Results 111 to 120 of about 40,250 (264)

Mechanistic Insight Into Ionizable Cationic Lipid‐Mediated Endosomal Escape via Transient Lipid Complexes

open access: yesSmall, EarlyView.
Coarse‐grained simulations show that the formation of transient anionic–cationic lipid pairs regulates the rate‐limiting step for the lamellar‐to‐hexagonal phase transition in mixtures of anionic and cationic lipids mimicking the endosomal membrane after fusion with lipid‐based nanoparticles, thus playing an important role in the endosomal escape of ...
David Noel Zimmer   +2 more
wiley   +1 more source

Estimating the seroprevalence of Mycobacterium bovis infection in a wild deer population in southwest England

open access: yesVeterinary Record, EarlyView.
Abstract Background In England, transmission of Mycobacterium bovis between cattle and certain species of free‐roaming, wild deer has been implicated in some endemic bovine tuberculosis (bTB) regions. However, there are still data and knowledge gaps regarding the role of deer in the epidemiology of this disease.
Rachel Jinks   +12 more
wiley   +1 more source

Dipeptidyl peptidase-4 inhibitors are associated with a lower risk of osteoarthritis in patients with type 2 diabetes. [PDF]

open access: yesTher Adv Musculoskelet Dis
Chen YH   +8 more
europepmc   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

open access: yesVIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang   +6 more
wiley   +1 more source

Sexual Safety Signals of Common Antidiabetic Drugs: Insights From FAERS Disproportionality Analysis

open access: yesAndrology, EarlyView.
ABSTRACT Background Erectile dysfunction is a prevalent and distressing complication of diabetes mellitus that markedly affects quality of life in male patients. Although the role of diabetes in erectile dysfunction is well‐established, potential drug‐induced sexual dysfunction associated with commonly prescribed antidiabetic medications remains ...
Shan Lin   +3 more
wiley   +1 more source

Mesopic microperimetry in Stargardt disease: Application and reliability

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose Mesopic microperimetry (mMP) is a promising functional endpoint in clinical trials for Stargardt disease type 1 (STGD1). This study evaluated the test–retest variability of mMP and influencing factors, which is essential for ensuring reliability in future STGD1 trials.
Sybren H. Kootstra   +12 more
wiley   +1 more source

Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity

open access: yesPeriodontology 2000, EarlyView., 2023
Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is ...
Crystal Marruganti   +2 more
wiley   +1 more source

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