Results 61 to 70 of about 101,617 (297)

Renoprotective Effect of Thai Patients with Type 2 Diabetes Mellitus Treated with SGLT-2 Inhibitors versus DPP-4 Inhibitors: A Real-World Observational Study

Advances in Pharmacological and Pharmaceutical Sciences, 2023
Background. Recently, there is a lack of studies comparing the renoprotective effects of sodium-glucose cotransporter-2 (SGLT-2) inhibitors and dipeptidyl peptidase-4 (DPP-4) inhibitors.
Apichaya Chanawong, Suriyon Uitrakul, Supatcha Incomenoy, Natnicha Poonchuay   +3 more
doaj   +1 more source

Clinical trial simulation methods for estimating the impact of DPP-4 inhibitors on cardiovascular disease [PDF]

, 2015
Charles Andy Schuetz,1 Siew Hwa Ong,2 Matthias Blüher3 1Evidera Inc., Bethesda, MD, USA; 2Novartis Pharma AG, Basel, Switzerland; 3Department of Medicine, University of Leipzig, Leipzig, Germany Introduction: Dipeptidyl peptidase-4 (DPP-4 ...
Ong SH, Blüher M, Schuetz CA
core  

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Use of DPP-4 inhibitors in type 2 diabetes: focus on sitagliptin [PDF]

, 2010
Bo AhrénDepartment of Clinical Sciences, Lund University, Lund, SwedenAbstract: Inhibition of dipeptidyl peptidase-4 (DPP-4) prevents the inactivation of glucagonlike peptide-1 (GLP-1).
Ahren B, Bo Ahrén
core  

Biomimetic Hydrogel System Targeting S100A8 Centered Neuroimmune Crosstalk and Hypoxia Induced Neuronal Injury

Advanced Science, EarlyView.
A biomimetic hydrogel (HPC@Gel) was developed for traumatic brain injury repair by combining oxygen‐carrying hemoglobin nanoparticles and anti‐inflammatory carbon quantum dots within a brain‐like matrix. The system alleviated hypoxia, reduced harmful neuroimmune signaling, protected neurons, supported neural regeneration, and improved neurological and ...
Peng Liu, Xiaoyang Wu, Xiaoyin Liu, Yuyan Wang, Shichao Jiang, Kai Wu, Gaowei Li, Jie Ding, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan, Liangxue Zhou   +12 more
wiley   +1 more source

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, EarlyView.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

Charge Transport in All‐Inorganic CuInSe2 Nanocrystal Transistors: Linking Material Design and Device Performance

Advanced Electronic Materials, EarlyView.
This work explores how colloidal CuInSe2 nanocrystals form functional field‐effect transistors when their native ligands are replaced with short inorganic species that promote charge transport. By systematically adjusting nanocrystal dimensions, surface treatments, film characteristics, and device architecture, the study maps the resulting electronic ...
Nadia Günther, Borja Rodriguez‐Barea, Jasmin L. Herzog, Bjarne E. Stern, Alexandre Ansieau, Angelika Wrzesinska‐Lashkova, Yana Vaynzof, Artur Erbe, Alexander Eychmüller   +8 more
wiley   +1 more source

Non Incretin Effects of DPP-4 Inhibitors: Comparative Study [PDF]

, 2019
Background: Diabetes mellitus is a metabolic syndrome that adversely affects all parts of the body especially the cardiovascular system. Dipeptidyl peptidase-4 (DPP-4) is a multifunctional protein and its inhibition has diverse effects.
A Shabbir Ali Bhatti, M. A.Bhatti, Aliya Shabbir, Abdul Waheed Shehzad   +3 more
core   +2 more sources

Review of the Molecular and Developmental Basis of Myhre Syndrome, Bench Research

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (MS) is a connective‐tissue disorder within the acromelic dysplasia spectrum. It is characterized by congenital craniofacial, skeletal, cutaneous anomalies, respiratory, cardiovascular along with intellectual disability, deafness, and progressive fibrosis.
Camille Viaut, Valerie Cormier‐Daire
wiley   +1 more source

Lipid-lowering effects of DPP-4 inhibitors [PDF]

, 2012
당뇨와 심혈관 질환 및 심장 사망 위험과의 관련성이 대두되면서 당뇨환자들에게 혈중 지질 수치의 조절이 권고되고 있다. 당뇨치료제로 사용되는 약제들도 lipid profile에 영향을 주며 특히 biguanide, thiazolidinedione, dipeptidyl peptidase-4 (DPP-4) inhibitor 계열의 약물들이 이러한 효과를 나타내는 것으로 보고 되었다. 이 중 제 2형 당뇨의 조절을 위해 최근 개발된 약물 군으로 저혈당을
이지연
core