Results 71 to 80 of about 397,699 (411)

Repeated Remote Ischemic Conditioning Reduces Doxorubicin-Induced Cardiotoxicity

JACC. CardioOncology, 2020
Objectives: This study investigated the cardioprotective effect of repeated remote ischemic preconditioning (rRIC) on doxorubicin-induced cardiotoxicity in mice.
Quan He, PhD, Fangfei Wang, MD, Thomas D. Ryan, PhD, MD, Meghana Chalasani, BS, Andrew N. Redington, MD   +4 more
doaj  

Proteomic profile of KSR1-regulated signalling in response to genotoxic agents in breast cancer [PDF]

, 2015
Kinase suppressor of Ras 1 (KSR1) has been implicated in tumorigenesis in multiple cancers, including skin, pancreatic and lung carcinomas. However, our recent study revealed a role of KSR1 as a tumour suppressor in breast cancer, the expression of which
A Franceschini, AA Adjei, Arnhild Grothey, B Gyorffy, Cancer Genome Atlas Network, F Yan, F Yan, Georgios Giamas, H Xing, H Zhang, H Zhang, H Zhang, HR Xing, Hua Zhang, I Youlyouz-Marfak, J Cox, J Cox, J Lozano, J Stebbing, J Wielemaker, J Xu, J Zhang, Joao Nunes, Justin Stebbing, JV Olsen, K Kornfeld, L Hannesdottir, M Alcoceba, M Ashburner, M Kim, M Sundaram, M Therrien, M Therrien, Nicos Angelopoulos, NR Michaud, O Tacar, P Tymoszuk, PJ Klutho, R Kaneno, S Datta, S Falcon, S Zhu, Y Cao, Y Pommier, Y Xu, Y Zhang, Y Zhang, Yichen Xu, YJ Jeon   +48 more
core   +3 more sources

A Nanodrug Consisting Of Doxorubicin And Exosome Derived From Mesenchymal Stem Cells For Osteosarcoma Treatment In Vitro

International Journal of Nanomedicine, 2019
Purpose The primary goal of the present study was to develop the nano-drug consisting of doxorubicin and exosome derived from mesenchymal stem cells, and to explore its effect on osteosarcoma in vitro.
Hongxiang Wei, Jinyuan Chen, Sheng-lin Wang, Feihuan Fu, Xia Zhu, Chao-yang Wu, Zhoujie Liu, Guangxian Zhong, Jianhua Lin   +8 more
semanticscholar   +1 more source

Doxorubicin plus dacarbazine, doxorubicin plus ifosfamide, or doxorubicin alone as a first‐line treatment for advanced leiomyosarcoma: A propensity score matching analysis from the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group

Cancer, 2020
The optimal treatment for advanced leiomyosarcoma is still debated. Given histotype‐specific prospective controlled data lacking, this study retrospectively evaluated doxorubicin plus dacarbazine, doxorubicin plus ifosfamide, and doxorubicin alone as ...
L. D’Ambrosio, Nathan Touati, J. Blay, G. Grignani, R. Flippot, A. Czarnecka, S. Piperno-Neumann, J. Martín-Broto, R. Sanfilippo, D. Katz, F. Duffaud, B. Vincenzi, D. Stark, F. Mazzeo, Armin Tuchscherer, C. Chevreau, J. Sherriff, A. Estival, S. Litière, W. Sents, I. Ray-Coquard, F. Tolomeo, A. Le Cesne, P. Rutkowski, S. Stacchiotti, B. Kasper, H. Gelderblom, A. Gronchi   +27 more
semanticscholar   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Comparison of carboplatin and doxorubicin-based chemotherapy protocols in 470 dogs after amputation for treatment of appendicular osteosarcoma. [PDF]

, 2014
BackgroundMany chemotherapy protocols have been reported for treatment of canine appendicular osteosarcoma (OSA), but outcome comparisons in a single population are lacking.ObjectiveTo evaluate the effects of protocol and dose intensity (DI) on treatment
Burton, JH, Lana, SE, Selmic, LE, Thamm, DH, Withrow, SJ   +4 more
core   +2 more sources

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Identifying mechanisms driving the early response of triple negative breast cancer patients to neoadjuvant chemotherapy using a mechanistic model integrating in vitro and in vivo imaging data [PDF]

arXiv, 2022
Neoadjuvant chemotherapy (NAC) is a standard-of-care treatment for locally advanced triple negative breast cancer (TNBC) before surgery. The early assessment of TNBC response to NAC would enable an oncologist to adapt the therapeutic plan of a non-responding patient, thereby improving treatment outcomes while preventing unnecessary toxicities.
arxiv  

Doxorubicin Caused Apoptosis of Mesenchymal Stem Cells via p38, JNK and p53 Pathway

Cellular Physiology and Biochemistry, 2013
Background/Aims: Doxorubicin is a widely used chemotherapeutic agent, but its clinical use is restricted because of a high risk of cardiotoxicity. Bone marrow-derived mesenchymal stem cells (BMSCs) may repair ischaemically damaged myocardium through ...
Fan Yang, Hongyang Chen, Yanju Liu, Kun Yin, Yang Wang, Xingda Li, Guohui Wang, Siyue Wang, Xueying Tan, Chaoqian Xu, Yanjie Lu, Benzhi Cai   +11 more
doaj   +1 more source

Anticancer drug delivery with transferrin targeted polymeric chitosan vesicles [PDF]

, 2004
The study reports the initial biological evaluation of targeted polymeric glycol chitosan vesicles as carrier systems for doxorubicin (Dox). Transferrin (Tf) was covalently bound to the Dox-loaded palmitoylated glycol chitosan (GCP) vesicles using ...
Couet, William, Dufès, Christine, Muller, Jean-Marc, Olivier, Jean-Christophe, Schätzlein, Andreas G., Uchegbu, I.F.   +5 more
core   +1 more source