Results 61 to 70 of about 103,919 (263)

Diluted representation of Shoah and Education: the (tele)dramatic model in Jayme Monjardim’s Olga (2004)

Travessias, 2017
Piece of work on the problems of representation of Shoah (“Holocaust”) in film works, based on theoretical notions such as fictional resistance of the trauma, memory, and testimony.
Márcio Henrique Muraca
doaj  

DISCURSIVE REPRESENTATION OF CHARACTERS IN DRAMATIC TEXTS

Мова: кодифікація, компетенція, комунікація, 2021
Вступ. Проблема структурування драматичного тексту, функцій списку дійових осіб у композиційній та семантичній організації п’єси є важливою для інтерпретації твору драматургії. Проникнення в глибинні смислові та текстові зв’язки між аналізованим структурним компонентом та самим текстом уможливлює глибше розуміння естетичного задуму як читачів, так і ...
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Komično v umetnosti za otroke in mlade: kako 93 otroci in mladi dojemajo prvine humorja in se nanje odzivajo

Amfiteater
Komedija in elementi komičnega v umetnosti za otroke in mlade lahko segajo od šaljivega humorja do prefinjene duhovitosti, lahko so namenjeni zgolj zabavi, lahko pa služijo tudi kot način, kako mlajšemu občinstvu posredovati pomembna sporočila, in ga ...
Martina Peštaj, Benjamin Zajc
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Igrske akcije v novomedijskih umetniških delih

Amfiteater
Članek izhaja iz teorije video iger Alexandra R. Gallowaya. Gre za analizo medija, utemeljenega v akcijah, in njegovih specifik. Igrske akcije sistema igre izvajata upravljavec in stroj, odvijajo pa se tako v diegetskem kot nediegetskem prostoru igre. S
Narvika Bovcon
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Kje so meje?

Amfiteater
Prispevek si za osnovo jemlje razmerje med kulturo ukinjanja (angl. cancel culture) in z njo povezano politično korektnostjo ter komedijo in to razmerje natančneje artikulira ter ga vpne v družbenopolitični kontekst.
Maša Radi Buh, Nik Žnidaršič
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source