Results 51 to 60 of about 218,870 (301)

Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells [PDF]

, 2009
BACKGROUND: Chemoresistance acquisition may influence cancer cell biology. Here, bioinformatics analysis of gene expression data was used to identify chemoresistance-associated changes in neuroblastoma biology.
Tatyana Suhan, Barth, Susanne, Breitling, Rainer,, Cinatl jr., Jindrich,, Doerr, Hans Wilhelm, Breitling Rainer, Michaelis, Martin,, Hans W Doerr, Suhan, Tatyana, Doerr Hans W, Cinatl Jindrich, Cinatl jr., Jindrich, Hinsch, Nora, Doerr, Hans W., Denise Klassert, Cinatl Jaroslav, Bernd Mayer, Nora Hinsch, Barth Susanne, Hinsch Nora, Mayer, Bernd,, Klassert, Denise,, Klassert Denise, Cinatl, Jaroslav, Susanne Barth, Hinsch, N., Doerr, H., Cinatl, Jaroslav,, Mayer, B., Martin Michaelis, Breitling, Rainer, Breitling, R., Mayer Bernd, Cinatl, J., Doerr, Hans W.,, Klassert, Denise, Suhan, Tatyana,, Jindrich Cinatl, Suhan Tatyana, Barth, Susanne,, Michaelis, Martin, Cinatl, Jindrich, Rainer Breitling, Hinsch, Nora,, Barth, S., Suhan, T., Michaelis, M., Mayer, Bernd, Klassert, D., Jaroslav Cinatl, Michaelis Martin   +50 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Doxorubicin-Loaded Hybrid Micelles Based on Carboxyl-Terminated Hyperbranched Polyester Polyol

, 2022
The study of self-assembly processes in polymer solutions is the basis of a modern strategy for creating targeting systems for various substrates. In turn, the use of binary polymer/surfactant systems makes it possible to expand the range of polymers for
Nikolay Ulakhovich, Alexey Nabatov, Marianna Kutyreva, Alexey Nabatov (12245772), Gennadiy Kutyrev (12245775), Gennadiy Kutyrev, Vladimir Evtugyn (4871866), Lenar Valiullin (12245769), Artur Khannanov (5044235), Anastasia Rossova (12245763), Vladimir Evtugyn, Anastasia Rossova, Nikolay Ulakhovich (12245766), Artur Khannanov, Marianna Kutyreva (12245778), Lenar Valiullin   +15 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Engineering Novel Amphiphilic Platinum(IV) Complexes to Co-Deliver Cisplatin and Doxorubicin

Molecules
In this study, we report a novel platinum–doxorubicin conjugate that demonstrates superior therapeutic indices to cisplatin, doxorubicin, or their combination, which are commonly used in cancer treatment.
Wjdan Jogadi, Man B. Kshetri, Suha Alqarni, Arpit Sharma, May Cheline, Md Al Amin, Cynthia Sheets, Angele Nsoure-Engohang, Yao-Rong Zheng   +8 more
doaj   +1 more source

Anti-Inflammatory and Antioxidative Effects of Sumatriptan Against Doxorubicin-Induced Cardiotoxicity in Rat

Acta Medica Iranica, 2021
The clinical use of doxorubicin as a potent chemotherapeutic agent is limited due to its dose-dependent cardiotoxicity. Oxidative stress and inflammatory pathways have a pivotal role in the doxorubicin-induced cardiotoxicity.
Mohammad Sheibani, Hedyeh Faghir-Ghanesefat, Yaser Azizi, Tahmineh Mokhtari, Hasan Yousefi‐Manesh, Roya Sattarzadeh Badkoubeh, Amir Hossein Emami, AhmadReza Dehpour   +7 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Effect of postoperative doxorubicin administration on ischemic wound healing

, 2018
2018-08Some patients undergo postoperative chemotherapy despite showing impaired wound healing after a major surgery. We speculated that postoperative chemotherapy further delays wound healing in these patients. This study aimed to compare the effects of
Toriyama, Kazuhiro, Narita, Yuji, Ebisawa, Katsumi, Hishida, Masashi, Nishida, Yoshihiro, Kamei, Yuzuru, Morishita, Tsuyoshi, Takanari, Keisuke, Yagi, Shunjiro, Osaga, Satoshi   +9 more
core   +1 more source

Morphine enhances doxorubicin-induced cardiotoxicity in the rat [PDF]

, 2014
Interventions to reduce the cardiotoxicity of doxorubicin are clinically relevant. Pharmacological preconditioning mimicking ischemic preconditioning has been demonstrated with morphine and represents an acceptable clinical intervention.
Hole, Lisa Drange, Larsen, Terje H., Terje Hjalmar Larsen, Fredrik Limé, Limé, Fredrik, Jan Schjøtt, Schjøtt, Jan, Kjell Ove Fossan, Fossan, Kjell Ove, Lisa Drange Hole   +9 more
core   +1 more source