Results 51 to 60 of about 28,651 (221)

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Neuroepithelial organoid patterning is mediated by a neighborhood watch mechanism

Cell Reports, 2023
Summary: During epithelial tissue patterning, morphogens operate across multiple length scales to instruct cell identities. However, how cell fate changes are coordinated over these scales to establish spatial organization remains poorly understood. Here,
Abdel Rahman Abdel Fattah, Sergei Grebenyuk, Laura P.M.H. de Rooij, Idris Salmon, Adrian Ranga   +4 more
doaj   +1 more source

Parameter estimation and inference for stochastic reaction-diffusion systems: application to morphogenesis in D. melanogaster [PDF]

, 2010
Background: Reaction-diffusion systems are frequently used in systems biology to model developmental and signalling processes. In many applications, count numbers of the diffusing molecular species are very low, leading to the need to explicitly model ...
Dewar, M.A., Kadirkamanathan, V., Opper, M., Sanguinetti, G.   +3 more
core   +4 more sources

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Cellular compartmentalisation and receptor promiscuity as a strategy for accurate and robust inference of position during morphogenesis

eLife, 2023
Precise spatial patterning of cell fate during morphogenesis requires accurate inference of cellular position. In making such inferences from morphogen profiles, cells must contend with inherent stochasticity in morphogen production, transport, sensing ...
Krishnan S Iyer, Chaitra Prabhakara, Satyajit Mayor, Madan Rao   +3 more
doaj   +1 more source

Competition and boundary formation in heterogeneous media: Application to neuronal differentiation [PDF]

, 2014
We analyze an inhomogeneous system of coupled reaction-diffusion equations representing the dynamics of gene expression during differentiation of nerve cells. The outcome of this developmental phase is the formation of distinct functional areas separated
Perthame, Benoit, Quiñinao, Cristobal, Touboul, Jonathan   +2 more
core   +6 more sources

An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids

Advanced Materials Technologies, EarlyView.
This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto, Manuel Alejandro Vazquez Valle, Mitzi Pérez‐Calixto, Cindy Peto‐Gutiérrez, Iván Velasco, Genaro Vázquez‐Victorio, Itzel Escobedo‐Avila   +6 more
wiley   +1 more source

Robust tissue pattern formation by coupling morphogen signal and cell adhesion

EMBO Reports
Morphogens, locally produced signaling molecules, form a concentration gradient to guide tissue patterning. Tissue patterns emerge as a collaboration between morphogen diffusion and responsive cell behaviors, but the mechanisms through which diffusing ...
Kosuke Mizuno, Tsuyoshi Hirashima, Satoshi Toda   +2 more
doaj   +1 more source

Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action

eLife, 2017
Dpp, a member of the BMP family, is a morphogen that specifies positional information in Drosophila wing precursors. In this tissue, Dpp expressed along the anterior-posterior boundary forms a concentration gradient that controls the expression domains ...
Pablo Sanchez Bosch, Ruta Ziukaite, Cyrille Alexandre, Konrad Basler, Jean-Paul Vincent   +4 more
doaj   +1 more source

Modeling of Wnt-mediated tissue patterning in vertebrate embryogenesis.

PLoS Computational Biology, 2020
During embryogenesis, morphogens form a concentration gradient in responsive tissue, which is then translated into a spatial cellular pattern. The mechanisms by which morphogens spread through a tissue to establish such a morphogenetic field remain ...
Jakob Rosenbauer, Chengting Zhang, Benjamin Mattes, Ines Reinartz, Kyle Wedgwood, Simone Schindler, Claude Sinner, Steffen Scholpp, Alexander Schug   +8 more
doaj   +1 more source