Results 141 to 150 of about 172,883 (313)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
International Journal of Bio-Resource and Stress Management, 2018 Sustaining the healthy function and structure of natural ecosystems is a challenge, mainly due to the negative impacts of anthropogenic activities and climate change.
Valasia Iakovoglou, George N. Zaimes
doaj
Female images in Chinese films: passivity, seduction, and resistance through the male gaze
Cogent Arts & HumanitiesThe representation of women has been an integral part of China’s century-long cinematic history. Using Laura Mulvey’s gaze theory as the theoretical framework, this study reexamines the role types of women in Chinese cinema from the gendered perspective ...
Manyi Shi +2 more
doaj +1 more source
Jezik in slovstvo, 2006 The article deals with playwriting, as developed in France during the Second World War and the decade that followed, which was closely related to the philosophy of existentialism. After a brief overview of some definitions of existentialist drama, a new definition of the genre is made with the help of Szondi’s theses and the actant model by Anna ...
openaire +3 more sources
, 2015 Women’s history and women’s television, referring to television made with a discernibly female focus and targeted at a presumed female audience, can both be said to be marginalised within the wider context of their respective fields. The necessity of the
Mahoney, C, Mahoney, Cat
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
The BA program in Drama at the University of Washington
, 1987 Drama 401 colloquium; Recorded at the University of Washington, Seattle, on October 19 ...
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source