Results 41 to 50 of about 63,987 (250)

Sulbactam-enhanced cytotoxicity of doxorubicin in breast cancer cells

Cancer Cell International, 2018
Background Multidrug resistance (MDR) is a major obstacle in breast cancer treatment. The predominant mechanism underlying MDR is an increase in the activity of adenosine triphosphate (ATP)-dependent drug efflux transporters.
Shao-hsuan Wen, Shey-chiang Su, Bo-huang Liou, Cheng-hao Lin, Kuan-rong Lee   +4 more
doaj   +1 more source

Platelet-rich plasma inhibits Adriamycin-induced inflammation via blocking the NF-κB pathway in articular chondrocytes

Molecular Medicine, 2021
Background Previous studies showed that doxorubicin could lead to osteoarthritis (OA) by inducing chondrocyte inflammation and apoptosis. Besides, it is reported that platelet-rich plasma (PRP) could suppress the activation of inflammatory NF-κB ...
Haijun Zhao, Weijie Zhu, Wude Mao, Chengkai Shen   +3 more
doaj   +1 more source

Eupatilin-derived compounds enhance antitumor activity and doxorubicin efficacy in triple-negative breast cancer

Frontiers in Oncology
PurposeTriple-negative breast cancer (TNBC) has limited therapeutic options. We evaluated the anticancer activities of the Eupatilin derivatives ONG41008 and ONG41003 and their potential to enhance doxorubicin efficacy.Materials and methodsAnticancer ...
Choong-Jae Lee, Choong-Jae Lee, Jinyoung Park, Yanghee Choi, Sung Hoon Sim, Sun-Young Kong, Sun-Young Kong, Sun-Young Kong   +7 more
doaj   +1 more source

Role of aldo-keto reductases and other doxorubicin pharmacokinetic genes in doxorubicin resistance, DNA binding, and subcellular localization

BMC Cancer, 2012
Background Since proteins involved in chemotherapy drug pharmacokinetics and pharmacodynamics have a strong impact on the uptake, metabolism, and efflux of such drugs, they likely play critical roles in resistance to chemotherapy drugs in cancer patients.
Heibein Allan D, Guo Baoqing, Sprowl Jason A, MacLean David A, Parissenti Amadeo M   +4 more
doaj   +1 more source

Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency.

PLoS ONE, 2019
Doxorubicin is a chemotherapeutic agent that is commonly used to treat a broad range of cancers. However, significant cardiotoxicity, associated with prolonged exposure to doxorubicin, limits its continued therapeutic use.
Christina Schindler, Andie Collinson, Carl Matthews, Amy Pointon, Lesley Jenkinson, Ralph R Minter, Tristan J Vaughan, Natalie J Tigue   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Comparative cardiac toxicity of anthracyclines in vitro and in vivo in the mouse. [PDF]

PLoS ONE, 2013
The antineoplastic efficacy of anthracyclines is limited by their cardiac toxicity. In this study, we evaluated the toxicity of doxorubicin, non-pegylated liposomal-delivered doxorubicin, and epirubicin in HL-1 adult cardiomyocytes in culture as well as ...
Stefano Toldo, Rachel W Goehe, Marzia Lotrionte, Eleonora Mezzaroma, Evan T Sumner, Giuseppe G L Biondi-Zoccai, Ignacio M Seropian, Benjamin W Van Tassell, Francesco Loperfido, Giovanni Palazzoni, Norbert F Voelkel, Antonio Abbate, David A Gewirtz   +12 more
doaj   +1 more source

Potential Roles of Melatonin in Doxorubicin-Induced Cardiotoxicity: From Cellular Mechanisms to Clinical Application

Pharmaceutics, 2023
Doxorubicin is a potent chemotherapeutic drug; however, its clinical application has been limited due to its cardiotoxicity. One of the major mechanisms of doxorubicin-induced cardiotoxicity is the induction of oxidative stress.
Tanawat Attachaipanich, Siriporn C. Chattipakorn, Nipon Chattipakorn   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Electrochemical Behaviour of Doxorubicin Encapsulated in Apoferritin

International Journal of Electrochemical Science, 2013
A voltammetric detection of doxorubicin and encapsulated doxorubicin in apoferritin structure at a carbon paste electrode is the main aim of this study. The samples were measured by differential pulse voltammetry in phosphate buffer (pH 5.5).
Katerina Tmejova, David Hynek, Pavel Kopel, Simona Dostalova, Kristyna Smerkova, Maja Stanisavljevic, Hoai Viet Nguyen, Lukas Nejdl, Marketa Vaculovicova, Sona Krizkova, Rene Kizek, Vojtech Adam   +11 more
doaj   +1 more source