Results 51 to 60 of about 1,771,926 (270)

Accelerate the Highly Efficient Development of mRNA Vaccines Through Advanced Computational Methods

MedComm
mRNA medicine is an emerging therapeutic approach that utilizes messenger RNA to synthesize functional proteins directly within target cells. This technology offers notable advantages including rapid development cycles, diverse therapeutic applications ...
Ruichu Gu, Duanmiao Si, Dingwei Lei, Xiaoxue Xie, Yongge Li, Han Wen   +5 more
doaj   +1 more source

Epidemic processes with immunization

, 2003
We study a model of directed percolation (DP) with immunization, i.e. with different probabilities for the first infection and subsequent infections. The immunization effect leads to an additional non-Markovian term in the corresponding field theoretical
A.S. Perelson, Andrea Jiménez-Dalmaroni, C. Lopez, D. Mollison, F. Schlögl, F. van Wijland, H. Hinrichsen, H. Hinrichsen, H. Hinrichsen, H. Hinrichsen, H.K. Janssen, H.K. Janssen, Haye Hinrichsen, I. Jensen, I. Jensen, I. Jensen, J.-P. Bouchaud, J.F.F. Mendes, J.L. Cardy, J.L. Cardy, J.L. Cardy, K. Oerding, L.H. Tang, M.A. Muñoz, M.A. Muñoz, M.A. Muñoz, P. Fröjdh, P. Grassberger, P. Grassberger, P. Grassberger, P. Grassberger, P. Grassberger, P. Rupp, P.K. Mohanty, R. Dickman, R. Dickman, R.M. Ziff, S.N. Majumdar, S.V. Buldyrev, W. Hwang, Z. Alexandrowicz   +40 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Outcomes and risk score for distal pancreatectomy with celiac axis resection (DP-CAR) : an international multicenter analysis [PDF]

, 2019
Background: Distal pancreatectomy with celiac axis resection (DP-CAR) is a treatment option for selected patients with pancreatic cancer involving the celiac axis.
Adham, Mustapha, Bassi, Claudio, Berrevoet, Frederik, Besselink, Marc G, Boggi, Ugo, Busch, Olivier R, Cesaretti, Manuela, Dalla Valle, Raffaele, Darnis, Benjamin, Del Chiaro, Marco, Diener, Markus K, Dumitrascu, Traian, Friess, Helmut, Fusai, Giuseppe K, Gerritsen, Sarah L, Gruetzmann, Robert, Hackert, Thilo H, Hirono, Seiko, Hogg, Melissa E, Ivanecz, Arpad, Javed, Ammar A, Karayiannakis, Anastasios, Kawai, Manabu, Kleeff, Jorg, Klompmaker, Sjors, Labori, Knut J, Lesurtel, Mickael, Lombardo, Carlo, Lopez-Ben, Santiago, Mabrut, Jean-Yves, Miyazawa, Motoki, Moser, A James, Niesen, Willem, Okada, Ken-ichi, Pardo, Fernando, Perinel, Julie, Peters, Niek A, Popescu, Irinel, Prasad, Raj, Roeyen, Geert, Salvia, Roberto, Sauvanet, Alain, Sturesson, Christian, Teresa Albiol, M, Van Gulik, Thomas M, Van Hilst, Jony, Weiss, Matthew J, Wolfgang, Christopher L, Yamaue, Hiroki, Zeh, Herbert J, Zureikat, Amer H   +50 more
core   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A pre-trained deep potential model for sulfide solid electrolytes with broad coverage and high accuracy

npj Computational Materials
Solid electrolytes with fast ion transport are crucial for solid state lithium metal batteries. Chemical doping has been the most effective strategy for improving ion condictiviy, and atomistic simulation with machine-learning potentials helps optimize ...
Ruoyu Wang, Mingyu Guo, Yuxiang Gao, Xiaoxu Wang, Yuzhi Zhang, Bin Deng, Mengchao Shi, Linfeng Zhang, Zhicheng Zhong   +8 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source