Results 81 to 90 of about 171,246 (253)

Cardioprotective Effect of Peperomia pellucida against Doxorubicin-Induced Cardiotoxicity in Wistar Rats via Modulation of Electrocardiographic and Cardiac Biomarkers

Journal of Pharmacopuncture
Objectives: This study assessed the electrocardiographic pattern and cardiac inflammatory response of doxorubicin-induced myocardial injury in Wistar rats treated with Peperomia pellucida ethanol extract.Methods: Female Wistar rats (190-200 g) were ...
Efiok Aniekan Archibong, Justin Atiang Beshel, Idara Asuquo Okon, Glory Aidam Ikum, Stella Chiamaka Anaba, Daniel Udofia Owu   +5 more
doaj   +1 more source

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

Near‐Infrared‐Driven Metal–Organic Frameworks‐Based Nanorobots for Controlled Photothermal‐Chemical Therapy Synergistic Induction of Cancer Cell Death

Advanced Robotics Research, EarlyView.
To achieve efficient cancer cell death, a bowl‐shaped PDA@UiO‐66@DOX nanorobot drug‐delivery nanoplatform was developed. Near‐infrared irradiation not only drives the nanorobot to exhibit self‐thermophoretic motion and elevates temperature but also triggers Doxorubicin (DOX) release via hyperthermia, enhancing cancer cells uptake of DOX and thereby ...
Tong Lin, Jie Yang, Yongcheng Li, Yuepeng Cai, Xiaosong Zhou, Ting Chen, Renfeng Dong   +6 more
wiley   +1 more source

Activation of CISD2 as a protective strategy against doxorubicin-induced cardiotoxicity

Redox Biology
Background: Cardiotoxicity of doxorubicin, a chemotherapy medication, remains the most dangerous side effect. CISD2 plays a critical role during cardiac aging.
Yi-Ju Chou, Chi-Hsiao Yeh, Chian-Feng Chen, Chi-Jen Lo, Jian-Hsin Yang, Wen-Tai Chiu, Cheng-Heng Kao, Tsai-Yu Tzeng, Zhao-Qing Shen, Chien-Yi Tung, Chung-Kuang Lu, Mei-Ling Cheng, Patrick C.H. Hsieh, Shu-Ling Fu, Ting-Fen Tsai   +14 more
doaj   +1 more source

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Effect of Eight Weeks of Interval Training Combined with Curcumin Consumption on Cardiac ERK1/2, PI3k and IL-18 Levels in Rats with Breast Cancer Treated with Doxorubicin [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
Introduction: Doxorubicin increases oxidative stress and cardiac damage. ERK1/2, PI3k, and IL-18 seem to play an important role in increasing cardiac damage.
Narges Laghaei, Sedigheh HosseinpourDelavar, Mehran Ghahramani   +2 more
doaj  

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging

Advanced Science, EarlyView.
Cell death is important in both the development and treatment of cancer. In this study, it is demonstrated for the first time that a specific measurement of the transmembrane water exchange rate using magnetic resonance imaging can be used as an early marker of cell death in mammalian cells, in animals and in human patients. Abstract Cell death plays a
Athanasia Kaika, Luca Nagel, Ulrike Höckendorf, Bangwen Xie, Geoffrey J. Topping, Mathias Schillmaier, Irina Beer, Frits H. A. van Heijster, Julian Rauch, Tristan A. Kuder, Sandra Sühnel, Bernd Erber, Christian Lohrmann, Simone Ballke, Thomas Metzler, Katja Steiger, Philipp J. Jost, Natalia P. Ivleva, Philipp Paprottka, Jonathan Nadjiri, Kevin M. Brindle, Wolfgang A. Weber, Franz Schilling   +22 more
wiley   +1 more source