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Hormetic Electric Field Theory of Pattern Formation
The hormetic morphogen theory of curvature ( Fosslien 2009 ) proposes that hormetic morphogen concentration gradients modulate the synthesis of adenosine triphosphate (ATP) by cells along the gradients (field cells) and thus regulate their proliferation ...
Egil Fosslien
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Response to Nodal morphogen gradient is determined by the kinetics of target gene induction
Morphogen gradients expose cells to different signal concentrations and induce target genes with different ranges of expression. To determine how the Nodal morphogen gradient induces distinct gene expression patterns during zebrafish embryogenesis, we ...
Julien Dubrulle +6 more
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In vertebrates, the development of the central nervous system depends on the correct patterning of the neural tube along its anterior-posterior and dorsal-ventral axes in the early embryo as well as the underlying regulation of the cell differentiation ...
LIU Cong, XU Pengfei
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Analysis of a Model Biological Switch [PDF]
A model mechanism proposed by Murray [Phil. Traps. Roy. Soc. London B, 295 (1981), pp. 473–496] for generating wing patterns and eyespots on butterflies and moths is based on a morphogen (S) activated biological switch for a gene product (g).
Kath, W. L., Murray, J. D.
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Spatially Distributed Morphogen Production and Morphogen Gradient Formation
Partial diferential equations and auxiliary conditions governing the activities of the morphogen Dpp in Drosophila wing imaginal discs were formulated and analyzed as Systems B, R, and C in [7] [9] [10]. All had morphogens produced at the border of anterior and posterior chamber of the wing disc idealized as a point, line, or plane in a one-, two-, or ...
Arthur D. Lander +2 more
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Patterning of the Drosophila retina by the morphogenetic furrow
Pattern formation is the process by which cells within a homogeneous epithelial sheet acquire distinctive fates depending upon their relative spatial position to each other.
Jasmine Warren, Justin P. Kumar
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The interpretation of morphogen gradients is a pivotal concept in developmental biology, and several mechanisms have been proposed to explain how gene regulatory networks (GRNs) achieve concentration‐dependent responses.
James Cotterell, James Sharpe
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Well-posedness and asymptotic behavior of a multidimensional model of morphogen transport [PDF]
Morphogen transport is a biological process, occurring in the tissue of living organisms, which is a determining step in cell differentiation. We present rigorous analysis of a simple model of this process, which is a system coupling parabolic PDE with ...
A. Kicheva +9 more
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In vitro, morphogens such as transforming growth factor (TGF)-β can up-and down-regulate cell growth at low and high concentrations respectively, i.e. they behave like hormetic agents.
Egil Fosslien
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Decoding temporal interpretation of the morphogen Bicoid in the early Drosophila embryo
Morphogen gradients provide essential spatial information during development. Not only the local concentration but also duration of morphogen exposure is critical for correct cell fate decisions.
Anqi Huang +4 more
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