Results 31 to 40 of about 176,716 (160)

Doxorubicin Caused Apoptosis of Mesenchymal Stem Cells via p38, JNK and p53 Pathway

Cellular Physiology and Biochemistry, 2013
Background/Aims: Doxorubicin is a widely used chemotherapeutic agent, but its clinical use is restricted because of a high risk of cardiotoxicity. Bone marrow-derived mesenchymal stem cells (BMSCs) may repair ischaemically damaged myocardium through ...
Fan Yang, Hongyang Chen, Yanju Liu, Kun Yin, Yang Wang, Xingda Li, Guohui Wang, Siyue Wang, Xueying Tan, Chaoqian Xu, Yanjie Lu, Benzhi Cai   +11 more
doaj   +1 more source

Melatonin combination with perindopril alleviated doxorubicin cardiac toxicity in L-NAME hypertensive rats: comparative study with perindopril [PDF]

Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2020
Introduction: Doxorubicin is a highly effective anticancer agent with serious cardiotoxic effects. Hypertension is considered as a major risk factor for doxorubicin cardiotoxicity.
Mona Raafat, Amany Hasanin, Ahmed Badawy, Takwa Salam, Wesam El-Bakly   +4 more
doaj   +1 more source

Ascorbic acid mitigates doxorubicin-induced spleen injury in rats: Histopathological and immunohistochemical insights

Pakistan Journal of Pharmaceutical Sciences
This study assessed the protective potential of ascorbic acid against doxorubicin-induced spleen tissue damage in rats. Twenty-eight male Sprague-Dawley rats were divided into four groups.
Arzu Gezer, Mustafa Ozkaraca, Ebru Karada Sari, Grsel Bedir, Pelin Aydn, Hasan Asker, AM Abd El-Aty   +6 more
doaj   +1 more source

Doxorubicin-mediated radiosensitivity in multicellular spheroids from a lung cancer cell line is enhanced by composite micelle encapsulation

International Journal of Nanomedicine, 2012
Wen-Hong Xu,1 Min Han,2 Qi Dong,3 Zhi-Xuan Fu,3 Yuan-Yuan Diao,2 Hai Liu,3 Jing Xu,3 Hong-Liang Jiang,4 Su-Zhan Zhang,3 Shu Zheng,3 Jian-Qing Gao,2 Qi-Chun Wei11Department of Radiation Oncology, The Second Affiliated Hospital, School of Medicine ...
Xu WH, Han M, Dong Q, Fu ZX, Diao YY, Liu H, Xu J, Jiang HL, Zhang SZ, Zheng S, Gao JQ, Wei QC   +11 more
doaj  

Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor. [PDF]

PLoS ONE, 2013
Doxorubicin is one of the most effective anti-cancer agents. However, its use is associated with adverse cardiac effects, including cardiomyopathy and progressive heart failure.
Mayel Gharanei, Afthab Hussain, Omar Janneh, Helen Maddock   +3 more
doaj   +1 more source

Doxorubicin

Reactions Weekly
Johnson-Arbor K, Douedi S, Patel P.
europepmc   +4 more sources

Engineering Novel Amphiphilic Platinum(IV) Complexes to Co-Deliver Cisplatin and Doxorubicin

Molecules
In this study, we report a novel platinum–doxorubicin conjugate that demonstrates superior therapeutic indices to cisplatin, doxorubicin, or their combination, which are commonly used in cancer treatment.
Wjdan Jogadi, Man B. Kshetri, Suha Alqarni, Arpit Sharma, May Cheline, Md Al Amin, Cynthia Sheets, Angele Nsoure-Engohang, Yao-Rong Zheng   +8 more
doaj   +1 more source

A comparison of poly(methyl methacrylate) and silorane-based cements as carriers for local doxorubicin delivery

Journal of Materials Science: Materials in Medicine
Orthopedic osteosarcomas and metastatic lesions can be difficult to treat with systemically delivered chemotherapy agents alone. Following removal of the primary tumor, implantation of cement to fill the lesion is often done to stabilize weight-bearing ...
Grahmm A. Funk, Elizabeth M. Menuey, Zachary D. Denton, Dalan M. Pittz, Alejandro Parrales, Tomoo Iwakuma, Kathleen V. Kilway, Terence E. McIff   +7 more
doaj   +1 more source

The Protective Effect of Metformin Against Doxorubicin Induced Cardiotoxicity in Rabbits

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2019
Back ground: Doxorubicin is a very effective anticancer therapy of the anthracycline's family used in many pediatric and adult cancers. However, due to severe cardiotoxicity adverse effect, the uses of doxorubicin are limited.
Mohammed Hussein shaty, Inam Sameh Arif, Muthanna I. Al-Ezzi   +2 more
doaj   +1 more source

Hesperidin as a preventive resistance agent in MCF–7 breast cancer cells line resistance to doxorubicin

Asian Pacific Journal of Tropical Biomedicine, 2014
Objective: To evaluate of hesperidin to overcome resistance of doxorubicin in MCF-7 resistant doxorubicin cells (MCF-7/Dox) in cytotoxicity apoptosis and P-glycoprotein (Pgp) expression in combination with doxorubicin.
Rifki Febriansah, Dewi P.P. Dyaningtyas, Sarmoko, Nunuk Aries Nurulita, Edy Meiyanto, Agung Endro Nugroho   +5 more
doaj   +1 more source