Results 11 to 20 of about 28,651 (221)

Morphogen Gradient Formation [PDF]

Cold Spring Harbor Perspectives in Biology, 2009
How morphogen gradients are formed in target tissues is a key question for understanding the mechanisms of morphological patterning. Here, we review different mechanisms of morphogen gradient formation from theoretical and experimental points of view. First, a simple, comprehensive overview of the underlying biophysical principles of several mechanisms
Wartlick, O., Kicheva, A. and Gonzalez-Gaitan, M.   +4 more
openaire   +3 more sources

Pre-steady-state decoding of the Bicoid morphogen gradient. [PDF]

PLoS Biology, 2007
Morphogen gradients are established by the localized production and subsequent diffusion of signaling molecules. It is generally assumed that cell fates are induced only after morphogen profiles have reached their steady state.
Sven Bergmann, Oded Sandler, Hila Sberro, Sara Shnider, Eyal Schejter, Ben-Zion Shilo, Naama Barkai   +6 more
doaj   +1 more source

Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex

eLife, 2021
Morphogens function in concentration-dependent manners to instruct cell fate during tissue patterning. The cytoneme morphogen transport model posits that specialized filopodia extend between morphogen-sending and responding cells to ensure that ...
Eric T Hall, Miriam E Dillard, Daniel P Stewart, Yan Zhang, Ben Wagner, Rachel M Levine, Shondra M Pruett-Miller, April Sykes, Jamshid Temirov, Richard E Cheney, Motomi Mori, Camenzind G Robinson, Stacey K Ogden   +12 more
doaj   +1 more source

Wingless directly represses DPP morphogen expression via an armadillo/TCF/Brinker complex. [PDF]

PLoS ONE, 2007
BACKGROUND:Spatially restricted morphogen expression drives many patterning and regeneration processes, but how is the pattern of morphogen expression established and maintained?
Heidi Theisen, Adeela Syed, Baochi T Nguyen, Tamas Lukacsovich, Judith Purcell, Gyan Prakash Srivastava, David Iron, Karin Gaudenz, Qing Nie, Frederic Y M Wan, Marian L Waterman, J Lawrence Marsh   +11 more
doaj   +1 more source

Read-Out of Dynamic Morphogen Gradients on Growing Domains. [PDF]

PLoS ONE, 2015
Quantitative data from the Drosophila wing imaginal disc reveals that the amplitude of the Decapentaplegic (Dpp) morphogen gradient increases continuously.
Patrick Fried, Dagmar Iber
doaj   +1 more source

Quantitative analyses reveal extracellular dynamics of Wnt ligands in Xenopus embryos

eLife, 2021
The mechanism of intercellular transport of Wnt ligands is still a matter of debate. To better understand this issue, we examined the distribution and dynamics of Wnt8 in Xenopus embryos.
Yusuke Mii, Kenichi Nakazato, Chan-Gi Pack, Takafumi Ikeda, Yasushi Sako, Atsushi Mochizuki, Masanori Taira, Shinji Takada   +7 more
doaj   +1 more source

Improving the understanding of cytoneme-mediated morphogen gradients by in silico modeling.

PLoS Computational Biology, 2021
Morphogen gradients are crucial for the development of organisms. The biochemical properties of many morphogens prevent their extracellular free diffusion, indicating the need of an active mechanism for transport. The involvement of filopodial structures
Adrián Aguirre-Tamaral, Isabel Guerrero
doaj   +1 more source

Regulatory feedback on receptor and non-receptor synthesis for robust signaling. [PDF]

, 2020
Elaborate regulatory feedback processes are thought to make biological development robust, that is, resistant to changes induced by genetic or environmental perturbations. How this might be done is still not completely understood.
Lander, Arthur D, Nie, Qing, Sanchez-Tapia, Cynthia, Simonyan, Aghavni, Wan, Frederic YM   +4 more
core   +1 more source

Positive feedback regulation of frizzled-7 expression robustly shapes a steep Wnt gradient in Xenopus heart development, together with sFRP1 and heparan sulfate

eLife, 2022
Secreted molecules called morphogens govern tissue patterning in a concentration-dependent manner. However, it is still unclear how reproducible patterning can be achieved with diffusing molecules, especially when that patterning concerns differentiation
Takayoshi Yamamoto, Yuta Kambayashi, Yuta Otsuka, Boni A Afouda, Claudiu Giuraniuc, Tatsuo Michiue, Stefan Hoppler   +6 more
doaj   +1 more source

Local accumulation times for spatial difference in morphogen concentration

Results in Physics, 2017
During development of multicellular organisms, spatial patterns of cells and tissue organizations rely on the action of morphogens, which are signaling molecules and act as dose-dependent regulators of gene expression and cellular differentiation.
Xiaoqing Wen, Hongwei Yin
doaj   +1 more source