapy drug pharmacokinetics and pharmacodynamics have a strong impact on the uptake, metabolism, and efflux of such drugs, they likely play critical roles in resistance to chemotherapy drugs in cancer patients.
Heibein Allan D, Guo Baoqing, Sprowl Jason A, MacLean David A, Parissenti Amadeo M   +4 more
doaj   +1 more source

Electrochemical Behaviour of Doxorubicin Encapsulated in Apoferritin

International Journal of Electrochemical Science, 2013
A voltammetric detection of doxorubicin and encapsulated doxorubicin in apoferritin structure at a carbon paste electrode is the main aim of this study. The samples were measured by differential pulse voltammetry in phosphate buffer (pH 5.5).
Katerina Tmejova, David Hynek, Pavel Kopel, Simona Dostalova, Kristyna Smerkova, Maja Stanisavljevic, Hoai Viet Nguyen, Lukas Nejdl, Marketa Vaculovicova, Sona Krizkova, Rene Kizek, Vojtech Adam   +11 more
doaj   +1 more source

Efficient chemotherapy of rat glioblastoma using Doxorubicin-loaded PLGA nanoparticles with different stabilizers

, 2011
Background: Chemotherapy of glioblastoma is largely ineffective as the blood-brain barrier (BBB) prevents entry of most anticancer agents into the brain.
Markus Glatzel, Kreuter, Jörg (Prof. Dr.), Christian Bernreuther, Olga Maksimenko, Maksimenko, Olga, Khalansky, Alexander S., Jörg Kreuter, Wohlfart, Stefanie, Gelperina, Svetlana, Svetlana Gelperina, Bernreuther, Christian, Stefanie Wohlfart, Alexander S Khalansky, Glatzel, Markus, Alexander S. Khalansky   +14 more
core   +1 more source

Potential Roles of Melatonin in Doxorubicin-Induced Cardiotoxicity: From Cellular Mechanisms to Clinical Application

Pharmaceutics, 2023
Doxorubicin is a potent chemotherapeutic drug; however, its clinical application has been limited due to its cardiotoxicity. One of the major mechanisms of doxorubicin-induced cardiotoxicity is the induction of oxidative stress.
Tanawat Attachaipanich, Siriporn C. Chattipakorn, Nipon Chattipakorn   +2 more
doaj   +1 more source

Temozolomid und pegyliertes liposomales Doxorubicin in Kombination mit Strahlentherapie in der Ersttherapie von Patienten mit Glioblastom WHO Grad IV – eine Phase I/II – Studie (RNOP – 09)

, 2011
Hintergrund: Die EORTC26981/NCIC-CE.3-Studie hatte 2005 zur Etablierung eines neuen Standard-Therapieregimes für das Glioblastom geführt. Obwohl sich Temozolomid hierbei als wirksames Agens gezeigt hatte, bleibt die Prognose für diese Entität sehr ...
Schmid, Christina
core   +1 more source

Comparative cardiac toxicity of anthracyclines in vitro and in vivo in the mouse. [PDF]

PLoS ONE, 2013
The antineoplastic efficacy of anthracyclines is limited by their cardiac toxicity. In this study, we evaluated the toxicity of doxorubicin, non-pegylated liposomal-delivered doxorubicin, and epirubicin in HL-1 adult cardiomyocytes in culture as well as ...
Stefano Toldo, Rachel W Goehe, Marzia Lotrionte, Eleonora Mezzaroma, Evan T Sumner, Giuseppe G L Biondi-Zoccai, Ignacio M Seropian, Benjamin W Van Tassell, Francesco Loperfido, Giovanni Palazzoni, Norbert F Voelkel, Antonio Abbate, David A Gewirtz   +12 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source