Results 41 to 50 of about 176,716 (160)

A Pegylated Liposomal Platform: Pharmacokinetics, Pharmacodynamics, and Toxicity in Mice Using Doxorubicin as a Model Drug

Journal of Pharmacological Sciences, 2004
Aims were to observe pharmacokinetics, pharmacodynamics, and toxicity for constructing a Sino-pegylated liposomal platform. Human hepatocarcinoma cells (Bel7402) and murine hepatocarcinoma cells (H22) were used for the cytotoxicity assay and the in vivo ...
Wan-Liang Lu, Xian-Rong Qi, Qiang Zhang, Rong-Yu Li, Gui-Lin Wang, Rui-Juan Zhang, Shu-Li Wei   +6 more
doaj   +1 more source

A comparison between liposomal and nonliposomal formulations of doxorubicin in the treatment of cancer: An updated review

Archives of Pharmacy Practice, 2016
Cancer remains a major cause of hospitalization and death every year. From time to time, new formulations of anticancer drugs are available in the market and draw the concern of healthcare professionals in terms of the superiority, toxicology, and cost ...
Yik Hoe Ngan, Manish Gupta
doaj   +1 more source

NADPH oxidase 2 mediates cardiac sympathetic denervation and myocyte autophagy, resulting in cardiac atrophy and dysfunction in doxorubicin-induced cardiomyopathy

Scientific Reports
Doxorubicin has been used extensively as a potent anticancer agent, but its clinical use is limited by its cardiotoxicity. However, the underlying mechanisms remain to be fully elucidated.
Yuan Ma, Hui-Ping Zhao, Li-Guo Yang, Lu Li, Ai-Lin Wang, Xiao-Juan Zhang, Ke Wang, Bin Yang, Zong-Feng Zhu, Pei-Jun Zhang, Jia-Pu Wang, Rui-Fang Chi, Bao Li, Fu-Zhong Qin, Zhi-Peng Wang   +14 more
doaj   +1 more source

Memantine, an NMDA Receptor Antagonist, Attenuates Doxorubicin-Induced Cardiac Oxidative Stress and Inflammation in Mouse 4T1 Breast Cancer Model

Breast Cancer: Basic and Clinical Research
Background: Breast cancer is the most common cancer among women, and chemotherapy is a key treatment option. Doxorubicin is frequently used for breast cancer but poses a risk of cardiotoxicity. Recently, memantine, an N-Methyl-D-aspartate antagonist, has
Amirhosein Ghafouri-Asbagh, Koorosh Tabatabaei, Haleh Vaez, Ali Jafarizadeh, Hossein Saeedi, Behrooz Shokouhi, Behzad Baradaran   +6 more
doaj   +1 more source

Targeted delivery of doxorubicin to HER2 positive tumor models

International Journal of Nanomedicine, 2019
Hosna Gomari,1 Mehdi Forouzandeh Moghadam,1 Masoud Soleimani,2 Mahlegha Ghavami,1 Shabanali Khodashenas31Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; 2Department of Hematology, Faculty of ...
Gomari H, Forouzandeh Moghadam M, Soleimani M, Ghavami M, Khodashenas S   +4 more
doaj  

Study the Effect of Crocin on Avoidance Memory and Motor Activity Impairment Induced by Doxorubicin Administration in Adult Male Rats [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2017
Background: A lot of studies indicate that cancer chemotherapy drugs such as doxorubicin results in memory impairment. On the other hand, crocin as the chemical constituent isolated from the Saffron is effective on memory and motor enhancement.
Javad Sohrabi Asadabad, Zohreh Ghotbeddin, Mohammad Reza Tabandeh   +2 more
doaj  

Ameliorative effects of agomelatine against doxorubicin-induced hepatotoxicity

BMC Pharmacology and Toxicology
Drug-induced hepatotoxicity is a significant impediment to the use of doxorubicin, a commonly employed chemotherapeutic agent with established efficacy in cancer treatment.
Hasan Basri Savas, Mehmet Enes Sozen, Gokhan Cuce, Tuba Batur   +3 more
doaj   +1 more source

Cardioprotective Effect of Peperomia pellucida against Doxorubicin-Induced Cardiotoxicity in Wistar Rats via Modulation of Electrocardiographic and Cardiac Biomarkers

Journal of Pharmacopuncture
Objectives: This study assessed the electrocardiographic pattern and cardiac inflammatory response of doxorubicin-induced myocardial injury in Wistar rats treated with Peperomia pellucida ethanol extract.Methods: Female Wistar rats (190-200 g) were ...
Efiok Aniekan Archibong, Justin Atiang Beshel, Idara Asuquo Okon, Glory Aidam Ikum, Stella Chiamaka Anaba, Daniel Udofia Owu   +5 more
doaj   +1 more source

Activation of CISD2 as a protective strategy against doxorubicin-induced cardiotoxicity

Redox Biology
Background: Cardiotoxicity of doxorubicin, a chemotherapy medication, remains the most dangerous side effect. CISD2 plays a critical role during cardiac aging.
Yi-Ju Chou, Chi-Hsiao Yeh, Chian-Feng Chen, Chi-Jen Lo, Jian-Hsin Yang, Wen-Tai Chiu, Cheng-Heng Kao, Tsai-Yu Tzeng, Zhao-Qing Shen, Chien-Yi Tung, Chung-Kuang Lu, Mei-Ling Cheng, Patrick C.H. Hsieh, Shu-Ling Fu, Ting-Fen Tsai   +14 more
doaj   +1 more source

Effect of Eight Weeks of Interval Training Combined with Curcumin Consumption on Cardiac ERK1/2, PI3k and IL-18 Levels in Rats with Breast Cancer Treated with Doxorubicin [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
Introduction: Doxorubicin increases oxidative stress and cardiac damage. ERK1/2, PI3k, and IL-18 seem to play an important role in increasing cardiac damage.
Narges Laghaei, Sedigheh HosseinpourDelavar, Mehran Ghahramani   +2 more
doaj