Solvent and thermal stability, and pH kinetics, of proline-specific dipeptidyl peptidase IV-like enzyme from bovine serum [PDF]
, 2007 Proline-specific dipeptidyl peptidase-like (DPP IV; EC 3.4.14.5) activity in bovine serum has attracted little attention despite its ready availability and the paucity of useful proline-cleaving enzymes.
Abbott +43 more
core +1 more source
Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers [PDF]
, 2017 Aryl hydrocarbon receptor (AHR) is the key transcription factor that controls animal development and various adaptive processes. The AHR\u27s target genes are involved in biodegradation of endogenous and exogenous toxins, regulation of immune response ...
Akishina, Angelina A. +11 more
core +1 more source
Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold [PDF]
, 2015 A novel molecular scaffold has been synthesized and its synthesis and incorporation into new analogues of biologically active molecules will be discussed.
Biftu T. +14 more
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Renoprotective Effect of Dipeptidyl Peptidase-4 Inhibitors in Patients with Type 2 Diabetes Mellitus
Frontiers in Pharmacology, 2017 Diabetic nephropathy is one of three major complications of diabetes mellitus, often leading to chronic renal failure requiring dialysis. Recently developed dipeptidyl peptidase-4 (DPP-4) inhibitors may exhibit renoprotective effects in addition to ...
Hiroki Esaki +16 more
doaj +1 more source
BMC Pharmacology and Toxicology, 2020 Background The purpose of this study was to evaluate and compare the effects on laboratory parameters among monotherapy with five DPP-4 inhibitors in patients with type 2 diabetes mellitus (DM). Methods We identified cohorts of new sitagliptin users (n =
Yayoi Nishida +5 more
doaj +1 more source
Cytoneme-mediated signaling essential for tumorigenesis. [PDF]
, 2019 Communication between neoplastic cells and cells of their microenvironment is critical to cancer progression. To investigate the role of cytoneme-mediated signaling as a mechanism for distributing growth factor signaling proteins between tumor and tumor ...
Fereres, Sol +3 more
core +1 more source
Impact of hypoglycemia on patients with type 2 diabetes mellitus and their quality of life, work productivity, and medication adherence. [PDF]
, 2014 BackgroundThe purpose of this study was to determine the characteristics of adults with type 2 diabetes mellitus (T2DM) that correlate with greater risk of hypoglycemia and determine the impact of hypoglycemia on health-related quality of life, work ...
Annunziata, Kathy +4 more
core +3 more sources
DPP-4 Inhibitor–Related Pancreatitis: Rare but Real! [PDF]
Diabetes Care, 2017 Following the U.S. Food and Drug Administration (FDA) Guidance issued in 2008 to demonstrate cardiovascular safety for the purpose of regulatory approval of new glucose-lowering agents for type 2 diabetes management, the number of placebo-controlled randomized clinical trials has increased exponentially.
DeVries, J. Hans, Rosenstock, Julio
openaire +2 more sources
Dose-Dependent Effect of Sitagliptin on Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus Receiving Insulin Treatment: A Post Hoc Analysis [PDF]
, 2017 IntroductionDipeptidyl peptidase-4 (DPP-4) inhibitors reduce blood glucose in a dose-dependent manner, but the dose-dependent effect relationship between DPP-4 inhibitors and atherosclerosis has not been investigated.MethodsPatients with type 2 diabetes ...
Gosho Masahiko +7 more
core +1 more source