Results 1 to 10 of about 28,624 (194)
Morphogen Transport in Epithelia [PDF]
Physical Review E, 2006 We present a general theoretical framework to discuss mechanisms of morphogen transport and gradient formation in a cell layer. Trafficking events on the cellular scale lead to transport on larger scales. We discuss in particular the case of transcytosis
B. Houchmandzadeh +8 more
core +7 more sources
Patterning principles of morphogen gradients
Open Biology, 2022 Metazoan embryos develop from a single cell into three-dimensional structured organisms while groups of genetically identical cells attain specialized identities.
Muhammed Simsek, Ertuğrul M Özbudak
exaly +3 more sources
Heterogeneity of Sonic Hedgehog response dynamics and fate specification in single neural progenitors [PDF]
eLifeDuring neural tube patterning, a gradient of Sonic hedgehog (Shh) signaling specifies ventral progenitor fates. The cellular response to Shh is processed through a genetic regulatory network (GRN) to specify distinct fate decisions.
Fengzhu Xiong +5 more
doaj +2 more sources
Robust formation of morphogen gradients
Physical Review Letters, 2004 We discuss the formation of graded morphogen profiles in a cell layer by nonlinear transport phenomena, important for patterning developing organisms. We focus on a process termed transcytosis, where morphogen transport results from binding of ligands to
A. Eldar +12 more
core +7 more sources
Temporal control of self‐organized pattern formation without morphogen gradients in bacteria
Molecular Systems Biology, 2013 Diverse mechanisms have been proposed to explain biological pattern formation. Regardless of their specific molecular interactions, the majority of these mechanisms require morphogen gradients as the spatial cue, which are either predefined or generated ...
Yangxiaolu Cao +2 more
exaly +2 more sources
Development, 2013 The graded distribution of morphogens underlies many of the tissue patterns that form during development. How morphogens disperse from a localized source and how gradients in the target tissue form has been under debate for decades. Recent imaging studies and biophysical measurements have provided evidence for various morphogen transport models ranging
Müller, Patrick +4 more
openaire +5 more sources
Patterning precision under non-linear morphogen decay and molecular noise
eLife, 2023 Morphogen gradients can instruct cells about their position in a patterned tissue. Non-linear morphogen decay has been suggested to increase gradient precision by reducing the sensitivity to variability in the morphogen source.
Jan Andreas Adelmann +2 more
doaj +1 more source
eLife, 2021 Spatial boundaries formed during animal development originate from the pre-patterning of tissues by signaling molecules, called morphogens. The accuracy of boundary location is limited by the fluctuations of morphogen concentration that thresholds the ...
Yonghyun Song, Changbong Hyeon
doaj +1 more source
Building a morphogen gradient without diffusion in a growing tissue. [PDF]
PLoS ONE, 2010 In many developmental systems, spatial pattern arises from morphogen gradients, which provide positional information for cells to determine their fate. Typically, diffusion is thought to be the mechanism responsible for building a morphogen gradient.
Rebecca H Chisholm +2 more
doaj +1 more source
Diffusion vs. direct transport in the precision of morphogen readout
eLife, 2020 Morphogen profiles allow cells to determine their position within a developing organism, but not all morphogen profiles form by the same mechanism. Here, we derive fundamental limits to the precision of morphogen concentration sensing for two canonical ...
Sean Fancher, Andrew Mugler
doaj +1 more source