Results 41 to 50 of about 28,651 (221)
Computational Evolutionary Embryogeny [PDF]
, 2010 Evolutionary and developmental processes are used to evolve the configurations of 3-D structures in silico to achieve desired performances. Natural systems utilize the combination of both evolution and development processes to produce remarkable ...
Antonsson, Erik K. +2 more
core +1 more source
Understanding how morphogens work [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2008 In this article, we describe the mechanisms by which morphogens in theXenopusembryo exert their long-range effects. Our results are consistent with the idea that signalling molecules such as activin and the nodal-related proteins traverse responding tissue not by transcytosis or by cytonemes but by movement through the extracellular space.
J C, Smith +3 more
openaire +2 more sources
Pentagone internalises glypicans to fine-tune multiple signalling pathways
eLife, 2016 Tight regulation of signalling activity is crucial for proper tissue patterning and growth. Here we investigate the function of Pentagone (Pent), a secreted protein that acts in a regulatory feedback during establishment and maintenance of BMP/Dpp ...
Mark Norman +4 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Morphogens determine cellular differentiation in many developing tissues in a concentration dependent manner. As a central model for gradient formation during animal development, Hedgehog (Hh) morphogens spread away from their source to direct growth and
Dominique Manikowski +8 more
doaj +1 more source
Numerical Methods for Two-Dimensional Stem Cell Tissue Growth. [PDF]
, 2013 Growth of developing and regenerative biological tissues of different cell types is usually driven by stem cells and their local environment. Here, we present a computational framework for continuum tissue growth models consisting of stem cells, cell ...
Nie, Qing, Ovadia, Jeremy
core +2 more sources
A unified design space of synthetic stripe-forming networks [PDF]
, 2014 Synthetic biology is a promising tool to study the function and properties of gene regulatory networks. Gene circuits with predefined behaviours have been successfully built and modelled, but largely on a case-by-case basis.
Cotterell, J +5 more
core +3 more sources
Cleavage activates Dispatched for Sonic Hedgehog ligand release
eLife, 2018 Hedgehog ligands activate an evolutionarily conserved signaling pathway that provides instructional cues during tissue morphogenesis, and when corrupted, contributes to developmental disorders and cancer.
Daniel P Stewart +7 more
doaj +1 more source
Noise control and utility: From regulatory network to spatial patterning [PDF]
, 2020 Stochasticity (or noise) at cellular and molecular levels has been observed extensively as a universal feature for living systems. However, how living systems deal with noise while performing desirable biological functions remains a major mystery ...
Nie, Qing +4 more
core +1 more source
eLife, 2017 The Bone Morphogenetic Protein (BMP) family reiteratively signals to direct disparate cellular fates throughout embryogenesis. In the developing dorsal spinal cord, multiple BMPs are required to specify sensory interneurons (INs).
Madeline G Andrews +5 more
doaj +1 more source
The biological frontier of pattern formation [PDF]
, 2018 Morphogenetic patterns are highly sophisticated dissipative structures. Are they governed by the same general mechanisms as chemical and hydrodynamic patterns? Turing's symmetry breaking and Wolpert's signalling provide alternative mechanisms.
Pismen, L. M.
core +2 more sources