Results 41 to 50 of about 241,371 (303)

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Cardiotoxicity of anthracycline agents for the treatment of cancer: systematic review and meta-analysis of randomised controlled trials [PDF]

, 2010
Background: We conducted a systematic review and meta-analysis to clarify the risk of early and late cardiotoxicity of anthracycline agents in patients treated for breast or ovarian cancer, lymphoma, myeloma or sarcoma.Methods: Randomized controlled ...
Gill Levitt, Smith Lesley A, Cornelius Victoria R, Canney Peter, Levitt, G, Smith, Lesley A., Canney, P, Verrill, Mark, Lesley A Smith, Cornelius, Victoria, Verrill Mark, Plummer, CJ, Verrill, M, Peter Canney, Cornelius, VR, Lesley, A. Smith, Canney, Peter, Plummer, Christopher J., Victoria R Cornelius, Plummer Christopher J, Alison Jones, Smith, LA, Christopher J Plummer, Jones, Alison, Jones Alison, Jones, A, Levitt Gill, Levitt, Gill, Cornelius, Victoria R., Mark Verrill   +29 more
core   +2 more sources

Doxorubicin-Loaded Hybrid Micelles Based on Carboxyl-Terminated Hyperbranched Polyester Polyol

, 2022
The study of self-assembly processes in polymer solutions is the basis of a modern strategy for creating targeting systems for various substrates. In turn, the use of binary polymer/surfactant systems makes it possible to expand the range of polymers for
Nikolay Ulakhovich, Alexey Nabatov, Marianna Kutyreva, Alexey Nabatov (12245772), Gennadiy Kutyrev (12245775), Gennadiy Kutyrev, Vladimir Evtugyn (4871866), Lenar Valiullin (12245769), Artur Khannanov (5044235), Anastasia Rossova (12245763), Vladimir Evtugyn, Anastasia Rossova, Nikolay Ulakhovich (12245766), Artur Khannanov, Marianna Kutyreva (12245778), Lenar Valiullin   +15 more
core   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Biopharmaceutical profiling of cancer targeted gold nanoparticles for doxorubicin delivery

, 2023
reservedThis thesis project is focused on the development of folate-targeted gold nanoparticles for the delivery and controlled release of doxorubicin to the tumour.
TESSARI, ALBERTO
core  

Diazoxide protects against doxorubicin-induced cardiotoxicity in the rat [PDF]

, 2014
Aim: Chemotherapy with doxorubicin is limited by cardiotoxicity. Free radical generation and mitochondrial dysfunction are thought to contribute to doxorubicin-induced cardiac failure.
Hole, Lisa Drange, Larsen, Terje H., Terje Hjalmar Larsen, Fredrik Limé, Limé, Fredrik, Jan Schjøtt, Schjøtt, Jan, Kjell Ove Fossan, Fossan, Kjell Ove, Lisa Drange Hole   +9 more
core   +2 more sources

Exercise Capacity, Physical Activity, Fatigue, and Neurocognitive Function in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess, Gustaf Glavå, Simon Skau, Hans‐Georg Kuhn, Maria Bäck, Marianne Jarfelt   +5 more
wiley   +1 more source

Electrochemical Behaviour of Doxorubicin Encapsulated in Apoferritin

International Journal of Electrochemical Science, 2013
A voltammetric detection of doxorubicin and encapsulated doxorubicin in apoferritin structure at a carbon paste electrode is the main aim of this study. The samples were measured by differential pulse voltammetry in phosphate buffer (pH 5.5).
Katerina Tmejova, David Hynek, Pavel Kopel, Simona Dostalova, Kristyna Smerkova, Maja Stanisavljevic, Hoai Viet Nguyen, Lukas Nejdl, Marketa Vaculovicova, Sona Krizkova, Rene Kizek, Vojtech Adam   +11 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Melatonin combination with perindopril alleviated doxorubicin cardiac toxicity in L-NAME hypertensive rats: comparative study with perindopril [PDF]

Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2020
Introduction: Doxorubicin is a highly effective anticancer agent with serious cardiotoxic effects. Hypertension is considered as a major risk factor for doxorubicin cardiotoxicity.
Mona Raafat, Amany Hasanin, Ahmed Badawy, Takwa Salam, Wesam El-Bakly   +4 more
doaj   +1 more source